2014
Mechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells
Lewis JM, Bürgler CD, Fraser JA, Liao H, Golubets K, Kucher CL, Zhao PY, Filler RB, Tigelaar RE, Girardi M. Mechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells. Journal Of Investigative Dermatology 2014, 135: 1405-1414. PMID: 25233073, PMCID: PMC4364923, DOI: 10.1038/jid.2014.411.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaLC-deficient miceLangerhans cellsPresence of LCCutaneous squamous cell carcinomaEpidermal Langerhans cellsMyeloid-derived cellsEnzyme CYP1B1Infundibular keratinocytesDendritic cellsCell carcinomaInvasive malignancyCutaneous carcinogenesisCarcinogenesis roleTobacco smokeLC precursorsMalignant transformationTumor progressionMetastatic potentialTumor susceptibilityMiceChemical carcinogenesisCarcinogenesisNeoplastic transformationLC expression
2012
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma
Modi BG, Neustadter J, Binda E, Lewis J, Filler RB, Roberts SJ, Kwong BY, Reddy S, Overton JD, Galan A, Tigelaar R, Cai L, Fu P, Shlomchik M, Kaplan DH, Hayday A, Girardi M. Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma. Science 2012, 335: 104-108. PMID: 22223807, PMCID: PMC3753811, DOI: 10.1126/science.1211600.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsAryl Hydrocarbon HydroxylasesCarcinogensCarcinoma, Squamous CellCell Transformation, NeoplasticCells, CulturedCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA DamageGenes, rasHumansKeratinocytesLangerhans CellsMiceMice, TransgenicSkin NeoplasmsT-LymphocytesConceptsLangerhans cellsDendritic cellsDMBA-induced DNA damageCutaneous chemical carcinogenesisEpidermal dendritic cellsLC-deficient miceT cell immunitySquamous cell carcinomaChemical carcinogenesisDMBA-transHras mutationsCell immunityCell carcinomaImmune cellsDNA damageTumor resistanceDMBAPrior incubationHuman keratinocytesCarcinogenesisUnderlying mechanismMicePotent carcinogenSkinPAH metabolism
2009
Molecular Analysis of Tumor-Promoting CD8+ T Cells in Two-Stage Cutaneous Chemical Carcinogenesis
Kwong BY, Roberts SJ, Silberzahn T, Filler RB, Neustadter JH, Galan A, Reddy S, Lin WM, Ellis PD, Langford CF, Hayday AC, Girardi M. Molecular Analysis of Tumor-Promoting CD8+ T Cells in Two-Stage Cutaneous Chemical Carcinogenesis. Journal Of Investigative Dermatology 2009, 130: 1726-1736. PMID: 19924136, PMCID: PMC2920801, DOI: 10.1038/jid.2009.362.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAmphiregulinAnimalsCD8-Positive T-LymphocytesCell DifferentiationDisease Models, AnimalEGF Family of ProteinsForkhead Transcription FactorsGene Expression ProfilingGlycoproteinsHepatitis A Virus Cellular Receptor 2Intercellular Signaling Peptides and ProteinsInterleukin-10Interleukin-17MiceMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, VirusSkin NeoplasmsConceptsTumor-infiltrating lymphocytesT cellsCutaneous carcinogenesisIL-17-producing T cellsT-proCutaneous chemical carcinogenesisTricolor flow cytometryContribution of inflammationCytolytic T cellsTumor-bearing miceEpithelial growth factorMechanism of actionT helperCancer immunotherapyUseful biomarkerMalignant progressionFlow cytometryClear associationGrowth factorReduced cytotoxicChemical carcinogenesisCarcinogenesisPro phenotypeWhole genome expression analysisTime-course analysis
2007
Cutaneous two-stage chemical carcinogenesis.
Filler RB, Roberts SJ, Girardi M. Cutaneous two-stage chemical carcinogenesis. Cold Spring Harbor Protocols 2007, 2007: pdb.prot4837. PMID: 21357170, DOI: 10.1101/pdb.prot4837.Peer-Reviewed Original ResearchTwo-stage chemical carcinogenesisChemical carcinogenesisCutaneous malignanciesCutaneous tumorsCutaneous carcinogenesisBenign papillomasImmunological pathwaysPrecursor lesionsTopical administrationPro-inflammatory phorbol estersCancer developmentMouse skinTumor susceptibilityCarcinogenesisTumorsProgressionPhorbol esterLate eventSkinInductionMalignancyPapillomasLesionsMiceAdministrationCharacterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis
Roberts SJ, Ng BY, Filler RB, Lewis J, Glusac EJ, Hayday AC, Tigelaar RE, Girardi M. Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 6770-6775. PMID: 17412837, PMCID: PMC1871860, DOI: 10.1073/pnas.0604982104.Peer-Reviewed Original ResearchConceptsT cell deficiencyT cellsCell deficiencyPRO cellsCell-deficient miceTumor-infiltrating lymphocytesAnti-tumor responseT cell populationsInflammation-associated carcinogenesisT cell receptorImmunotherapeutic strategiesRegulatory cellsCancer immunosurveillanceCell reconstitutionEpidemiologic linkCutaneous carcinogenesisTumor incidenceCyclooxygenase-2Activated populationCell receptorNovel populationCell populationsChemical carcinogenesisCarcinogenesisLymphocytes