The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting
Grant M, Betz M, Hulse M, Zorrilla-Vaca A, Hobson D, Wick E, Wu C. The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 123: 1100-1107. PMID: 27464972, DOI: 10.1213/ane.0000000000001404.Peer-Reviewed Original ResearchConceptsPreoperative pregabalinPostoperative nauseaPostoperative visual disturbancesPrevention of PONVSimilar antiemetic efficacyHigh-risk surgerySignificant reductionAdjuvant medicationsAntiemetic efficacyProphylactic antiemeticsThiopental inductionOpioid analgesiaPostoperative painSurgery protocolVisual disturbancesRandomized trialsRepeat dosingGeneral anesthesiaSubgroup analysisPregabalinEnhanced recoveryPONVNauseaVomitingTrialsThe Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting
Grant M, Lee H, Page A, Hobson D, Wick E, Wu C. The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 122: 976-985. PMID: 26991615, DOI: 10.1213/ane.0000000000001120.Peer-Reviewed Original ResearchConceptsPreoperative gabapentinPrimary end pointEnd pointPostoperative nauseaSide effectsPrevention of PONVHigh-risk surgerySignificant reductionGabapentin administrationPostoperative sedationThiopental inductionOpioid analgesiaPostoperative painAntiemetic effectRepeat dosingGeneral anesthesiaSubgroup analysisPONVPooled effectNauseaVomitingGabapentinPrimary analysisSecondary analysisTrials