2024
Perioperative Care in Cardiac Surgery: A Joint Consensus Statement by the Enhanced Recovery After Surgery (ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS)
Grant M, Crisafi C, Alvarez A, Arora R, Brindle M, Chatterjee S, Ender J, Fletcher N, Gregory A, Gunaydin S, Jahangiri M, Ljungqvist O, Lobdell K, Morton V, Reddy V, Salenger R, Sander M, Zarbock A, Engelman D. Perioperative Care in Cardiac Surgery: A Joint Consensus Statement by the Enhanced Recovery After Surgery (ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS). The Annals Of Thoracic Surgery 2024, 117: 669-689. PMID: 38284956, DOI: 10.1016/j.athoracsur.2023.12.006.Peer-Reviewed Original ResearchSociety of Thoracic SurgeonsCardiac surgeryImproved postoperative clinical outcomesConsensus statementPostoperative clinical outcomesEnhanced recoveryMultidisciplinary expert panelJoint consensus statementSurgical insultThoracic surgeonsAdult patientsClinical outcomesPerioperative interventionsSurgeryERAS principlesPerioperative careRelevant interventionsCardiac SocietyClinical practiceSpecialty operationsExpert panelPromote recoveryCardiacInternational SocietyProgram elements
2023
Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer
Stockhammer P, Grant M, Wurtz A, Foggetti G, Expósito F, Gu J, Zhao H, Choi J, Chung S, Li F, Walther Z, Dietz J, Duffield E, Gettinger S, Politi K, Goldberg S. Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer. Journal Of Thoracic Oncology 2023, 19: 240-251. PMID: 37806385, PMCID: PMC11364167, DOI: 10.1016/j.jtho.2023.10.001.Peer-Reviewed Original ResearchProgression-free survivalEGFR-mutant NSCLCTP53 mutationsOverall survivalClinical outcomesEGFR-TKIInferior outcomesWorse outcomesYale cohortMetastatic EGFR-mutant NSCLCShorter progression-free survivalEGFR-mutant lung cancerTyrosine kinase inhibitor therapyFirst-line TKIYale Cancer CenterSecond-line therapyInferior clinical outcomesSubset of patientsKinase inhibitor therapyAdditional therapeutic interventionsAggressive disease phenotypeCo-occurring alterationsTumor suppressor gene alterationsTumor genomic profilingMultiple tumor suppressor genesEfficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations
Grant M, Aredo J, Starrett J, Stockhammer P, van Rosenburgh I, Wurtz A, Piper-Valillo A, Piotrowska Z, Falcon C, Yu H, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li F, Neal J, Lemmon M, Walther Z, Politi K, Goldberg S. Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations. Clinical Cancer Research 2023, 29: of1-of8. PMID: 36913537, PMCID: PMC10493186, DOI: 10.1158/1078-0432.ccr-22-3497.Peer-Reviewed Original ResearchConceptsProgression-free survivalNon-small cell lung cancerInferior progression-free survivalMulticenter retrospective cohortEfficacy of osimertinibMulti-institutional cohortCell lung cancerExon 19 deletion mutationUncommon EGFRRetrospective cohortClinical outcomesClinical efficacyLung cancerOsimertinib efficacyEGFR mutationsPreclinical modelsEx19delPatientsAACR Genie databaseLater linesOsimertinibMutant cohortFirst lineCohortEfficacy
2020
Risk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Lorente J, Ramirez-Rodriguez J, Grant M. Risk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery. Surgery Today 2020, 51: 537-544. PMID: 32785846, DOI: 10.1007/s00595-020-02107-2.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge FactorsAgedAged, 80 and overColonCreatinineDigestive System Surgical ProceduresEnhanced Recovery After SurgeryFemaleHumansMaleMalnutritionMiddle AgedMulticenter Studies as TopicNutritional StatusPostoperative ComplicationsProspective StudiesRectumRisk FactorsROC CurveSerum AlbuminConceptsPostoperative acute kidney injuryAcute kidney injuryColorectal surgeryRisk factorsKidney injuryLow preoperative albumin levelRecovery pathwaysPerioperative patient outcomesPreoperative albumin levelEnhanced recovery pathwayIndependent risk factorProspective cohort studyPoor clinical outcomeDirect healthcare costsOpen surgical approachMalnourished patientsCohort studyAlbumin levelsASA IIILarge multicenterPreoperative interventionClinical outcomesMultivariable analysisOverall incidenceModifiable factors
2019
On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study
Cho B, Jung Y, DeMario V, Lau E, Podlasek S, Grant M, Gehrie E, Frank S. On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study. Transfusion 2019, 59: 2678-2684. PMID: 31121073, DOI: 10.1111/trf.15355.Peer-Reviewed Original ResearchConceptsUrgent reversalLabel useMortality rateFour-factor prothrombin complex concentrateAcute major bleedingVitamin K antagonistsProthrombin complex concentrate useProthrombin complex concentrateOff-label useCoagulation factor deficienciesHospital mortalityMajor bleedingK antagonistsPatient characteristicsClinical outcomesBlood utilizationExpensive treatment optionsLabel indicationsSingle institutionTreatment optionsComplex concentrateObservational studyFactor deficiencyInvasive proceduresOff label
2018
Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials
Zorrilla-Vaca A, Healy R, Grant M, Joshi B, Rivera-Lara L, Brown C, Mirski M. Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials. Journal Canadien D'anesthésie 2018, 65: 529-542. PMID: 29427259, DOI: 10.1007/s12630-018-1065-7.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionIntensive care unitIntraoperative cerebral oximetryCerebral oximetryPostoperative deliriumIncidence of POCDProspective clinical trialsOverall hospital LOSPredictors of outcomeGoogle Scholar databasesHospital LOSPurposeAlthough evidenceHospital lengthPerioperative outcomesPostoperative outcomesSecondary outcomesPrimary outcomeCare unitClinical outcomesIntraoperative managementLarge RCTsCochrane LibraryClinical trialsCognitive dysfunctionObservational study
2017
Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery
Grant MC, Hanna A, Benson A, Hobson D, Wu CL, Yuan CT, Rosen M, Wick EC. Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery. Journal Of The American College Of Surgeons 2017, 226: 267-276. PMID: 29274837, DOI: 10.1016/j.jamcollsurg.2017.12.010.Peer-Reviewed Original ResearchConceptsClinical outcomesProcess measure complianceEnhanced recoveryMeasure complianceOperating room teamSurgery programAnesthesia providersSurgical site infectionLength of stayHigh complianceColorectal surgeryERAS implementationERAS programSite infectionPerioperative careSurgery pathwayProvider teamProtocol elementsNurse anesthetistsIndividual providersDedicated teamOutcomesSignificant increaseSignificant reductionAnesthesiologists