2014
IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis
Liu J, Harberts E, Tammaro A, Girardi N, Filler RB, Fishelevich R, Temann A, Licona-Limón P, Girardi M, Flavell RA, Gaspari AA. IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis. Journal Of Investigative Dermatology 2014, 134: 1903-1911. PMID: 24487305, PMCID: PMC4303591, DOI: 10.1038/jid.2014.61.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisIL-9 productionIL-9IL-4Contact dermatitisAllergen-specific Th1 responsesHuman allergic contact dermatitisPositive patch test sitesPeripheral blood mononuclear cellsCytokine IL-9Non-atopic patientsContact hypersensitivity modelIFN-γ productionIL-4 secretionBlood mononuclear cellsNickel-allergic patientsLymphocyte immune responseSkin biopsy specimensWild-type micePatch test sitesTh9 lymphocytesAllergic asthmaIL-17ATh1 responseCytokines IFN
2011
High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade
Kießling M, Oberholzer PA, Mondal C, Karpova MB, Zipser MC, Lin WM, Girardi M, MacConaill LE, Kehoe SM, Hatton C, French LE, Garraway LA, Polier G, Süss D, Klemke CD, Krammer PH, Gülow K, Dummer R. High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade. Blood 2011, 117: 2433-2440. PMID: 21209378, PMCID: PMC3952811, DOI: 10.1182/blood-2010-09-305128.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyHigh-Throughput Screening AssaysHumansLymphoma, T-Cell, CutaneousMitogen-Activated Protein Kinase KinasesMutationMycosis FungoidesNeoplasm StagingProtein Kinase InhibitorsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Raf KinasesRas ProteinsSezary SyndromeSignal TransductionConceptsCutaneous T-cell lymphomaStage IV patientsHUT78 cellsIV patientsPleomorphic cutaneous T-cell lymphomaHigh-throughput mutation profilingMEK inhibitorsCTCL cell line Hut78T-cell lymphomaRAS/RAF/MEKCTCL cell linesOncogenic mutationsCommon oncogenic mutationsCTCL patientsOverall survivalSézary syndromeMycosis fungoidesBiopsy specimensPatients profitPreclinical resultsMEK inhibitor U0126NRAS mutationsLymphoid cellsCTCL samplesRAS mutations