2014
Mechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells
Lewis JM, Bürgler CD, Fraser JA, Liao H, Golubets K, Kucher CL, Zhao PY, Filler RB, Tigelaar RE, Girardi M. Mechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells. Journal Of Investigative Dermatology 2014, 135: 1405-1414. PMID: 25233073, PMCID: PMC4364923, DOI: 10.1038/jid.2014.411.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaLC-deficient miceLangerhans cellsPresence of LCCutaneous squamous cell carcinomaEpidermal Langerhans cellsMyeloid-derived cellsEnzyme CYP1B1Infundibular keratinocytesDendritic cellsCell carcinomaInvasive malignancyCutaneous carcinogenesisCarcinogenesis roleTobacco smokeLC precursorsMalignant transformationTumor progressionMetastatic potentialTumor susceptibilityMiceChemical carcinogenesisCarcinogenesisNeoplastic transformationLC expression
2012
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma
Modi BG, Neustadter J, Binda E, Lewis J, Filler RB, Roberts SJ, Kwong BY, Reddy S, Overton JD, Galan A, Tigelaar R, Cai L, Fu P, Shlomchik M, Kaplan DH, Hayday A, Girardi M. Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma. Science 2012, 335: 104-108. PMID: 22223807, PMCID: PMC3753811, DOI: 10.1126/science.1211600.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsAryl Hydrocarbon HydroxylasesCarcinogensCarcinoma, Squamous CellCell Transformation, NeoplasticCells, CulturedCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA DamageGenes, rasHumansKeratinocytesLangerhans CellsMiceMice, TransgenicSkin NeoplasmsT-LymphocytesConceptsLangerhans cellsDendritic cellsDMBA-induced DNA damageCutaneous chemical carcinogenesisEpidermal dendritic cellsLC-deficient miceT cell immunitySquamous cell carcinomaChemical carcinogenesisDMBA-transHras mutationsCell immunityCell carcinomaImmune cellsDNA damageTumor resistanceDMBAPrior incubationHuman keratinocytesCarcinogenesisUnderlying mechanismMicePotent carcinogenSkinPAH metabolism
2007
Cutaneous two-stage chemical carcinogenesis.
Filler RB, Roberts SJ, Girardi M. Cutaneous two-stage chemical carcinogenesis. Cold Spring Harbor Protocols 2007, 2007: pdb.prot4837. PMID: 21357170, DOI: 10.1101/pdb.prot4837.Peer-Reviewed Original ResearchTwo-stage chemical carcinogenesisChemical carcinogenesisCutaneous malignanciesCutaneous tumorsCutaneous carcinogenesisBenign papillomasImmunological pathwaysPrecursor lesionsTopical administrationPro-inflammatory phorbol estersCancer developmentMouse skinTumor susceptibilityCarcinogenesisTumorsProgressionPhorbol esterLate eventSkinInductionMalignancyPapillomasLesionsMiceAdministration
2006
Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant
Lewis JM, Girardi M, Roberts SJ, D Barbee S, Hayday AC, Tigelaar RE. Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant. Nature Immunology 2006, 7: 843-850. PMID: 16829962, DOI: 10.1038/ni1363.Peer-Reviewed Original ResearchConceptsT cellsIntraepithelial lymphocytesT cell receptorMouse dendritic epidermal T-cellsOligoclonal T-cell receptorsDendritic epidermal T cellsEpidermal T cellsT cell repertoireT cell progenitorsCutaneous pathologyCell repertoireThymic stromaStromal determinantsLymphocyte repertoireCell receptorLymphocytesCell progenitorsHeritable defectsCellsIntraepithelialAgonistsMicePathologyPhysiological useStroma
2002
Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation
Girardi M, Lewis J, Glusac E, Filler RB, Geng L, Hayday AC, Tigelaar RE. Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation. Journal Of Experimental Medicine 2002, 195: 855-867. PMID: 11927630, PMCID: PMC2193718, DOI: 10.1084/jem.20012000.Peer-Reviewed Original ResearchConceptsT cell receptorEpidermal T cellsT cellsIrritant dermatitisGammadelta T-cell receptorT cell-mediated inflammationCell-mediated inflammationSystemic inflammatory reactionIrritant contact dermatitis reactionsΓδ T cellsGammadelta T cellsContact dermatitis reactionsCutaneous inflammationIEL subsetsChronic dermatitisFunctional impairmentInflammatory reactionDermatitis reactionsEpithelial interfaceCell subpopulationsCell receptorMiceMouse strainsDermatitisSingle autosomal recessive gene
2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesis