2013
Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling
Durazzo TS, Tigelaar RE, Filler R, Hayday A, Girardi M, Edelson RL. Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling. Transfusion And Apheresis Science 2013, 50: 370-378. PMID: 24360371, PMCID: PMC4167725, DOI: 10.1016/j.transci.2013.11.008.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaExtracorporeal photochemotherapyDendritic cellsDendritic cell maturationT-cell lymphomaInduction of monocytesEvidence of inductionPost-capillary venulesDC maturationCell lymphomaClinical actionsCell maturationPlatelet signalingMonocytesPhotochemotherapyReceptor-ligand interactionsNovel mechanismInductionPhysiological inductionMaturationPrevious studiesLymphomaTherapyVenules
2010
Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy
Berger C, Hoffmann K, Vasquez JG, Mane S, Lewis J, Filler R, Lin A, Zhao H, Durazzo T, Baird A, Lin W, Foss F, Christensen I, Girardi M, Tigelaar R, Edelson R. Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy. Blood 2010, 116: 4838-4847. PMID: 20720185, PMCID: PMC3321745, DOI: 10.1182/blood-2009-11-256040.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationCell DifferentiationCell SeparationDendritic CellsFlow CytometryGene ExpressionGraft vs Host DiseaseHumansImmunophenotypingIn Situ HybridizationLymphoma, T-Cell, CutaneousMonocytesOligonucleotide Array Sequence AnalysisPhotopheresisReverse Transcriptase Polymerase Chain ReactionConceptsCutaneous T-cell lymphomaCostimulatory surface moleculesHuman dendritic cellsT-cell lymphomaDC differentiation pathwayAutoreactive disordersTherapeutic DCsDifferentiation pathwayHost diseaseDendritic cellsExtracorporeal photochemotherapyDistinctive molecular signaturesClinical efficacyOrgan rejectionCancer immunotherapyFunctional DCsEndogenous antigensNormal monocytesNormal subjectsClinical successCell differentiation pathwayLevel of expressionDisease statesMonocytesEnhanced expression
2003
Selective immmunotherapy through extracorporeal photochemotherapy: yesterday, today, and tomorrow
Girardi M, Knobler R, Edelson R. Selective immmunotherapy through extracorporeal photochemotherapy: yesterday, today, and tomorrow. Hematology/Oncology Clinics Of North America 2003, 17: 1391-1403. PMID: 14710891, DOI: 10.1016/s0889-8588(03)00106-0.Peer-Reviewed Original ResearchConceptsLow side effect profileSide effect profilePotential novel strategyMechanism of actionImmunosuppressive medicationsExtracorporeal photochemotherapyEffect profileTransplant rejectionTreatment of cancerClinical recordsRole of ECPClinical studiesT cellsTreatment considerationsModern therapeuticsTreatmentNovel strategyGVHDMedicationsAutoimmunityCTCLMalignancyECPTherapyCancer
2002
Transimmunization and the evolution of extracorporeal photochemotherapy
Girardi M, Schechner J, Glusac E, Berger C, Edelson R. Transimmunization and the evolution of extracorporeal photochemotherapy. Transfusion And Apheresis Science 2002, 26: 181-190. PMID: 12126204, DOI: 10.1016/s1473-0502(02)00011-3.Peer-Reviewed Original ResearchConceptsDC/T cell interactionExtracorporeal photopheresisT cell responsesT cell interactionsT cell receptorPotent T cell responsesSpecific T cell responsesCutaneous T-cell lymphomaT cell-mediated diseaseDendritic cell therapyT cell reactionsT-cell lymphomaOrgan transplant rejectionT-cell malignanciesExtracorporeal photochemotherapySelective immunotherapyTransplant rejectionImmune effectsImmune responsePatients' leukocytesCell malignanciesEffective antigenCell therapyFirst FDACancer cells