2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight managementRandomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomen
2022
Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants
Pichardo MS, Esserman D, Ferrucci LM, Molina Y, Chlebowski RT, Pan K, Garcia DO, Lane DS, Shadyab AH, Lopez‐Pentecost M, Luo J, Kato I, Springfield S, Rosal MC, Bea JW, Feliciano E, Qi L, Nassir R, Snetselaar L, Manson J, Bird C, Irwin ML. Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer 2022, 128: 3630-3640. PMID: 35996861, DOI: 10.1002/cncr.34428.Peer-Reviewed Original ResearchConceptsAmerican Cancer Society guidelinesObesity-related cancersWomen's Health InitiativeGuideline adherenceSociety guidelinesHealth initiativesPhysical activityLower riskEffect modificationCancer preventionObesity-related cancer incidenceObesity-related cancer riskWomen's Health Initiative participantsLatina womenPotential effect modificationPublic health interventionsNeighborhood socioeconomic statusCause deathCause mortalityLifestyle guidelinesPostmenopausal womenCancer incidenceLower incidenceACS guidelinesHigh adherence
2015
Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. Journal Of The National Cancer Institute 2015, 107: djv275. PMID: 26424778, PMCID: PMC4715249, DOI: 10.1093/jnci/djv275.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer-specific mortalityCancer-specific mortalityCause mortalityWeight gainBreast cancer diagnosisBreast cancerStage I-IIIC breast cancerSystematic reviewPrediagnosis body mass indexWomen age 18 yearsPostdiagnosis weight gainCancer diagnosisCause mortality ratesBreast cancer mortalityAge 18 yearsWeb of ScienceCohort studyRecurrence outcomesMass indexCancer mortalityClinical trialsHigh riskMortality rateBody weight
2014
Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML. Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative. Gynecologic Oncology 2014, 133: 4-10. PMID: 24680584, PMCID: PMC4064800, DOI: 10.1016/j.ygyno.2014.01.033.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeBody mass indexVigorous-intensity physical activityOvarian cancerPhysical activityHealth initiativesLower riskCause mortalityMass indexSelf-reported physical activityOvarian cancer mortalityModifiable lifestyle factorsProportional hazards regressionPrimary ovarian cancerOvarian cancer diagnosisPostmenopausal womenBaseline visitHazards regressionLifestyle factorsCancer mortalityMortality endpointsSurvival rateMortalityCancerCancer diagnosis
2011
Physical Activity and Survival in Postmenopausal Women with Breast Cancer: Results from the Women's Health Initiative
Irwin ML, McTiernan A, Manson JE, Thomson CA, Sternfeld B, Stefanick ML, Wactawski-Wende J, Craft L, Lane D, Martin LW, Chlebowski R. Physical Activity and Survival in Postmenopausal Women with Breast Cancer: Results from the Women's Health Initiative. Cancer Prevention Research 2011, 4: 522-529. PMID: 21464032, PMCID: PMC3123895, DOI: 10.1158/1940-6207.capr-10-0295.Peer-Reviewed Original ResearchConceptsCause mortalityPostmenopausal womenPhysical activityBreast cancerMore MetHealth initiativesLower breast cancer mortalityBreast cancer-specific mortalityWomen's Health Initiative studyActive breast cancer survivorsCancer-specific mortalityInvasive breast cancerLow physical activityBreast cancer survivorsMultivariable adjusted analysesWomen's Health InitiativeBreast cancer mortalityAdjusted analysisCancer survivorsCancer mortalityInactive womenInitiative studyMortalityCancerDiagnosis