2016
Induction of anti-tumor CD8 T cell responses by experimental ECP-induced human dendritic antigen presenting cells
Kibbi N, Sobolev O, Girardi M, Edelson RL. Induction of anti-tumor CD8 T cell responses by experimental ECP-induced human dendritic antigen presenting cells. Transfusion And Apheresis Science 2016, 55: 146-152. PMID: 27317354, DOI: 10.1016/j.transci.2016.06.001.Peer-Reviewed Original ResearchConceptsCD8 T cell responsesCutaneous T-cell lymphomaT cell responsesCell responsesCD8 T cell populationsMonocyte-derived DCsAnti-tumor immunityT cell populationsT-cell lymphomaAntigen presenting cellsClass I major histocompatibilityCentral mechanistic roleMelanoma-associated proteinImmunotherapeutic managementHost diseaseAllograft rejectionPresenting cellsDendritic antigenImmunologic reactionsCell lymphomaMalignant cloneMajor histocompatibilityPathogenic clonesCell populationsAntigen
2014
Integrin‐driven monocyte to dendritic cell conversion in modified extracorporeal photochemotherapy
Gonzalez AL, Berger CL, Remington J, Girardi M, Tigelaar RE, Edelson RL. Integrin‐driven monocyte to dendritic cell conversion in modified extracorporeal photochemotherapy. Clinical & Experimental Immunology 2014, 175: 449-457. PMID: 24188174, PMCID: PMC3927905, DOI: 10.1111/cei.12231.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaDC differentiationHuman leucocyte antigen DDendritic antigen-presenting cellsPlasma proteinsAntigen-presenting cellsT-cell lymphomaECP efficacyHost diseaseClinical efficacySafety profileSelective immunizationCell lymphomaAntigen DCell treatmentMonocytesPhenotypic expressionEfficacyNovel mechanismECPDifferentiationCD83ImmunosuppressionCD86Fibronectin
2010
Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy
Berger C, Hoffmann K, Vasquez JG, Mane S, Lewis J, Filler R, Lin A, Zhao H, Durazzo T, Baird A, Lin W, Foss F, Christensen I, Girardi M, Tigelaar R, Edelson R. Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy. Blood 2010, 116: 4838-4847. PMID: 20720185, PMCID: PMC3321745, DOI: 10.1182/blood-2009-11-256040.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationCell DifferentiationCell SeparationDendritic CellsFlow CytometryGene ExpressionGraft vs Host DiseaseHumansImmunophenotypingIn Situ HybridizationLymphoma, T-Cell, CutaneousMonocytesOligonucleotide Array Sequence AnalysisPhotopheresisReverse Transcriptase Polymerase Chain ReactionConceptsCutaneous T-cell lymphomaCostimulatory surface moleculesHuman dendritic cellsT-cell lymphomaDC differentiation pathwayAutoreactive disordersTherapeutic DCsDifferentiation pathwayHost diseaseDendritic cellsExtracorporeal photochemotherapyDistinctive molecular signaturesClinical efficacyOrgan rejectionCancer immunotherapyFunctional DCsEndogenous antigensNormal monocytesNormal subjectsClinical successCell differentiation pathwayLevel of expressionDisease statesMonocytesEnhanced expression
2002
Transimmunization, a novel approach for tumor immunotherapy
Berger CL, Hanlon D, Kanada D, Girardi M, Edelson RL. Transimmunization, a novel approach for tumor immunotherapy. Transfusion And Apheresis Science 2002, 26: 205-216. PMID: 12126207, DOI: 10.1016/s1473-0502(02)00014-9.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaImmune responseTumor antigensPotent antigen presenting cellsAnti-tumor immune responseExtracorporeal photopheresis (ECP) treatmentDendritic cell immunotherapyT-cell lymphomaAntigen presenting cellsPeripheral blood monocytesApoptotic tumor cellsApoptotic CTCL cellsPhotopheresis treatmentRejection episodesHost diseaseOvernight incubation periodTumor epitopesImmature DCsCell immunotherapyTumor immunotherapyAutoimmune diseasesDC differentiationInflammatory cytokinesPresenting cellsCell lymphoma
2001
Extracorporeal Photochemoimmunotherapy in Cutaneous T Cell Lymphomas
KNOBLER R, GIRARDI M. Extracorporeal Photochemoimmunotherapy in Cutaneous T Cell Lymphomas. Annals Of The New York Academy Of Sciences 2001, 941: 123-138. PMID: 11594566, DOI: 10.1111/j.1749-6632.2001.tb03716.x.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT cell clonesAutoreactive T cell clonesT-cell lymphomaCell clonesCell lymphomaDisease-causing T cellsPathogenic T cell clonesT cell-mediated disordersClass I Major Histocompatibility Complex PresentationClonotypic T cell receptorCell-mediated disordersTumor-specific antigensMajor histocompatibility complex presentationT cell receptorTypes of cancerUnique antigenic determinantsECP efficacyHost diseaseAllograft rejectionConversion of monocytesSelective immunotherapyClinical trialsFunctional DCsDendritic antigen
2000
CUTANEOUS T-CELL LYMPHOMA AND CUTANEOUS GRAFT-VERSUS-HOST DISEASE Two Indications for Photopheresis in Dermatology
Girardi M, Heald PW. CUTANEOUS T-CELL LYMPHOMA AND CUTANEOUS GRAFT-VERSUS-HOST DISEASE Two Indications for Photopheresis in Dermatology. Dermatologic Clinics 2000, 18: 417-423. PMID: 10943537, DOI: 10.1016/s0733-8635(05)70190-x.Peer-Reviewed Original Research
1999
Extracorporeal photochemotherapy in human and murine graft-versus-host disease
Girardi M, McNiff J, Heald P. Extracorporeal photochemotherapy in human and murine graft-versus-host disease. Journal Of Dermatological Science 1999, 19: 106-113. PMID: 10098701, DOI: 10.1016/s0923-1811(98)00066-8.Peer-Reviewed Original Research
1995
Specific Suppression of Lupus-Like Graft-Versus-Host Disease Using Extracorporeal Photochemical Attenuation of Effector Lymphocytes
Girardi M, Herreid P, Tigelaar R. Specific Suppression of Lupus-Like Graft-Versus-Host Disease Using Extracorporeal Photochemical Attenuation of Effector Lymphocytes. Journal Of Investigative Dermatology 1995, 104: 177-182. PMID: 7829872, DOI: 10.1111/1523-1747.ep12612741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAscitesAutoimmune DiseasesDisease Models, AnimalFemaleGlomerulonephritisGraft vs Host DiseaseGraft vs Host ReactionImmunotherapy, AdoptiveKidneyLupus Erythematosus, SystemicMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred DBAPUVA TherapyT-LymphocytesVaccinationConceptsSystemic lupus erythematosus-like diseaseB6D2F1 recipientsDisease initiationD2 cellsAntinuclear antibody titerLupus-like graftProgression of graftVersus Host DiseaseSystemic lupus erythematosusC3H/HeJ xDBA/2 splenocytesHost diseaseLupus erythematosusEffector lymphocytesClinical manifestationsClinical parametersHistologic evidenceAntibody titersKidney diseaseAscites formationB6D2F1 miceInterleukin-2T cellsC57BL/6 xComplex antigens