2021
Matched cohort study of germline BRCA mutation carriers with triple negative breast cancer in brightness
Metzger-Filho O, Collier K, Asad S, Ansell PJ, Watson M, Bae J, Cherian M, O’Shaughnessy J, Untch M, Rugo HS, Huober JB, Golshan M, Sikov WM, von Minckwitz G, Rastogi P, Li L, Cheng L, Maag D, Wolmark N, Denkert C, Symmans WF, Geyer CE, Loibl S, Stover DG. Matched cohort study of germline BRCA mutation carriers with triple negative breast cancer in brightness. Npj Breast Cancer 2021, 7: 142. PMID: 34764307, PMCID: PMC8586340, DOI: 10.1038/s41523-021-00349-y.Peer-Reviewed Original ResearchTriple-negative breast cancerNeoadjuvant chemotherapyCohort studyBreast cancerInstability scoreGenomic instability scoreGermline BRCA mutation carriersPathologic complete response rateAddition of carboplatinComplete response rateStandard neoadjuvant chemotherapyLymph node statusBRCA mutation carriersGermline BRCA1/2 mutationsNegative breast cancerOverall cohortNode statusTreatment armsHigher oddsMutation carriersBRCA1/2 mutationsResponse rateCarboplatinPARP inhibitorsCancer
2016
Breast conservation following neoadjuvant therapy for breast cancer in the modern era: Are we losing the opportunity?
Criscitiello C, Curigliano G, Burstein H, Wong S, Esposito A, Viale G, Giuliano M, Veronesi U, Santangelo M, Golshan M. Breast conservation following neoadjuvant therapy for breast cancer in the modern era: Are we losing the opportunity? European Journal Of Surgical Oncology 2016, 42: 1780-1786. PMID: 27825710, DOI: 10.1016/j.ejso.2016.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsAxillaBreast NeoplasmsClinical Decision-MakingFemaleGenes, BRCA1Genes, BRCA2Genetic Predisposition to DiseaseHereditary Breast and Ovarian Cancer SyndromeHumansLymph Node ExcisionMastectomyMastectomy, SegmentalMedical OveruseNeoadjuvant TherapyPatient PreferenceSurgical OncologyConceptsBreast conservationNeoadjuvant therapyBreast cancerSystemic therapyPathologic complete response rateComplete response rateBreast conservation ratesEffective systemic treatmentPatient-level variablesInvasive surgical approachNeoadjuvant trialsInoperable patientsSurgical overtreatmentSystemic treatmentSurgical approachSurgical benefitsOncology communityResponse ratePatientsTherapyCancerAggressive optionsMastectomySurgeonsConservation rate
2011
P2-08-02: Magnetic Resonance Imaging as a Predictor of Pathologic Response in Patients Treated with Neoadjuvant Systemic Treatment for Operable Breast Cancer (TBCRC 017).
De L, Cantor A, Mcguire K, Golshan M, Meric-Bernstam F, Horton J, Nanda R, Amos K, Forero A, Hudis C, Meszoely I, Hwang S. P2-08-02: Magnetic Resonance Imaging as a Predictor of Pathologic Response in Patients Treated with Neoadjuvant Systemic Treatment for Operable Breast Cancer (TBCRC 017). Cancer Research 2011, 71: p2-08-02-p2-08-02. DOI: 10.1158/0008-5472.sabcs11-p2-08-02.Peer-Reviewed Original ResearchRadiographic complete responseNeoadjuvant systemic therapyInvasive breast cancerSystemic therapyBreast cancerHR-/HER2Systemic treatmentTumor gradePathologic complete response rateTumor phenotypeBasis of estrogenComplete response rateOperable breast cancerMulticenter retrospective studyNeoadjuvant systemic treatmentMorbidity of surgeryHER2 receptor statusPrediction of pCRBreast cancer subtypesMagnetic resonance imagingHR-HER2IHC phenotypeChemotherapy regimenNeoadjuvant chemotherapyTN subtype