2022
Patient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study
Galarza-Prado A, Zorrilla-Vaca A, Healy R, Ripollés J, Abad-Motos A, Nozal-Mateo B, Del Rio S, Caballero-Lozada A, Stone A, Mena G, Grant M. Patient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study. Journal Of Gastrointestinal Surgery 2022, 26: 911-916. PMID: 35059982, DOI: 10.1007/s11605-021-05234-4.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseColorectal surgeryPreoperative hypoalbuminemiaPreoperative transfusionPatient characteristicsArtery diseaseHigh adherenceRecovery protocolMultivariable logistic regression analysisEnhanced recovery protocolMulticentric prospective studyLow complication rateLogistic regression analysisClinical characteristicsComplication rateMetastatic diseaseSurgical characteristicsCancer resectionSurgery guidelinesProspective studyAdequate adherenceUnivariate analysisLow adherenceMultivariable modelPatients
2021
Institutional factors associated with adherence to enhanced recovery protocols for colorectal surgery: Secondary analysis of a multicenter study
Zorrilla-Vaca A, Stone A, Ripolles-Melchor J, Abad-Motos A, Ramirez-Rodriguez J, Galan-Menendez P, Mena G, Grant M, Group P, Garcia-Perez C, Higuera-Míguelez E, Marcos-Vidal J, Merino-García M, Rubio-López A, Pascual-Diez M, García-Miguel F, Cabezudo-Sanjose L, Martínez-Díaz R, Alegría-Rebollo S, González-Rodríguez J, Vega-Cruz M, Martínez-Ragüés G, Gómez-Ríos M, Mosquera-Rodríguez E, Del-Río-Regueira S, Bustos-García D, Sánchez-Conde M, Rodríguez-Calvo A, Hernández-Valero M, Angoso-Clavijo M, González-Fernández L, Bravo-Riaño M, Arnes-Muñoz M, Perez-Valdivieso J, Martin-Vizcaino M, Hernandez-Garcia S, Yoldi-Murillo F, Salvador-Bravo M, Rubial-Alvarez M, Oteiza-Martinez F, Balen-Rivera E, Garcia-Erce J, Zugasti-Murillo A, Petrina-Jáuregui M, Bustos-Molina F, Paz-Martín D, Vázquez-Vicente B, González-López L, Mínguez-Marín C, Diz-Jueguen S, Seoane-Antelo J, Ballinas-Miranda J, Carrera-Dacosta E, Barreiro-Domínguez E, Piñeiro-Teijeiro A, Sanchez-Santos R, Varela-Duran M, Diaz-Parada P, Calero-Lillo A, López-Lara M, Muñoz-Collado S, Valverde-Sintas J, Aznar-Puig S, Troyano-Escribano D, Marmaña-Mezquita S, Fernanz-Antón J, Catot-Alemany L, Balust J, Ubré M, Ferrando-Ortolá C, Martínez-Pallí G, Ibarzabal A, Lacy A, Sánchez-Martín R, Martins-Cruz K, Pérez-Jiménez P, Casans-Francés R, Longás J, Rodríguez J, Mugarra-Llopis A, Crisan C, Gracia-Ferrándiz E, Romero-Vargas E, Soro-Domingo M, Rodríguez-Jiménez R, Prada-Martin B, Muñoz-Hernández H, Herrera J, Cocho-Crespo S, Fernández-Caballero S, Flores-Crespo M, Vázquez-Fernández A, Brugiotti C, Ollé-Sese E, Houghton-Acuña C, López-Doucil M, Tarazona-López E, BEL-Marcobal I, González-Cogollor S, Llácer-Pérez M, Arias-Romano A, Arrabal-Taborda M, Caballero-Domínguez M, García-López R, Ontoria-Muriel J, Vivó-Blasco A, Blanco F, DEL-Cojo-Peces E, Tena-Guerrero J, Landaluce-Olavarria A, Badiola I, Calvo M, DE-Andres U, Portugal-Porras V, Ugarte-Sierra B, Pedregosa-Sanz A, Perelló-Cerdà L, Rodríguez-Téllez Y, Grössl-Meleán J, Viñas-Truñén X, Alday-Muñoz E, Bermejo-Marcos E, Alonso-Casado P, Gimeno-Calvo F, Rodriguez-Sánchez A, Montes-López C, Álvarez-Llano L, FAS-Vicent M, Ortega-Monzó J, Flores-Flores G, Tristancho J, Marmaña-Mezquita S, Bayo-Sans M, Deiros-Garcia M, Fernanz-Antón J, GIL-Gómez M, Parra L, Tejedor-DE-LA-Fuente V, Jericó-Alba C, Borrell-Brau N, Camacho-Martín D, Ortiz-DE-Zarate J, López-Ruiz D, Rodriguez-Bustamante V, Martinez-Vilalta M, Amoros-Ruiz D, Sadurni-Sarda M, Matas F, Giordano H, Peña J, Olmedilla-Arnal L, Benito-SAZ P, López-GIL E, Ruiz-Ortega A, Zapatero-García S, DEL-Valle-García E, Soria-Aledo V, Pérez-Guarinos C, Pellicer-Franco E, Valero-Navarro G, Mengual-Ballester M, García-Marín J, Romero-Simó M, Caravaca-García I, Blasco-Segura T, Campo-Betancourth C, Costa-Navarro R, Jordá-Sanz L, DE-Miguel-Cabrera M, España-Pamplona J, GIL-Trujillo S, Redondo-Calvo F, Baladrón-Gónzalez V, Moreno-Ballesteros R, Muñoz-Rodes J, Miranda E, Roselló-Chornet M, Alós-Zaragoza L, Catalá-Bauset J, Pallardo-López M, Almenara-Almenara N, Muñoz-Devesa L, Alcaide-Pardo B, Gimeno-Fernández P, Gómez-Agraz J, Iglesias-Morales C, Ordoñez-Enireb P, Ríos-Villalba A, Rodríguez-Pinto J, Sánchez-Cortés S, Montoya-Tabares M, Ruiz V, González-Sánchez F, Soriano-Giménez V, Muñoz-Camarena J, Benavides-Buleje J, Estupiñán-Jiménez J, Portero-Larragueta I, Alias D, Alberola-Estellés M, Díaz-Cambronero Ó, Matoses-Jaén M, Ruiz-Boluda M, Maristany-Bienert C, Pardo-López J, Ramiro-Ruiz Á, García P, Martínez-DE-Guereñu A, Montalbán B, Olea C, Benguría D, Silva J, Calderón A, Escoll-Rufino J, Cerdan-Santacruz C, Sierra-Grañón J, Rufas-Acín M, Mestres-Petit N, Penagos-Saavedra I, Moreno-Castilla C, Riera-RIU J, Cuellar-Martínez A, González-Álvarez R, Sánchez-Merchante M, García-DEL-Valle-Y-Manzano S, García-Zamorano S, Gijón-Herreros N, Robles-Ángel P, Logroño-Ejea M, Sanllorente-Sebastian R, Villalain-Perez M, Siclama-Stroe M, Benítez-Villar J, Sánchez-Campos A, Martínez-Ruiz A, Alonso-Carnicero P, DE-LA-Torre-González F, Naranjo-Checa C, Pereira-Pérez F, Ruiz-Ucar E, Rivera A, GIL-Lapetra C, Roca-Castillo E, Mariscal-Flores M, Morales-Cayuela M, Alonso-Ramos I, Jiménez-Carneros V, Casalduero-Garcia L, Jimenez-Miramón J, José L, Nogués-Ramia E, Sosa-Quesada Y, Gómez A, Martínez-Meco-Ortiz L, Cabellos-Olivares M, Rodríguez-Fraile J, Labalde-Martínez M, Ramos-Rodríguez, Nacarino-Alcorta B, Fernández-García R, DE-LA-Quintana-Gordon B, Drewniak J, Senra-L F, Galindo-Jara P, Gallardo-Herrera A, García-Llorente C, Colao-García L, Rellan-Álvarez L, Miro-Murillo M, Flores-Risco S, Serrat-Puyol J, Medina-Gallardo A, Mitsahid-Curbelo-Peña Y, Orenzana, Abad-Motos A, Abad-Gurumeta A, Aracil-Escoda N, Martínez-Hurtado E, Nozal-Mateo B, Sáez-Ruiz E, Salvachua-Fernández R, Ripollés-Melchor J, DE-Fuenmayor-Valera M, Sánchez E, Toribio B, Navarro-Sánchez A, López-Fernández J, Montesdeoca-Cabrera D, Alcalá-Serrano F, Sancho-DE-Avila A, Diaz-Carrasco S, Martín-Martín A, Suarez-DE-LA-Rica A, UÑA-Orejón R, Maseda E, Tejón-Pérez G, Alfaro-Martínez M, Alonso-Fernández M, Álvarez-Cebrián M, Álvarez-DEL-Vayo-Rodríguez M, Carrillo-Rivas M, Fernández-Rodríguez M, Trabanco-Morán S, Rábago-Morán J, Martínez-Ubieto J, Pascual-Bellosta A, Ortega-Lucea S, Santero-Ramirez M, Duque-Mallen M, Aragon-Benedi C, Vallejo-Tarrat A, Colillas-Calvet C, Laso M, Martinez-Cabañero J, Hernández-Salván J, Ledesma-Muñoz B, Ochoa-Osorio C, Sanz-García M, Herrero-Garrote B, Blázquez-Martin A, Díez-Alonso M, Hernández-Juara P, Muguerza-Huguet J, Barbero-Mielgo M, SAN-Antonio-SAN-Román B, Alonso-Aguilar L, Molnar V, Delgado-Naviero M, Meléndez-Leal E, Cavero-García V, Fernández-Sánchez Á, Cubek-Quevedo D, Munar R, Pradilla F, Serrano A, Balvís A, Berruezo A, Esparza E, HOZ I, Palavicini A, Pereira L, Vega X, Villahoz J, Villanueva G, Alonso-Fernández J, Aldecoa C, Bolaño-Pérez C, Villán-González T, Batalla A, Azparren G, Basttita M, Felipe M, Cueva L, Gine M, Gómez-Caro A, India I, Piñol S, Esteve-Pérez N, Mora-Fernández C, Ferrer-Robles A, Segura-Sampedro J, Alonso-Hernández N, Camps-Cervantes A, Chocrón-DA-Prat I, Coronado-Silva C, Duque-Santos H, Esclapez-Sempere E, Galan-Menéndez P, Matarín-Olmo S, Tormos-Pérez M, Villarino-Villa L, Bergés-Gutiérrez H, Aisa-Gasca M, Arbona-Camillero V, Bautista-González J, Carballido-Pascual F, Gutiérrez-Moreno M, Muñoz-Durán A, Cañete-Gómez J, Cáceres-Fabrega E, Lorente-Herce J, Mulet-Zayas O, Gómez-Pérez R, Monje-Salazar C, Lobato-Bancalero L, Torres-Moreno C, Sanchez-Cárdenas E, Daza-González J, Sanchez-Viguera T, DEL-Fresno-Asensio A, Bermudez-Román L, Jover-Pinillos J, Orts-Micó F, Cózar-Lozano C, Blasco-Delgado O, Nonnemacher-SAN-Julián A, Pérez J, Cruces L, Renedo-Corcóstegui P. Institutional factors associated with adherence to enhanced recovery protocols for colorectal surgery: Secondary analysis of a multicenter study. Journal Of Clinical Anesthesia 2021, 74: 110378. PMID: 34144497, DOI: 10.1016/j.jclinane.2021.110378.Peer-Reviewed Original ResearchConceptsEnhanced recovery protocolRegular multidisciplinary meetingsColorectal surgeryMultidisciplinary meetingCase volumeSecondary analysisFaster functional recoveryBetter patient satisfactionLow complication rateMultivariable linear regressionRecovery protocolHospital stayERAS implementationComplication rateFunctional recoveryMedian adherenceMulticenter studyPatient satisfactionMultivariable regressionNationwide studySurgery SocietyAnesthesia staffEnhanced recoveryMultidisciplinary teamSurgery
2020
Enhanced Recovery Programs for Colorectal Surgery and Postoperative Acute Kidney Injury: Results From a Systematic Review and Meta-Analysis of Observational Studies
Zorrilla-Vaca A, Mena G, Cata J, Healy R, Grant M. Enhanced Recovery Programs for Colorectal Surgery and Postoperative Acute Kidney Injury: Results From a Systematic Review and Meta-Analysis of Observational Studies. The American Surgeon 2020, 87: 1444-1451. PMID: 33375852, DOI: 10.1177/0003134820954846.Peer-Reviewed Original ResearchConceptsPostoperative acute kidney injuryAcute kidney injuryObservational studyKidney injuryColorectal surgeryConventional careSystematic reviewHigh-risk patient populationConventional perioperative carePerioperative health careRestrictive fluid administrationEnhanced recovery programmeRisk patient populationEvidence-based measuresHemodynamic goalsPostoperative recoveryERP patientsPerioperative careFluid administrationNephrotoxic agentsPatient populationPooled resultsGreater oddsRecovery programMeta-AnalysisGoal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Abad-Motos A, Aldecoa C, Lorente J, Ramirez-Rodriguez J, Grant M. Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study. The American Surgeon 2020, 87: 1189-1195. PMID: 33342254, DOI: 10.1177/0003134820973365.Peer-Reviewed Original ResearchConceptsGoal-directed fluid therapyEnhanced recovery programmeAcute kidney injurySurgical site infectionColorectal surgeryPostoperative outcomesFluid therapyPostoperative acute kidney injuryPropensity score-matched analysisComparable baseline demographicsMajor postoperative outcomesAdequate tissue perfusionRates of morbidityHospital stayKidney injuryBaseline demographicsCohort studyConventional careERAS programAnastomotic dehiscenceMajor surgerySite infectionPulmonary edemaMulticenter studyTherapy patientsRisk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Lorente J, Ramirez-Rodriguez J, Grant M. Risk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery. Surgery Today 2020, 51: 537-544. PMID: 32785846, DOI: 10.1007/s00595-020-02107-2.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge FactorsAgedAged, 80 and overColonCreatinineDigestive System Surgical ProceduresEnhanced Recovery After SurgeryFemaleHumansMaleMalnutritionMiddle AgedMulticenter Studies as TopicNutritional StatusPostoperative ComplicationsProspective StudiesRectumRisk FactorsROC CurveSerum AlbuminConceptsPostoperative acute kidney injuryAcute kidney injuryColorectal surgeryRisk factorsKidney injuryLow preoperative albumin levelRecovery pathwaysPerioperative patient outcomesPreoperative albumin levelEnhanced recovery pathwayIndependent risk factorProspective cohort studyPoor clinical outcomeDirect healthcare costsOpen surgical approachMalnourished patientsCohort studyAlbumin levelsASA IIILarge multicenterPreoperative interventionClinical outcomesMultivariable analysisOverall incidenceModifiable factorsCardiac Enhanced Recovery After Surgery: A Guide to Team Building and Successful Implementation
Salenger R, Morton-Bailey V, Grant M, Gregory A, Williams J, Engelman D. Cardiac Enhanced Recovery After Surgery: A Guide to Team Building and Successful Implementation. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 187-196. PMID: 32120008, DOI: 10.1053/j.semtcvs.2020.02.029.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresClinical CompetenceCooperative BehaviorDelivery of Health Care, IntegratedEnhanced Recovery After SurgeryHumansInterdisciplinary CommunicationOrganizational InnovationPatient Care TeamPatient-Centered CareProgram DevelopmentRecovery of FunctionTime FactorsTreatment OutcomeConceptsEnhanced recoveryCardiac programApplication of ERASEffect of ERASNormal functional statusLength of stayCompleteness of recoveryPostoperative complicationsColorectal surgeryERAS programCardiac surgeryPerioperative careFunctional statusSurgeryPatientsPhysiologic stressSurgical subspecialtiesERASStaff satisfactionMultiple studiesPatient-centered systemCareComplicationsStay
2019
Enhanced Recovery after Surgery for Colorectal Surgery: A Review of the Economic Implications
Stone A, Grant M, Wu C, Wick E. Enhanced Recovery after Surgery for Colorectal Surgery: A Review of the Economic Implications. Clinics In Colon And Rectal Surgery 2019, 32: 129-133. PMID: 30833862, PMCID: PMC6395088, DOI: 10.1055/s-0038-1676478.Peer-Reviewed Original ResearchHospital-acquired infectionsColorectal surgeryERAS programEnhanced recoverySuccessful ERAS programsSurgical site infectionQuality Improvement ProgramPerioperative protocolSite infectionSurgery programSurgeryFrontline providersPotential cost savingsHospitalInfectionHospital executivesStayCost savingsImprovement programsOverall lengthERAS
2017
Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery
Grant MC, Hanna A, Benson A, Hobson D, Wu CL, Yuan CT, Rosen M, Wick EC. Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery. Journal Of The American College Of Surgeons 2017, 226: 267-276. PMID: 29274837, DOI: 10.1016/j.jamcollsurg.2017.12.010.Peer-Reviewed Original ResearchConceptsClinical outcomesProcess measure complianceEnhanced recoveryMeasure complianceOperating room teamSurgery programAnesthesia providersSurgical site infectionLength of stayHigh complianceColorectal surgeryERAS implementationERAS programSite infectionPerioperative careSurgery pathwayProvider teamProtocol elementsNurse anesthetistsIndividual providersDedicated teamOutcomesSignificant increaseSignificant reductionAnesthesiologistsOptimizing an Enhanced Recovery Pathway Program: Development of a Postimplementation Audit Strategy
Grant M, Galante D, Hobson D, Lavezza A, Friedman M, Wu C, Wick E. Optimizing an Enhanced Recovery Pathway Program: Development of a Postimplementation Audit Strategy. The Joint Commission Journal On Quality And Patient Safety 2017, 43: 524-533. PMID: 28942777, DOI: 10.1016/j.jcjq.2017.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersClinical ProtocolsDigestive System Surgical ProceduresElectronic Health RecordsFemaleGroup ProcessesHumansLength of StayMaleMiddle AgedOrganizational CulturePatient Care BundlesPatient Care TeamPerioperative CarePostoperative ComplicationsQuality Indicators, Health CareRetrospective StudiesSafety ManagementConceptsLength of stayOverall LOSAverage LOSProcess measuresThree-month followProcess measure complianceAcademic medical centerSystem-level interventionsSignificant reductionElectronic health recordsColorectal surgeryConsecutive patientsPathway implementationEarly mobilityMeasure complianceMedical CenterPreventable harmOne-year periodPatientsRecovery pathwaysHealth recordsSystem-level changesSurgeryComplianceSame procedureIs enhanced recovery enough for reducing 30-d readmissions after surgery?
Fabrizio A, Grant M, Siddiqui Z, Alimi Y, Gearhart S, Wu C, Efron J, Wick E. Is enhanced recovery enough for reducing 30-d readmissions after surgery? Journal Of Surgical Research 2017, 217: 45-53. PMID: 28602223, DOI: 10.1016/j.jss.2017.04.007.Peer-Reviewed Original ResearchConceptsEnhanced recovery pathwaySurgical site infectionSite infectionSingle tertiary care centerPostoperative surgical site infectionIndex hospitalization lengthTertiary care centerEnhanced recovery programmeLength of stayTransitions of carePatient care experiencesColorectal surgeryReadmission ratesReduced readmissionsHospitalization lengthRetrospective studyCare transitionsCare centerPatient outcomesReadmissionSymptom monitoringSimilar cohortEnhanced recoveryHome transfersCare experiencesThoracic Epidural Anesthesia and Prophylactic Three Times Daily Unfractionated Heparin Within an Enhanced Recovery After Surgery Pathway for Colorectal Surgery
Stone A, Grant M, Lau B, Hobson D, Streiff M, Haut E, Wu C, Wick E. Thoracic Epidural Anesthesia and Prophylactic Three Times Daily Unfractionated Heparin Within an Enhanced Recovery After Surgery Pathway for Colorectal Surgery. Regional Anesthesia & Pain Medicine 2017, 42: 197-203. PMID: 28079734, DOI: 10.1097/aap.0000000000000542.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAnalgesia, EpiduralAnesthesia, EpiduralAnticoagulantsBaltimoreCatheters, IndwellingColonDatabases, FactualDevice RemovalDigestive System Surgical ProceduresDrug Administration ScheduleEarly AmbulationHeparinHumansProgram EvaluationRectumRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeVenous ThromboembolismConceptsThoracic epidural analgesiaVTE prophylaxisEpidural removalERAS programVenous thromboembolismTEA patientsHeparin dosesEpidural analgesiaSurgery pathwayPerioperative thoracic epidural analgesiaColorectal surgery patientsDose of UFHOptimal VTE prophylaxisPercent of patientsThoracic epidural anesthesiaEpidural catheter placementSingle academic centerPreoperative dosesThrombohemorrhagic complicationsColorectal surgeryEpidural hematomaNeuraxial analgesiaSurgery patientsSurgical indicationsUnfractionated heparinImpact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections
Grant M, Yang D, Wu C, Makary M, Wick E. Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections. Annals Of Surgery 2017, 265: 68-79. PMID: 28009729, DOI: 10.1097/sla.0000000000001703.Peer-Reviewed Original ResearchConceptsHealthcare-associated infectionsSurgical site infectionUrinary tract infectionLung infectionFTS protocolFast-track surgery pathwaysFast-track surgery protocolMajor healthcare-associated infectionPostoperative lung infectionLength of staySignificant reductionPostoperative incidenceHospital lengthColorectal surgerySurgery protocolTract infectionsPerioperative carePrimary outcomeSite infectionRandomized trialsSurgery pathwayPelvic surgerySubgroup analysisSurgical careHigh risk
2014
Enhanced Recovery After Surgery Protocols for Open Hepatectomy—Physiology, Immunomodulation, and Implementation
Page A, Ejaz A, Spolverato G, Zavadsky T, Grant M, Galante D, Wick E, Weiss M, Makary M, Wu C, Pawlik T. Enhanced Recovery After Surgery Protocols for Open Hepatectomy—Physiology, Immunomodulation, and Implementation. Journal Of Gastrointestinal Surgery 2014, 19: 387-399. PMID: 25472030, DOI: 10.1007/s11605-014-2712-0.Peer-Reviewed Original ResearchConceptsApplication of ERASBlood product transfusionImplementation of ERASUse of opioidsPerioperative inflammationERAS protocolPerioperative outcomesProduct transfusionColorectal surgeryERAS principlesInflammatory stressorsPerioperative protocolSurgery protocolBlood lossPerioperative fastingBiliary surgeryEnhanced recoverySurgical communitySurgeryNormal physiologyHepatectomyERASSubspecialty fieldsLaparotomyOpioids