2020
JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCL
Yumeen S, Mirza FN, Lewis JM, King ALO, Kim SR, Carlson KR, Umlauf SR, Surovtseva YV, Foss FM, Girardi M. JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCL. Blood Advances 2020, 4: 2213-2226. PMID: 32437546, PMCID: PMC7252559, DOI: 10.1182/bloodadvances.2020001756.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaJAK inhibitionCTCL cellsMalignant cutaneous T-cell lymphomasAdvanced cutaneous T-cell lymphomaTreatment of CTCLAvailable systemic treatment optionsSkin-homing T lymphocytesSystemic treatment optionsT-cell lymphomaCTCL cell linesHistone deacetylase inhibitionGeneralized cytotoxic effectExpression of Bcl2Advanced diseaseSuch patientsPeripheral bloodTreatment optionsJAK/STAT pathwayT lymphocytesPreclinical assessmentTherapeutic targetStrong potentiationExtrinsic apoptosis pathwayDeacetylase inhibition
2008
FDG-PET/CT in the Evaluation of Cutaneous T-Cell Lymphoma
Kuo PH, McClennan BL, Carlson K, Wilson LD, Edelson RL, Heald PW, Girardi M. FDG-PET/CT in the Evaluation of Cutaneous T-Cell Lymphoma. Molecular Imaging And Biology 2008, 10: 74-81. PMID: 18196347, DOI: 10.1007/s11307-007-0127-y.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaPET/CTT-cell lymphomaFDG uptakeD-glucose positron emission tomography/FDG PET/CTPositron emission tomography/PET/CT scansComprehensive case seriesTomography (CT) of patientsMonitoring of responseMalignant adenopathyActive diseaseAdvanced diseaseCutaneous examinationVisceral diseaseVisceral involvementLymph nodesCase seriesCutaneous lesionsPhysical examinationThicker tumorsTomography/Physical examIndividual patients