2022
Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function
Martinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function. Cell Reports Medicine 2022, 3: 100621. PMID: 35584631, PMCID: PMC9133468, DOI: 10.1016/j.xcrm.2022.100621.Peer-Reviewed Original ResearchConceptsMonocytes/macrophagesDendritic cellsMetastatic melanomaMelanoma cellsMetastatic cutaneous melanomaRegulation of toleranceSpecific transcriptional signatureTranscriptional profilingGene setsLaser capture microdissectionCell-based therapiesTranscriptional signatureCutaneous melanomaDC functionPatient outcomesMetastatic cancerTumor nestsTCGA cohortImmune functionCandidate biomarkersCD14Stromal macrophagesTumor siteTherapeutic opportunitiesAntigen capture
2007
Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling
Hystad ME, Myklebust JH, Bø TH, Sivertsen EA, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt LM, Smeland EB. Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling. The Journal Of Immunology 2007, 179: 3662-3671. PMID: 17785802, DOI: 10.4049/jimmunol.179.6.3662.Peer-Reviewed Original ResearchConceptsHuman B cell developmentB cell developmentGene expression profilingCell developmentTranscription factorsExpression profilingHemopoietic stem cellsLineage-associated transcription factorsInteresting expression patternsStem cellsMyeloid-associated genesExpression of genesAdult bone marrowFunctional assignmentImmature B cellsKey genesCDNA microarrayGene setsExpression patternsVDJ recombinationUnknown roleB-lymphoid cellsGenesB cellsRNA amplification