2022
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis
Mai Y, Ouyang Y, Yu M, Qin Y, Girardi M, Saltzman WM, Cocco E, Zhao C, Yu L, Jia Y, Xiao L, Dou L, Deng W, Liu Y, Xie J, Deng Y. Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis. Journal Of Controlled Release 2022, 349: 354-366. PMID: 35817278, DOI: 10.1016/j.jconrel.2022.07.006.Peer-Reviewed Original ResearchConceptsHealthy skinPsoriasis treatmentTopical formulationsPsoriatic skinCurrent psoriasis treatmentsFirst-line treatmentSingle-dose cureLocal drug concentrationModerate psoriasisLesional skinSingle doseDermal atrophyTherapeutic levelsTherapeutic efficacyCorticosteroidsDrug concentrationsPsoriasisBNPBasal cellsSkin retentionSkinLesionsBioadhesive nanoparticlesTreatmentStratum corneum
2021
Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles
Hu JK, Suh HW, Qureshi M, Lewis JM, Yaqoob S, Moscato ZM, Griff S, Lee AK, Yin ES, Saltzman WM, Girardi M. Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2020575118. PMID: 33526595, PMCID: PMC7896333, DOI: 10.1073/pnas.2020575118.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaNonsurgical treatmentSkin cancerTumor cell surfaceIntratumoral drug deliveryHistologic cureCutaneous malignanciesSurgical excisionTherapeutic standardTumor burdenTumor immunotherapyTumor injectionCommon malignancyCell carcinomaSCC tumorsNonsurgical alternativeTherapeutic efficacyD postinjectionNanoparticle drug delivery systemsChemotherapeutic agentsSuperficial tumorsTumorsLocal deliveryEnhanced survivalPercutaneous delivery
2015
A sunblock based on bioadhesive nanoparticles
Deng Y, Ediriwickrema A, Yang F, Lewis J, Girardi M, Saltzman WM. A sunblock based on bioadhesive nanoparticles. Nature Materials 2015, 14: 1278-1285. PMID: 26413985, PMCID: PMC4654636, DOI: 10.1038/nmat4422.Peer-Reviewed Original ResearchConceptsBioadhesive nanoparticlesCommercial sunscreen formulationsInorganic ultraviolet (UV) filtersUV filtersCellular exposureCutaneous phototoxicityMurine modelFollicular penetrationHealth concernNanoparticlesUV filter concentrationsTowel dryingPadimate OUV protectionSunblockSunscreen formulationsStratum corneumUltraviolet filtersExposureFilter