2024
Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy
Ren J, Liao X, Lewis J, Chang J, Qu R, Carlson K, Foss F, Girardi M. Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy. Nature Communications 2024, 15: 519. PMID: 38225288, PMCID: PMC10789731, DOI: 10.1038/s41467-024-44786-2.Peer-Reviewed Original ResearchConceptsAntibody-dependent cellular cytotoxicityDonor T cellsT cellsAdeno-associated virus transductionHealthy donor T cellsHost-versus-graft reactivityEnhanced antibody-dependent cellular cytotoxicityCAR-T cellsGraft-versus-hostT cell killingT-cell malignanciesMalignant T cellsNormal T-cellT cell receptorOff-target toxicityPre-existing immunoreactivityCAR-TDisease relapseCellular cytotoxicityVirus transductionCurrent treatmentPersister killingFc engineeringB2MIn vivo
2011
Characterization of the DNA Copy-Number Genome in the Blood of Cutaneous T-Cell Lymphoma Patients
Lin WM, Lewis JM, Filler RB, Modi BG, Carlson KR, Reddy S, Thornberg A, Saksena G, Umlauf S, Oberholzer PA, Karpova M, Getz G, Mane S, Garraway LA, Dummer R, Berger CL, Edelson RL, Girardi M. Characterization of the DNA Copy-Number Genome in the Blood of Cutaneous T-Cell Lymphoma Patients. Journal Of Investigative Dermatology 2011, 132: 188-197. PMID: 21881587, PMCID: PMC3841973, DOI: 10.1038/jid.2011.254.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaBlood involvementLeukemic cutaneous T-cell lymphomaCutaneous T-cell lymphoma patientsT-cell lymphoma patientsNormal CD4 countPeripheral blood isolatesT-cell lymphomaCTCL cell linesPotential future therapeutic developmentsT-cell malignanciesFuture therapeutic developmentSignificant copy number alterationsCD4 countSpectrum of stagesCTCL patientsSézary syndromeLymph nodesLymphoma patientsHodgkin's lymphomaPeripheral bloodBlood isolatesCutaneous patchCTCL samplesPatients
2002
Transimmunization and the evolution of extracorporeal photochemotherapy
Girardi M, Schechner J, Glusac E, Berger C, Edelson R. Transimmunization and the evolution of extracorporeal photochemotherapy. Transfusion And Apheresis Science 2002, 26: 181-190. PMID: 12126204, DOI: 10.1016/s1473-0502(02)00011-3.Peer-Reviewed Original ResearchConceptsDC/T cell interactionExtracorporeal photopheresisT cell responsesT cell interactionsT cell receptorPotent T cell responsesSpecific T cell responsesCutaneous T-cell lymphomaT cell-mediated diseaseDendritic cell therapyT cell reactionsT-cell lymphomaOrgan transplant rejectionT-cell malignanciesExtracorporeal photochemotherapySelective immunotherapyTransplant rejectionImmune effectsImmune responsePatients' leukocytesCell malignanciesEffective antigenCell therapyFirst FDACancer cells
2001
The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma
BERGER C, LONGLEY J, HANLON D, GIRARDI M, EDELSON R. The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma. Annals Of The New York Academy Of Sciences 2001, 941: 106-122. PMID: 11594564, DOI: 10.1111/j.1749-6632.2001.tb03715.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, NeoplasmCancer VaccinesCD8-Positive T-LymphocytesCell LineCells, CulturedHumansHybridomasImmunoglobulin IdiotypesLymphocyte ActivationLymphoma, T-Cell, CutaneousMiceNeoplasm TransplantationPeptidesReceptors, Antigen, T-CellSkin NeoplasmsSurvival RateT-Lymphocytes, CytotoxicTransfectionConceptsCutaneous T-cell lymphomaT-cell lymphomaT cell receptorClonotypic T cell receptorCell lymphomaAutologous CD8 T cellsCD8 T cell linesCell receptorBeta chainCD8 T cell recognitionImmunogenic tumor peptidesCD8 T cellsCell surface TCR expressionClass I MHC moleculesSource of tumorsT cell recognitionT-cell malignanciesTCR beta chainI MHC moleculesT cell linesTCR epitopesTumor epitopesDendritic cellsSurface TCR expressionCancer vaccines