2018
The Cholinergic System as a Treatment Target for Opioid Use Disorder
Jensen KP, DeVito EE, Yip S, Carroll KM, Sofuoglu M. The Cholinergic System as a Treatment Target for Opioid Use Disorder. CNS Drugs 2018, 32: 981-996. PMID: 30259415, PMCID: PMC6314885, DOI: 10.1007/s40263-018-0572-y.Peer-Reviewed Original ResearchConceptsCholinergic systemUse disordersTreatment targetsOpioid use disorder epidemicCentral nervous system functionTreatment of OUDEffects of acetylcholineOpioid use disorderTobacco use disorderNervous system functionOpioid medicationsDegrade acetylcholineCurrent treatmentOpioid overdosesPreclinical studiesMedicationsAcetylcholineCholinesterase inhibitorsAlzheimer's diseaseNew treatmentsAccidental deathGlobal healthTreatmentOUDDisease
2017
Inhalation of Alcohol Vapor: Measurement and Implications
MacLean RR, Valentine GW, Jatlow PI, Sofuoglu M. Inhalation of Alcohol Vapor: Measurement and Implications. Alcohol Clinical And Experimental Research 2017, 41: 238-250. PMID: 28054395, PMCID: PMC6143144, DOI: 10.1111/acer.13291.Peer-Reviewed Original ResearchConceptsAlcohol inhalationAlcohol consumptionAcute alcohol exposureElevated blood alcohol concentrationsRoute of administrationOral alcohol consumptionFirst-pass metabolismAlcohol use disorderPublic health concernMeasurement of biomarkersBlood alcohol concentrationRisk of addictionPharmacodynamic profileAlcohol exposureArterial circulationOccupational exposureMeasurable biomarkersPharmacological effectsUse disordersInhalationE-cigarettesHealth concernSubjective effectsRisk of problemsGoogle Scholar
2015
Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations
Arout CA, Edens E, Petrakis IL, Sofuoglu M. Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations. CNS Drugs 2015, 29: 465-486. PMID: 26142224, DOI: 10.1007/s40263-015-0255-x.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaClinical treatmentChronic painEfficacious treatment regimenTreatment of painOpioid-dependent individualsOpioid-related overdosesAminobutyric acid receptorsDeleterious profileProspective adjuvantOpioid prescriptionsSevere painOpioid analgesicsTreatment regimenNeuroimmune systemPainful stimuliSide effectsLong-term exposurePainAcid receptorsOpioidsClinical usePotential modulatorsHyperalgesiaParadoxical state
1993
7-Benzylidenenaltrexone (BNTX): A selective δ1 opioid receptor antagonist in the mouse spinal cord
Sofuoglu M, Portoghese P, Takemori A. 7-Benzylidenenaltrexone (BNTX): A selective δ1 opioid receptor antagonist in the mouse spinal cord. Life Sciences 1993, 52: 769-775. PMID: 8383271, DOI: 10.1016/0024-3205(93)90240-4.Peer-Reviewed Original ResearchConceptsAntinociceptive ED50 valueDELT IIED50 valuesDelta opioid receptor subtypesOpioid receptor subtypesDelta-opioid receptorsSubtype-selective agonistsAntinociceptive ED50Spinal sitesOpioid receptorsReceptor subtypesSelective agonistBNTXDPDPEMiceAdministrationHand administrationAntinociceptionRecent reportsDAMGONaltribenMorphineAgonistsAntagonistED50
1992
δ-Opioid receptor binding in mouse brain: Evidence for heterogeneous binding sites
Sofuoglu M, Portoghese P, Takemori A. δ-Opioid receptor binding in mouse brain: Evidence for heterogeneous binding sites. European Journal Of Pharmacology 1992, 216: 273-277. PMID: 1327813, DOI: 10.1016/0014-2999(92)90370-j.Peer-Reviewed Original ResearchConceptsMouse brainDelta-opioid receptor agonistDelta opioid receptor subtypesOpioid receptor agonistsBrains of miceOpioid receptor subtypesDelta-opioid receptorsΔ-opioid receptorsDelta opioidOpioid receptorsReceptor agonistReceptor subtypesBrainBinding sitesReceptorsOpioidsNaltribenDPDPEDSLETDADLEAgonistsSubtypesMiceEquipotentMaintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine
Sofuoglu M, Portoghese P, Takemori A. Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine. European Journal Of Pharmacology 1992, 210: 159-162. PMID: 1318206, DOI: 10.1016/0014-2999(92)90666-r.Peer-Reviewed Original ResearchConceptsMorphine injectionSelective kappa opioid antagonistED50 valuesKappa-opioid antagonistAcute morphine toleranceTail-flick assayDevelopment of toleranceKappa-opioid sitesAntinociceptive ED50 valueNon-pretreated controlsSupraspinal sitesOpioid toleranceMorphine administrationControl miceMorphine sulfateMorphine toleranceOpioid agonistsOpioid antagonistSpinal sitesSingle doseOpioid receptorsOpioid sitesMorphineMiceSelective blockage
1991
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
Sofuoglu M, Portoghese P, Takemori A. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 676-80. PMID: 1851833.Peer-Reviewed Original ResearchConceptsAntinociceptive ED50Antinociceptive actionMorphine sulfateAntinociceptive assaysDelta-opioid receptor agonistDelta opioid receptor subtypesDelta-opioid subtypesOpioid receptor agonistsOpioid receptor subtypesSingle large doseDelta-opioid agonistsPretreatment of animalsOpioid subtypesOpioid agonistsSpinal sitesDifferential antagonismReceptor agonistReceptor subtypesAntinociceptive activityD-Ala2Large doseDSLETDPDPENaltrindoleAntagonist activityCross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes
Sofuoglu M, Portoghese P, Takemori A. Cross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes. Life Sciences 1991, 49: pl153-pl156. PMID: 1658509, DOI: 10.1016/0024-3205(91)90397-t.Peer-Reviewed Original ResearchConceptsDelta opioid receptor subtypesOpioid receptor subtypesAntinociceptive effectReceptor subtypesAntinociceptive ED50 valueDelta-opioid receptor-selective peptideCross-tolerance studiesReceptor-selective peptideSpinal cordTolerance developmentFurther evidenceDPDPEED50 valuesMiceDADLEDAMGOSignificant increaseDSLETSame pretreatmentSubtypesAdministrationSelective peptidesCordFNA
1990
Naloxone produces protracted tolerance in mice treated with a single dose of morphine.
Sofuoglu M, Takemori A. Naloxone produces protracted tolerance in mice treated with a single dose of morphine. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 836-40. PMID: 2395115.Peer-Reviewed Original ResearchMaintenance of morphine dependence by naloxone in acutely dependent mice.
Sofuoglu M, Sato J, Takemori A. Maintenance of morphine dependence by naloxone in acutely dependent mice. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 841-6. PMID: 2395116.Peer-Reviewed Original ResearchConceptsMorphine sulfateNaloxone hydrochloridePriming doseED50 valuesSingle doseControl groupMorphine-pretreated miceOpioid antagonist naloxoneSigns of withdrawalDevelopment of dependenceMS injectionDependent miceAntagonist naloxoneMorphine dependenceMiceDoseFormer groupMS 24NaloxoneHrPretreatmentWithdrawalInjectionGroupDays