2020
Cardiac Enhanced Recovery After Surgery: A Guide to Team Building and Successful Implementation
Salenger R, Morton-Bailey V, Grant M, Gregory A, Williams J, Engelman D. Cardiac Enhanced Recovery After Surgery: A Guide to Team Building and Successful Implementation. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 187-196. PMID: 32120008, DOI: 10.1053/j.semtcvs.2020.02.029.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresClinical CompetenceCooperative BehaviorDelivery of Health Care, IntegratedEnhanced Recovery After SurgeryHumansInterdisciplinary CommunicationOrganizational InnovationPatient Care TeamPatient-Centered CareProgram DevelopmentRecovery of FunctionTime FactorsTreatment OutcomeConceptsEnhanced recoveryCardiac programApplication of ERASEffect of ERASNormal functional statusLength of stayCompleteness of recoveryPostoperative complicationsColorectal surgeryERAS programCardiac surgeryPerioperative careFunctional statusSurgeryPatientsPhysiologic stressSurgical subspecialtiesERASStaff satisfactionMultiple studiesPatient-centered systemCareComplicationsStay
2019
Predictors of new persistent opioid use after coronary artery bypass grafting
Clement K, Canner J, Lawton J, Whitman G, Grant M, Sussman M. Predictors of new persistent opioid use after coronary artery bypass grafting. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 954-963.e4. PMID: 32007246, DOI: 10.1016/j.jtcvs.2019.09.137.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAmbulatory CareAnalgesics, OpioidCoronary Artery BypassDatabases, FactualDrug Administration ScheduleDrug PrescriptionsFemaleHumansMaleMiddle AgedOpioid-Related DisordersPain, PostoperativePractice Patterns, Physicians'Retrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsNew persistent opioid usePersistent opioid useCoronary artery bypassArtery bypassOpioid useOpioid prescriptionsPerioperative periodNaïve patientsChronic obstructive pulmonary diseaseAmount of opioidsAppropriate opioid prescribingObstructive pulmonary diseaseMultivariable logistic regressionPrescription opioid overdosePrior substance abuseInsurance claims dataOpioid requirementsOutpatient opioidsOpioid prescribingCardiac surgeryPulmonary diseaseOpioid dependenceProspective studyRisk factorsFemale genderPerioperative Dextrose Infusion and Postoperative Nausea and Vomiting
Zorrilla-Vaca A, Marmolejo-Posso D, Stone A, Li J, Grant MC. Perioperative Dextrose Infusion and Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30649067, DOI: 10.1213/ane.0000000000004019.Peer-Reviewed Original ResearchConceptsPostoperative nauseaDextrose infusionAntiemetic administrationGlucose levelsPlasma glucose monitoringPostoperative antiemetic administrationRescue antiemetic requirementsFurther prospective trialsPostanesthesia care unitSerum glucose levelsPlasma glucose levelsSignificant reductionAntiemetic requirementsPostoperative hyperglycemiaProspective trialSecondary outcomesPostoperative infusionPrimary outcomeCare unitCochrane LibraryUse of dextroseNauseaVomitingInfusionSignificant associationAmerican Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Management of Patients on Preoperative Opioid Therapy
Edwards D, Hedrick T, Jayaram J, Argoff C, Gulur P, Holubar S, Gan T, Mythen M, Miller T, Shaw A, Thacker J, McEvoy M, Geiger T, Gordon D, Grant M, Grocott M, Gupta R, Hah J, Hurley R, Kent M, King A, Oderda G, Sun E, Wu C. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Management of Patients on Preoperative Opioid Therapy. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30768461, DOI: 10.1213/ane.0000000000004018.Peer-Reviewed Original ResearchConceptsOpioid-related complicationsPerioperative managementConsensus recommendationsPerioperative Quality Initiative Joint Consensus StatementJoint consensus statementPerioperative treatment strategiesChronic opioid useHigh-risk groupPathways of careStandard of careHealth care providersHealth care teamOpioid therapyPreoperative opioidsMultimodal analgesiaPerioperative outcomesOpioid usePain specialistsRisk patientsCare management practicesElective surgeryFree anesthesiaOpioid dependenceRisk stratificationCare teamAmerican Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Opioid Minimization in Opioid-Naïve Patients.
Wu C, King A, Geiger T, Grant M, Grocott M, Gupta R, Hah J, Miller T, Shaw A, Gan T, Thacker J, Mythen M, McEvoy M. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Opioid Minimization in Opioid-Naïve Patients. Anesthesia & Analgesia 2019, 129: 567-577. PMID: 31082966, PMCID: PMC7261519, DOI: 10.1213/ane.0000000000004194.Peer-Reviewed Original ResearchConceptsPersistent postoperative opioid useOpioid-naïve patientsPostoperative opioid useOpioid-free anesthesiaOpioid useOpioid minimizationPerioperative Quality Initiative Joint Consensus StatementNew persistent postoperative opioid useJoint consensus statementOpioid-based medicationsPerioperative opioid useEnhanced recovery pathwayQuality InitiativePerioperative periodPain interventionsConsensus statementConsensus recommendationsSurgical careConsensus documentEnhanced recoverySuperior outcomesRecovery pathwaysDelphi processAmerican SocietyAnesthesiaEvidence Review Conducted for the Agency for Healthcare Research and Quality Safety Program for Improving Surgical Care and Recovery
Grant M, Gibbons M, Ko C, Wick E, Cannesson M, Scott M, McEvoy M, King A, Wu C. Evidence Review Conducted for the Agency for Healthcare Research and Quality Safety Program for Improving Surgical Care and Recovery. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30113392, DOI: 10.1213/ane.0000000000003696.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesiaBariatric SurgeryEvidence-Based MedicineHealth Services ResearchHumansOutcome and Process Assessment, Health CarePatient SafetyPostoperative ComplicationsPractice Guidelines as TopicQuality ImprovementQuality Indicators, Health CareRecovery of FunctionRisk AssessmentRisk FactorsTreatment OutcomeConceptsBariatric surgeryQuality Safety ProgramSurgical careHealthcare ResearchJohns Hopkins Medicine Armstrong InstituteEvidence reviewAvailable evidenceSafety programHospital staySurgery protocolPostoperative phaseSociety guidelinesAnesthetic interventionsAnesthetic componentsArmstrong InstituteAmerican CollegeSurgeryEnhanced recoverySuperior outcomesLiterature searchPatient safetyFacilitate recoveryCareInterventionOutcomesEvidence Review Conducted for the Agency for Healthcare Research and Quality Safety Program for Improving Surgical Care and Recovery
Ban K, Gibbons M, Ko C, Wick E, Cannesson M, Scott M, Grant M, Wu C. Evidence Review Conducted for the Agency for Healthcare Research and Quality Safety Program for Improving Surgical Care and Recovery. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 29649026, DOI: 10.1213/ane.0000000000003366.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesiaAnesthesiologyAnti-Bacterial AgentsAntibiotic ProphylaxisCarbohydratesColorectal NeoplasmsColorectal SurgeryEvidence-Based MedicineFluid TherapyHumansPatient SafetyPerioperative CarePiperidinesQuality of Health CareRandomized Controlled Trials as TopicSafety ManagementSurgical Procedures, OperativeThromboembolismTreatment OutcomeUnited StatesUnited States Agency for Healthcare Research and QualityUrinary Tract InfectionsConceptsSurgical careJohns Hopkins Medicine Armstrong InstituteCatheter-associated urinary tract infectionsGoal-directed fluid therapyHealthcare ResearchMultimodal analgesic regimensVenous thromboembolic eventsSurgical site infectionUrinary tract infectionQuality Safety ProgramProfessional associations/societiesGuidelines/recommendationsAssociation/SocietyAnalgesic regimensAntibiotic prophylaxisEvidence-based processThromboembolic eventsTract infectionsBlood transfusionCarbohydrate loadingPerioperative careSite infectionPostoperative phaseFluid therapySurgical outcomesImpact of Preoperative Erythropoietin on Allogeneic Blood Transfusions in Surgical Patients
Cho B, Serini J, Zorrilla-Vaca A, Scott M, Gehrie E, Frank S, Grant M. Impact of Preoperative Erythropoietin on Allogeneic Blood Transfusions in Surgical Patients. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30649068, DOI: 10.1213/ane.0000000000004005.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionAllogeneic blood transfusionBlood cell transfusionAllogeneic red blood cell transfusionPerioperative allogeneic blood transfusionBlood transfusionPreoperative erythropoietinCell transfusionThromboembolic eventsPatient blood management programPreoperative erythropoietin administrationSubset of patientsBlood management programPerioperative hemoglobin levelsErythropoietic stimulating agentsLength of stayErythropoietin useSecondary outcomesSurgical patientsThromboembolic complicationsBlood lossPrimary outcomeHemoglobin levelsRisk of exposureInpatient hospitalizationThe Impact of Anesthesia-Influenced Process Measure Compliance on Length of Stay
Grant M, Pio Roda C, Canner J, Sommer P, Galante D, Hobson D, Gearhart S, Wu C, Wick E. The Impact of Anesthesia-Influenced Process Measure Compliance on Length of Stay. Anesthesia & Analgesia 2019, 128: 68-74. PMID: 29782405, DOI: 10.1213/ane.0000000000003458.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnesthesiaAnesthesiologistsColonDigestive System Surgical ProceduresFemaleGuideline AdherenceHumansInterdisciplinary CommunicationLength of StayMaleMiddle AgedOutcome and Process Assessment, Health CarePatient Care TeamPerioperative CarePractice Guidelines as TopicPractice Patterns, Physicians'Program EvaluationQuality ImprovementQuality Indicators, Health CareRecovery of FunctionRectumTime FactorsTreatment OutcomeConceptsProcess measure complianceMeasure complianceProcess measuresAcute pain servicePain medication useLength of staySpecific process measuresImpact of complianceBreakthrough painHospital lengthPain serviceSurgery cohortERAS programSurgical encountersConsecutive patientsMedication usePerioperative careShorter LOSAnesthesia protocolImproved outcomesMultivariable regressionSurgery programEnhanced recoveryPatientsLOS
2017
Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections
Grant M, Yang D, Wu C, Makary M, Wick E. Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections. Annals Of Surgery 2017, 265: 68-79. PMID: 28009729, DOI: 10.1097/sla.0000000000001703.Peer-Reviewed Original ResearchMeSH KeywordsCross InfectionHumansLength of StayPerioperative CarePostoperative ComplicationsTreatment OutcomeConceptsHealthcare-associated infectionsSurgical site infectionUrinary tract infectionLung infectionFTS protocolFast-track surgery pathwaysFast-track surgery protocolMajor healthcare-associated infectionPostoperative lung infectionLength of staySignificant reductionPostoperative incidenceHospital lengthColorectal surgerySurgery protocolTract infectionsPerioperative carePrimary outcomeSite infectionRandomized trialsSurgery pathwayPelvic surgerySubgroup analysisSurgical careHigh riskThoracic Epidural Anesthesia and Prophylactic Three Times Daily Unfractionated Heparin Within an Enhanced Recovery After Surgery Pathway for Colorectal Surgery
Stone A, Grant M, Lau B, Hobson D, Streiff M, Haut E, Wu C, Wick E. Thoracic Epidural Anesthesia and Prophylactic Three Times Daily Unfractionated Heparin Within an Enhanced Recovery After Surgery Pathway for Colorectal Surgery. Regional Anesthesia & Pain Medicine 2017, 42: 197-203. PMID: 28079734, DOI: 10.1097/aap.0000000000000542.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAnalgesia, EpiduralAnesthesia, EpiduralAnticoagulantsBaltimoreCatheters, IndwellingColonDatabases, FactualDevice RemovalDigestive System Surgical ProceduresDrug Administration ScheduleEarly AmbulationHeparinHumansProgram EvaluationRectumRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeVenous ThromboembolismConceptsThoracic epidural analgesiaVTE prophylaxisEpidural removalERAS programVenous thromboembolismTEA patientsHeparin dosesEpidural analgesiaSurgery pathwayPerioperative thoracic epidural analgesiaColorectal surgery patientsDose of UFHOptimal VTE prophylaxisPercent of patientsThoracic epidural anesthesiaEpidural catheter placementSingle academic centerPreoperative dosesThrombohemorrhagic complicationsColorectal surgeryEpidural hematomaNeuraxial analgesiaSurgery patientsSurgical indicationsUnfractionated heparin
2016
The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting
Grant M, Betz M, Hulse M, Zorrilla-Vaca A, Hobson D, Wick E, Wu C. The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 123: 1100-1107. PMID: 27464972, DOI: 10.1213/ane.0000000000001404.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsHumansPostoperative Nausea and VomitingPregabalinPreoperative CareRandomized Controlled Trials as TopicTreatment OutcomeConceptsPreoperative pregabalinPostoperative nauseaPostoperative visual disturbancesPrevention of PONVSimilar antiemetic efficacyHigh-risk surgerySignificant reductionAdjuvant medicationsAntiemetic efficacyProphylactic antiemeticsThiopental inductionOpioid analgesiaPostoperative painSurgery protocolVisual disturbancesRandomized trialsRepeat dosingGeneral anesthesiaSubgroup analysisPregabalinEnhanced recoveryPONVNauseaVomitingTrialsThe Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting
Grant M, Lee H, Page A, Hobson D, Wick E, Wu C. The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 122: 976-985. PMID: 26991615, DOI: 10.1213/ane.0000000000001120.Peer-Reviewed Original ResearchConceptsPreoperative gabapentinPrimary end pointEnd pointPostoperative nauseaSide effectsPrevention of PONVHigh-risk surgerySignificant reductionGabapentin administrationPostoperative sedationThiopental inductionOpioid analgesiaPostoperative painAntiemetic effectRepeat dosingGeneral anesthesiaSubgroup analysisPONVPooled effectNauseaVomitingGabapentinPrimary analysisSecondary analysisTrialsThe Impact of Neuraxial Versus General Anesthesia on the Incidence of Postoperative Surgical Site Infections Following Knee or Hip Arthroplasty
Zorrilla-Vaca A, Grant MC, Mathur V, Li J, Wu CL. The Impact of Neuraxial Versus General Anesthesia on the Incidence of Postoperative Surgical Site Infections Following Knee or Hip Arthroplasty. Regional Anesthesia & Pain Medicine 2016, 41: 555-563. PMID: 27380106, DOI: 10.1097/aap.0000000000000437.Peer-Reviewed Original ResearchConceptsPostoperative surgical site infectionSurgical site infectionKnee arthroplastyHip arthroplastySite infectionNeuraxial anesthesiaGeneral anesthesiaSubgroup analysisOdds ratioDevelopment of SSIPooled unadjusted odds ratioUnadjusted odds ratioLarge observational trialsRandom-effects modelOverall beneficial effectObservational trialAnesthetic techniqueAnesthesia techniquesJoint arthroplastyInclusion criteriaTrial designArthroplastyMeta-AnalysisAnesthesiaPotential association
2009
A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery
Desai P, Kurian D, Thirumavalavan N, Desai S, Ziu P, Grant M, White C, Landis R, Poston R. A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery. Anesthesia & Analgesia 2009, 109: 1387-1394. PMID: 19843776, PMCID: PMC2789288, DOI: 10.1213/ane.0b013e3181b81068.Peer-Reviewed Original ResearchMeSH KeywordsAprotininBlood CoagulationBlood Coagulation TestsBlood PlateletsCoronary Artery Bypass, Off-PumpDouble-Blind MethodErythrocyte TransfusionFibrinolytic AgentsGraft Occlusion, VascularHumansPeptide FragmentsPlatelet AdhesivenessPlatelet AggregationPlatelet Function TestsPostoperative HemorrhageProspective StudiesProthrombinReceptor, PAR-1ThrombinThrombosisTreatment OutcomeWound HealingConceptsMajor adverse cardiovascular eventsProtease-activated receptor 1Adverse cardiovascular eventsSaphenous vein graftsCardiovascular eventsOPCAB surgeryAprotinin groupCoronary sinusHypercoagulable stateVein graftsThrombin generationAntifibrinolytic propertiesPump coronary artery bypass surgeryOff-pump coronary surgeryCoronary artery bypass surgeryRed blood cell transfusionAprotinin-treated patientsFull-dose regimenArtery bypass surgeryBlood cell transfusionCoronary sinus bloodPAR-1 antagonistsPlatelet-leukocyte conjugatesPAR-1 activationPlatelet-derived microparticles
2007
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass
Kon Z, Brown E, Tran R, Joshi A, Reicher B, Grant M, Kallam S, Burris N, Connerney I, Zimrin D, Poston R. Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass. Journal Of Thoracic And Cardiovascular Surgery 2007, 135: 367-375. PMID: 18242270, PMCID: PMC2962576, DOI: 10.1016/j.jtcvs.2007.09.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceCase-Control StudiesCohort StudiesCoronary AngiographyCoronary Artery Bypass, Off-PumpCoronary StenosisFemaleFollow-Up StudiesHumansInternal Mammary-Coronary Artery AnastomosisLength of StayLogistic ModelsMaleMiddle AgedPain, PostoperativePilot ProjectsPostoperative ComplicationsProbabilityRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexTime FactorsTomography, X-Ray ComputedTreatment OutcomeVascular PatencyConceptsPump coronary artery bypassCoronary artery bypassTarget vessel patencyActivation of coagulationArtery bypassMyocardial injuryHybrid procedureOff-pump coronary artery bypassMultivessel coronary artery diseaseSimultaneous hybrid coronary revascularizationLeft internal thoracic arteryHybrid coronary revascularizationInternal thoracic arteryCoronary artery diseaseIntensive care unitBetter perioperative outcomesEnzyme-linked immunosorbentPromising preliminary findingsOverall total costTranscardiac gradientCoronary revascularizationPerioperative morbidityPerioperative outcomesPostoperative morbidityArtery disease