2024
Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series
Sujijantarat N, Koo A, Elsamadicy A, Antonios J, Renedo D, Haynes J, Fathima B, Theriault B, Chavez M, Amllay A, Nowicki K, Kanzler M, Jiang J, Shekar A, Hebert R, DiLuna M, Matouk C. Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series. Neurosurgery Open 2024, 5: e00113. DOI: 10.1227/neuprac.0000000000000113.Peer-Reviewed Original ResearchIdiopathic intracranial hypertensionIntracranial hypertensionTreatment of idiopathic intracranial hypertensionManagement of idiopathic intracranial hypertensionMedical records of patientsAssessment of long-term outcomesHigh-pressure headachesMedian operative timeDifficult-to-manage patientsLow-pressure headacheCerebrospinal fluid shuntsElectronic medical records of patientsRecords of patientsFollow-up visitLong-term outcomesLumbar shuntDifficult-to-manage casesIntraoperative complicationsShunt revisionImprove headacheCase seriesEarly outcomesSurgical techniqueNeurosurgical managementOperative timeHigh inpatient-opioid consumption predicts extended length of hospital stay in patients undergoing spinal fusion for adolescent idiopathic scoliosis
Sandhu M, Craft S, Reeves B, Sayeed S, Hengartner A, Tuason D, DiLuna M, Elsamadicy A. High inpatient-opioid consumption predicts extended length of hospital stay in patients undergoing spinal fusion for adolescent idiopathic scoliosis. Spine Deformity 2024, 1-11. PMID: 39320702, DOI: 10.1007/s43390-024-00960-6.Peer-Reviewed Original ResearchLength of hospital stayPosterior spinal fusionAdolescent idiopathic scoliosisProportion of patientsAdverse eventsCost of admissionHospital stayIdiopathic scoliosisSpinal fusionMethodsA retrospective cohort studyLogistic multivariate regression analysisIncreased 30-day readmission ratePost-operative adverse eventsExtended length of hospital stayHospital length of stayReadmission ratesPost-operative analgesiaRetrospective cohort studyPremier Healthcare DatabaseHigh cohortPerioperative adverse eventsMultivariate regression analysisIncreased cost of admissionLength of staySpine surgeryRegional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis
Sayeed S, Theriault B, Hengartner A, Serrato P, Sadeghzadeh S, Belkasim S, Ahsan N, Elsamadicy E, DiLuna M, Elsamadicy A. Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis. Child's Nervous System 2024, 1-10. PMID: 38955900, DOI: 10.1007/s00381-024-06514-5.Peer-Reviewed Original ResearchNational Inpatient SampleIntraoperative variablesLong-term neurodevelopmental outcomesLow gestational ageMultivariate logistic regression analysisPermanent CSF shuntNational database analysisLow birth weightPercentage of patientsRetrospective cohort studyAssociated with decreased oddsImpact of insurance statusAssociated with reduced oddsMedian total costAssociated with mortalityLogistic regression analysisBackgroundIntraventricular hemorrhageNeonatal IVHGestational ageIntraventricular hemorrhageNeurodevelopmental outcomesCSF diversionCSF shuntingCost of admissionBirth weightInsurance Disparities in Patient Outcomes and Healthcare Resource Utilization Following Neonatal Intraventricular Hemorrhage
Sayeed S, Theriault B, Hengartner A, Ahsan N, Sadeghzadeh S, Elsamadicy E, DiLuna M, Elsamadicy A. Insurance Disparities in Patient Outcomes and Healthcare Resource Utilization Following Neonatal Intraventricular Hemorrhage. World Neurosurgery 2024, 189: e46-e54. PMID: 38815926, DOI: 10.1016/j.wneu.2024.05.136.Peer-Reviewed Original ResearchIntraventricular hemorrhagePI patientsInsurance statusAssociated with surgical delayDiagnosis of intraventricular hemorrhageMultivariate logistic regression analysisNeonatal intraventricular hemorrhageAssociated with increased healthcare utilizationNational Inpatient Sample databaseRetrospective cohort studyImpact of insurance statusTime to referralAssociated with increased oddsInpatient Sample databaseAssociation of insurance statusLogistic regression analysisLength of stayMyelomeningocele repairSurgical delayCost of admissionAdverse eventsPrivate insuranceCohort studyMedicaid patientsPI cohortSociodemographic Disparities and Postoperative Outcomes Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database
Hengartner A, Serrato P, Sayeed S, Sadeghzadeh S, Prassinos A, Alperovich M, DiLuna M, Elsamadicy A. Sociodemographic Disparities and Postoperative Outcomes Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database. Journal Of Craniofacial Surgery 2024, 35: 1310-1314. PMID: 38752737, DOI: 10.1097/scs.0000000000010303.Peer-Reviewed Original ResearchNon-Hispanic blacksNon-Hispanic whitesLength of stayCranial vault repairAdverse eventsNational Surgical Quality Improvement Program-Pediatric databaseAmerican College of Surgeons National Surgical Quality Improvement Program Pediatric databaseMultivariate logistic regression analysisNSQIP-Pediatric databaseAge of presentationNon-Hispanic Black patientsNon-Hispanic white patientsIncreased complication rateHospital length of stayExtended length of stayPostoperative clinical outcomesEquitable health careRetrospective cohort studyCranial vault remodelingCurrent Procedural Terminology codesPostoperative adverse eventsCranial vault reconstructionProcedural Terminology codesLogistic regression analysisNon-white patientsIsolated unilateral alar ligamentous injury: illustrative cases
Reeves B, Valcarce-Aspegren M, Robert S, Elsamadicy A, Tucker A, Storm P, DiLuna M, Kundishora A. Isolated unilateral alar ligamentous injury: illustrative cases. Journal Of Neurosurgery Case Lessons 2024, 7: case23664. PMID: 38560931, PMCID: PMC10988229, DOI: 10.3171/case23664.Peer-Reviewed Original ResearchMagnetic resonance imagingCervical collarAdequate first-line treatmentAlar ligament injuryUpper cervical traumaMagnetic resonance imaging evidenceHard cervical collarRigid cervical collarFirst-line treatmentResolution of symptomsRigid external immobilizationNeck painNeck tendernessCervical traumaHalo fixationPediatric patientsDefinitive diagnosisNonsurgical managementCervical radiographsModerate courseFollow-upLigament strainExternal immobilizationOdontoid processPatientsReduced racial disparities among newborns with intraventricular hemorrhage
Sayeed S, Reeves B, Theriault B, Hengartner A, Ahsan N, Sadeghzadeh S, Elsamadicy E, DiLuna M, Elsamadicy A. Reduced racial disparities among newborns with intraventricular hemorrhage. Child's Nervous System 2024, 40: 2051-2059. PMID: 38526575, DOI: 10.1007/s00381-024-06369-w.Peer-Reviewed Original ResearchLength of stayIntroductionIntraventricular hemorrhageAdverse eventsMultivariate logistic regression analysisRate of adverse eventsPermanent neurological dysfunctionProlonged length of stayNational Inpatient Sample databaseRates of NECInpatient Sample databaseLogistic regression analysisIntraventricular hemorrhageAA patientsImpact of raceCost of admissionIndependent predictorsRate of mortalityPatient characteristicsMultivariate analysisPercentage of AAWhite patientsNeurological dysfunctionNewbornsPatient genderPatientsImpact of a quality improvement initiative and monthly multidisciplinary meetings on outcomes after posterior spinal fusion for adolescent idiopathic scoliosis
Hengartner A, Elsamadicy A, Jonnalagadda A, Craft S, Sherman J, Reeves B, Fernandez T, Hobbs J, Koo A, DiLuna M, Tuason D. Impact of a quality improvement initiative and monthly multidisciplinary meetings on outcomes after posterior spinal fusion for adolescent idiopathic scoliosis. Spine Deformity 2024, 12: 1043-1051. PMID: 38493442, DOI: 10.1007/s43390-024-00859-2.Peer-Reviewed Original ResearchPosterior spinal instrumented fusionPre-QI cohortAdolescent idiopathic scoliosisMultidisciplinary team meetingsProportion of patientsLength of stayPre-QITeam meetingsPost-QIPostoperative complicationsIdiopathic scoliosisQuality improvementQuality improvement initiativesPostoperative ambulationBenefits of enhanced recoveryMethodsThe medical recordsPain control protocolIntraoperative drain placementPosterior spinal fusionSpinal instrumented fusionQI implementationImprovement initiativesPatient careAmbulation statusDrain placement
2023
Influence of affective disorders on outcomes after suboccipital decompression for adult Chiari I malformation
Sherman J, Sayeed S, Craft S, Reeves B, Hengartner A, Fernandez T, Koo A, DiLuna M, Elsamadicy A. Influence of affective disorders on outcomes after suboccipital decompression for adult Chiari I malformation. Clinical Neurology And Neurosurgery 2023, 236: 108104. PMID: 38171050, DOI: 10.1016/j.clineuro.2023.108104.Peer-Reviewed Original ResearchHealthcare resource utilizationNon-routine dischargeLength of stayChiari I malformationAD cohortSuboccipital decompressionAffective disordersAdverse eventsPatient demographicsPostoperative eventsAdmission costsExtended LOSMean LOSNational Inpatient Sample databaseMultivariate logistic regression analysisAdult Chiari I malformationIncidence of syringomyeliaPerioperative adverse eventsChronic pulmonary diseaseICD-10-CM codesGreater proportionLogistic regression analysisComorbid affective disordersAdult patientsIndependent predictorsAssociated Risk Factors for Extended Operative Time Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database
Serrato P, Hengartner A, Sayeed S, Prassinos A, Alperovich M, DiLuna M, Elsamadicy A. Associated Risk Factors for Extended Operative Time Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database. Journal Of Craniofacial Surgery 2023, 35: 427-431. PMID: 38078913, DOI: 10.1097/scs.0000000000009920.Peer-Reviewed Original ResearchExtended operative timeCranial vault remodelingRetrospective cohort studyAdverse eventsCohort studyIndependent predictorsPediatric patientsOperative timeRisk factorsVault remodelingNational Surgical Quality Improvement Program-PediatricHealth care resource utilizationPostoperative surgical site infectionSurgeons National Surgical Quality Improvement Program-PediatricMultivariate logistic regression analysisDiseases 9/10 codesNSQIP-Pediatric databasePostoperative adverse eventsHigher American SocietySurgical site infectionAssociated risk factorsSurgical adverse eventsLength of stayLogistic regression analysisNon-Hispanic whites
2022
Spinal Cord Stimulation as an approach to treating Parsonage Turner Syndrome
Seaton C, Bushey D, Haddad D, Diluna M, Chow R. Spinal Cord Stimulation as an approach to treating Parsonage Turner Syndrome. Interventional Pain Medicine 2022, 1: 100111. PMID: 39238526, PMCID: PMC11373047, DOI: 10.1016/j.inpm.2022.100111.Peer-Reviewed Original ResearchBiallelic inactivation of PBRM1 as a molecular driver in a rare pineoblastoma case: illustrative case
Antonios JP, Yalcin K, Darbinyan A, Koo A, Hong CS, DiLuna M, Erson-Omay Z. Biallelic inactivation of PBRM1 as a molecular driver in a rare pineoblastoma case: illustrative case. Journal Of Neurosurgery Case Lessons 2022, 3: case2213. PMID: 36303510, PMCID: PMC9379698, DOI: 10.3171/case2213.Peer-Reviewed Original ResearchMolecular driversPineal parenchymal tumorsRenal cell carcinomaRare tumor typeParenchymal tumorsCell carcinomaBladder carcinomaPapillary featuresPineoblastomaTumor subtypesTumor typesConsensus groupBiallelic lossGenomic profilingCancer typesMolecular level alterationsLevel alterationsGenomic driversBiallelic inactivationCarcinomaDriver eventsTumor suppressorGenetic phenotypesPathway changesMultiomics studies134 Racial Disparities in Healthcare Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries: Is it Black and White?
Elsamadicy A, Sandhu M, Freedman I, Koo A, Hengartner A, Reeves B, Havlik J, Sarkozy M, Kundishora A, Tuason D, DiLuna M. 134 Racial Disparities in Healthcare Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries: Is it Black and White? Neurosurgery 2022, 68: 39-39. DOI: 10.1227/neu.0000000000001880_134.Peer-Reviewed Original ResearchHealthcare resource utilizationAfrican American patientsMultivariate regression analysisAfrican American cohortHospital complicationsHospital LOSComplication ratePediatric patientsSpinal traumaRacial disparitiesGreater prevalenceLogistic multivariate regression analysisLength of ICUOverall complication rateThoracic spine injuriesAfrican American raceDiagnosis coding systemRegression analysisThoracic spinal injuryPaucity of dataAfrican American/BlackUnited States healthcare systemICU LOSHospital stayInjury presentations193 Arachnoid Cysts as Genetically-encoded Harbingers of Neurodevelopmental Pathology
Kundishora A, Kiziltug E, Allington G, Allocco A, Smith H, Ocken J, Moreno-De-Luca A, DiLuna M, Jin S, Kahle K. 193 Arachnoid Cysts as Genetically-encoded Harbingers of Neurodevelopmental Pathology. Neurosurgery 2022, 68: 58-58. DOI: 10.1227/neu.0000000000001880_193.Peer-Reviewed Original ResearchGene expressionGene setsScRNAseq datasetsWhole-exome sequencingSingle-cell RNA sequencing dataExome-wide significanceCell type relationshipsMultiple epigenetic regulatorsRNA sequencing dataMulti-omics approachExome sequencingChromatin remodelingEpigenetic regulationMRNA processingPhenomic analysisEpigenetic regulatorsPhenomics techniquesIntegrative genomicsSequencing dataSignificant enrichmentGenesFirst insightPhenotypic clustersNovo variantsNovel associations
2020
Impact of Pulmonary Risk Factors on Postoperative Outcomes Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis
Elsamadicy A, Freedman I, Koo A, David W, Havlik J, Reeves B, Sarkozy M, Kundishora A, Sciubba D, Kahle K, DiLuna M. Impact of Pulmonary Risk Factors on Postoperative Outcomes Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_591.Peer-Reviewed Original ResearchRelationship Between Preoperative Anemia and Perioperaive Outcomes Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis
Elsamadicy A, Freedman I, Koo A, David W, Havlik J, Reeves B, Sarkozy M, Kundishora A, Sciubba D, Kahle K, DiLuna M. Relationship Between Preoperative Anemia and Perioperaive Outcomes Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_595.Peer-Reviewed Original ResearchIntegrative Genomics Implicates Genetic Disruption of Prenatal Neurogenesis in Congenital Hydrocephalus
Panchagnula S, Jin S, Dong W, Kundishora A, Moreno-De-Luca A, Furey C, Allocco A, Walker R, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zen X, Sierant M, Knight J, Sullivan W, Phan D, DeSpenza T, Reeves B, Karimy J, Marlier A, Castaldi C, Tikhonova I, Li B, Peña; H, Broach J, Kabachelor E, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake A, Goto J, Mangano F, Johnston J, Butler W, Warf B, Smith E, Schiff S, Limbrick D, Heuer G, Jackson E, Iskandar B, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan C, Apuzzo M, DiLuna M, Hoffman E, Sestan N, Ment L, Alper S, Bilguvar K, Geschwind D, Günel M, Lifton R, Kahle K. Integrative Genomics Implicates Genetic Disruption of Prenatal Neurogenesis in Congenital Hydrocephalus. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_572.Peer-Reviewed Original ResearchA passive, biocompatible microfluidic flow sensor to assess flows in a cerebral spinal fluid shunt
Garrett A, Soler G, Diluna M, Grant R, Zaveri H, Hoshino K. A passive, biocompatible microfluidic flow sensor to assess flows in a cerebral spinal fluid shunt. Sensors And Actuators A Physical 2020, 312: 112110. DOI: 10.1016/j.sna.2020.112110.Peer-Reviewed Original ResearchFlow rateMicrofluidic flow sensorNovel microfluidic sensorBiocompatible polydimethylsiloxaneMicrofluidic sensorFlow sensorSensor stabilityImplanted electronicsSensor systemOptical detection systemSensor positionsBiocompatible materialsSensorsCantileverPolydimethylsiloxaneOutput lightOptical systemCerebral spinal fluidFlowMaterialsFluidLight spotElectronicsManufacturingDetection system
2019
Exome Sequencing Defines the Molecular Pathogenesis of Vein of Galen Malformation
Kundishora A, Zeng X, Duran D, Allocco A, Choi J, Jin S, Conine S, Nelson-Williams C, Gaillard J, Furey C, Timberlake A, Mansuri M, Sorscher M, Klein J, Lu Q, Montejo J, Vera A, Karimy J, Panchagnula S, Youngblood M, DiLuna M, Matouk C, Mane S, Alper S, Ducruet A, Zabramski J, Aagaard-Kienitz B, Rodesch G, Smith E, Orbach D, Berenstein A, Bilguvar K, Gunel M, Lifton R, Kahle K. Exome Sequencing Defines the Molecular Pathogenesis of Vein of Galen Malformation. Neurosurgery 2019, 66: 310-341. DOI: 10.1093/neuros/nyz310_341.Peer-Reviewed Original ResearchHGG-01. ACQUISITION OF A HYPERMUTATOR PHENOTYPE UNDERLYING DISTANT SPINAL INTRAMEDULLARY SPREAD IN HISTONE-MUTATED DIFFUSE MIDLINE GLIOMA
Hong C, Kundishora A, Fomchenko E, Huttner A, Erson-Omay Z, Marks A, Diluna M, Kahle K. HGG-01. ACQUISITION OF A HYPERMUTATOR PHENOTYPE UNDERLYING DISTANT SPINAL INTRAMEDULLARY SPREAD IN HISTONE-MUTATED DIFFUSE MIDLINE GLIOMA. Neuro-Oncology 2019, 21: ii86-ii86. PMCID: PMC6477387, DOI: 10.1093/neuonc/noz036.095.Peer-Reviewed Original ResearchIntramedullary spinal metastasesDiffuse midline gliomaMidline gliomaWhole-exome sequencingSpinal metastasesKey oncogenic driver mutationsSomatic mutationsExome sequencingLower extremity weaknessDistant metastatic spreadHigh-grade astrocytic tumorsGenetic alterationsOncogenic driver mutationsSpinal metastatic lesionsProton beam radiationThirteen-year-old maleSpinal intramedullaryExtremity weaknessDistant spreadMetastatic lesionsLumbar tumorsPineal lesionsPoor prognosisTumor spreadPineal tumors