2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2001
Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women
Sofuoglu M, Babb D, Hatsukami D. Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women. Pharmacology Biochemistry And Behavior 2001, 69: 299-304. PMID: 11420098, DOI: 10.1016/s0091-3057(01)00527-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCross-Over StudiesDouble-Blind MethodFemaleFollicular PhaseHeart RateHumansProgesteroneSmokingConceptsEarly follicular phaseProgesterone treatmentFollicular phaseSmoking behaviorFemale smokersMenstrual cycleProgesterone levelsDose of progesteroneEffect of progesteroneSelf-administration periodMedication treatmentEndogenous estradiolExperimental sessionsExogenous progesteroneNicotine dependenceProgesteroneSubjective effectsSmokersTreatmentEstradiolSubjective responsesCigarettesSecond sessionSubjectsWomenIntravenous cocaine increases plasma epinephrine and norepinephrine in humans
Sofuoglu M, Nelson D, Babb D, Hatsukami D. Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. Pharmacology Biochemistry And Behavior 2001, 68: 455-459. PMID: 11325399, DOI: 10.1016/s0091-3057(01)00482-8.Peer-Reviewed Original ResearchConceptsNorepinephrine concentrationsPlasma epinephrineHeart rate changesBlood pressureCocaine injectionHuman studiesPeak plasma epinephrineSympathoadrenal system activationPlacebo-controlled studyDiastolic blood pressureSystolic blood pressureDose of cocaineMale cocaine usersPlasma norepinephrineEpinephrine levelsSympathoadrenal systemCocaine administrationIntravenous injectionSystem activationIntravenous cocaineEpinephrineConsecutive daysNorepinephrineCocaineCocaine users
2000
Carvedilol affects the physiological and behavioral response to smoked cocaine in humans
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Carvedilol affects the physiological and behavioral response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 60: 69-76. PMID: 10821991, DOI: 10.1016/s0376-8716(00)80009-5.Peer-Reviewed Original ResearchConceptsAcute treatmentPlacebo-controlled outpatient studyPhysiological effectsEffects of carvedilolDiastolic blood pressureCocaine-induced increasesNumber of cocaineCarvedilol treatmentBlood pressureOral carvedilolOutpatient studyNoradrenergic systemAdrenergic blockersCrack cocaine usersHeart rateCarvedilolBehavioral responsesCocaineCocaine usersCocaine deliveryTreatmentSubjective responsesTreatment conditionsResponseHumansEffects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Effects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine. Pharmacology Biochemistry And Behavior 2000, 65: 255-259. PMID: 10672977, DOI: 10.1016/s0091-3057(99)00201-4.Peer-Reviewed Original ResearchConceptsSystolic blood pressureLabetalol treatmentBlood pressureDose of labetalolEffects of labetalolSubjective responsesCocaine deliveryHeart rate increaseCocaine-induced increasesEffect of treatmentCrossover studyMedication treatmentCardiovascular responsesHeart rateAdrenergic receptorsLabetalolSmoked CocaineBehavioral effectsSubjective effectsCocaineDrug labetalolCocaine usersTreatmentDosesExperimental sessionsIndividual Differences in the Subjective Response to Smoked Cocaine in Humans
Sofuoglu M, Brown S, Dudish-Poulsen S, Hatsukami D. Individual Differences in the Subjective Response to Smoked Cocaine in Humans. The American Journal Of Drug And Alcohol Abuse 2000, 26: 591-602. PMID: 11097194, DOI: 10.1081/ada-100101897.Peer-Reviewed Original ResearchConceptsHeart rateBaseline Beck Depression Inventory scoresSubjective responsesBeck Depression Inventory scoresDiastolic blood pressureCocaine deliveryEffects of cocaineDepression Inventory scoresCocaine-dependent participantsBlood pressureMale sexCocaine use behaviorBody weightCocaine useSmoked CocaineAlcohol useInventory scoresCocaineCocaine usersPredictors of cardiovascular response to smoked cocaine in humans
Sofuoglu M, Nelson D, Dudish-Poulsen S, Lexau B, Pentel P, Hatsukami D. Predictors of cardiovascular response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 57: 239-245. PMID: 10661674, DOI: 10.1016/s0376-8716(99)00055-1.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdultArousalBlood PressureCocaine-Related DisordersCrack CocaineFemaleHeart RateHumansMaleConceptsCardiovascular responsesHeart rateHigher baseline blood pressureLong-term cocaine useCocaine useDiminished cardiovascular responseBaseline blood pressureBlood pressure changesAfrican American raceGreater cardiovascular responseCurrent cocaine useHigher body weightCardiovascular complicationsCurrent marijuana useBlood pressureMale sexCocaine administrationCurrent cocaineAmerican raceBody weightCocaineCocaine usersMarijuana usePredictorsPressure changes
1999
Sex and Menstrual Cycle Differences in the Subjective Effects From Smoked Cocaine in Humans
Sofuoglu M, Dudish-Poulsen S, Nelson D, Pentel P, Hatsukami D. Sex and Menstrual Cycle Differences in the Subjective Effects From Smoked Cocaine in Humans. Experimental And Clinical Psychopharmacology 1999, 7: 274-283. PMID: 10472516, DOI: 10.1037/1064-1297.7.3.274.Peer-Reviewed Original Research