2024
Area Vulnerability and Disparities in Therapy for Patients With Metastatic Renal Cell Carcinoma
Rahman S, Long J, Westvold S, Leapman M, Spees L, Hurwitz M, McManus H, Gross C, Wheeler S, Dinan M. Area Vulnerability and Disparities in Therapy for Patients With Metastatic Renal Cell Carcinoma. JAMA Network Open 2024, 7: e248747. PMID: 38687479, PMCID: PMC11061765, DOI: 10.1001/jamanetworkopen.2024.8747.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaArea-level measuresRenal cell carcinomaPatient-level factorsSystemic therapyEthnic disparitiesRelative risk ratiosSocially vulnerable areasCell carcinomaMeasures of social vulnerabilityMedicare beneficiariesCohort studyFee-for-service Medicare Parts AOdds ratioReceipt of systemic therapyLogistic regressionArea-level characteristicsAssociated with lack of treatmentNon-Hispanic blacksRetrospective cohort studyIndividual-level demographicsNon-Hispanic whitesAssociated with disparitiesUS Medicare beneficiariesMeasures of disadvantage
2023
Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma
Chow R, Long J, Hassan S, Wheeler S, Spees L, Leapman M, Hurwitz M, McManus H, Gross C, Dinan M. Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma. JNCI Cancer Spectrum 2023, 7: pkad036. PMID: 37202354, PMCID: PMC10276895, DOI: 10.1093/jncics/pkad036.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Renal CellEthnicityFemaleHumansKidney NeoplasmsMaleMedicareUnited StatesWhiteConceptsOral anticancer agentsTherapy utilizationMedicare beneficiariesNon-Hispanic white raceMetastatic renal cell carcinomaNon-Hispanic black raceOlder US patientsUS Medicare beneficiariesRenal cell carcinomaLogistic regression modelsTherapy receiptMultivariable adjustmentSystemic therapyMale sexUS patientsCell carcinomaStudy criteriaBlack raceFemale sexPatient raceWhite raceImmunotherapyOutcomes persistSexPatientsUse of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation
Leapman M, Wang R, Loeb S, Seibert T, Gaylis F, Lowentritt B, Brown G, Chen R, Lin D, Witte J, Cooperberg M, Catalona W, Gross C, Ma X. Use of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation. Journal Of Urology 2023, 209: 710-718. PMID: 36753746, DOI: 10.1097/ju.0000000000003159.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansMaleMedicareProstateProstate-Specific AntigenProstatic NeoplasmsRetrospective StudiesUnited StatesConceptsIntermediate-risk prostate cancerMixed-effects Poisson regressionPSA testingProstate biopsyProstate cancerEffects Poisson regressionMedicare beneficiariesPoisson regressionAdditional prostate biopsyRetrospective cohort studyProstate MRILocalized prostate cancerRepeat prostate biopsyRate of biopsyRace/ethnicityCensus tract povertyMedian followCohort studyMedian ageMonitoring testsProvider factorsPSA testClinical riskBiopsySociodemographic factorsAccess to urologic cancer care for Medicaid-insured patients
Laditi F, Nie J, Hsiang W, Umer W, Haleem A, Marks V, Buck M, Leapman M. Access to urologic cancer care for Medicaid-insured patients. Urologic Oncology Seminars And Original Investigations 2023, 41: 206.e21-206.e27. PMID: 36740488, DOI: 10.1016/j.urolonc.2023.01.014.Peer-Reviewed Original ResearchConceptsUrologic cancer careCancer careMedicaid insuranceMedicaid acceptanceAcceptance of MedicaidPrimary study outcomeNew Medicaid patientsMedicaid expansion statusNon-expansion statesState Medicaid programsMedicare reimbursement ratesAffordable Care ActVulnerable patientsMedicaid patientsHospital statusKidney tumorsNew diagnosisPatientsHealthcare accessExpansion statusFacility characteristicsNon-teaching facilitiesStudy outcomesAmerican Hospital DirectoryMedicaidProstate cancer disparities among American Indians and Alaskan Natives in the United States
Chu C, Leapman M, Zhao S, Cowan J, Washington S, Cooperberg M. Prostate cancer disparities among American Indians and Alaskan Natives in the United States. Journal Of The National Cancer Institute 2023, 115: 413-420. PMID: 36629492, PMCID: PMC10086629, DOI: 10.1093/jnci/djad002.Peer-Reviewed Original ResearchConceptsProstate cancer-specific mortalityProstate-specific antigenAlaska Native patientsCancer-specific mortalityGleason scoreNative patientsDefinitive treatmentWhite patientsProstate cancerTreatment accessAlaska NativesProvider densityHigher prostate-specific antigenAdvanced prostate cancerPatterns of careExternal beam radiationAmerican IndiansProstate cancer disparitiesCounty-level demographicsHealth policy interventionsLower ratesMultivariable adjustmentBaseline characteristicsPathologic factorsWorse survival
2022
End-of-Life Care for Patients With Metastatic Renal Cell Carcinoma in the Era of Oral Anticancer Therapy
Dzimitrowicz H, Wilson L, Jackson B, Spees L, Baggett C, Greiner M, Kaye D, Zhang T, George D, Scales C, Pritchard J, Leapman M, Gross C, Dinan M, Wheeler S. End-of-Life Care for Patients With Metastatic Renal Cell Carcinoma in the Era of Oral Anticancer Therapy. JCO Oncology Practice 2022, 19: e213-e227. PMID: 36413741, PMCID: PMC9970274, DOI: 10.1200/op.22.00401.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaOral anticancer agentsDays of lifeRenal cell carcinomaEOL careSystemic therapySEER-MedicareHospital deathCell carcinomaLife careIntensive care unit admissionCancer informationAggressive EOL careHigh-quality EOLOral anticancer therapySystemic therapy useCare unit admissionMultivariable logistic regressionQuality of endUnit admissionED visitsOlder patientsYounger patientsHospital admissionTherapy useIncidence of circumcision among insured adults in the United States
Nabavizadeh B, Li KD, Hakam N, Shaw NM, Leapman MS, Breyer BN. Incidence of circumcision among insured adults in the United States. PLOS ONE 2022, 17: e0275207. PMID: 36251658, PMCID: PMC9576047, DOI: 10.1371/journal.pone.0275207.Peer-Reviewed Original ResearchMeSH KeywordsAdultBalanitisCeremonial BehaviorCircumcision, MaleHumansIncidenceMalePhimosisUnited StatesConceptsAdult circumcisionIncidence rateAge-standardized incidence ratesIncidence of circumcisionAverage incidence rateYears of ageWide geographic variationInsured adultsCommon indicationIBM MarketScanMean ageDiseases codesInternational ClassificationHigh incidenceAge groupsIncidenceStudy periodCircumcisionRitual circumcisionUnited StatesPhimosisSurgeryBalanoposthitisHigh rateFuture studiesAcceptance of Simulated Adult Patients With Medicaid Insurance Seeking Care in a Cancer Hospital for a New Cancer Diagnosis
Marks VA, Hsiang WR, Nie J, Demkowicz P, Umer W, Haleem A, Galal B, Pak I, Kim D, Salazar MC, Berger ER, Boffa DJ, Leapman MS. Acceptance of Simulated Adult Patients With Medicaid Insurance Seeking Care in a Cancer Hospital for a New Cancer Diagnosis. JAMA Network Open 2022, 5: e2222214. PMID: 35838668, PMCID: PMC9287756, DOI: 10.1001/jamanetworkopen.2022.22214.Peer-Reviewed Original ResearchConceptsNew cancer diagnosesMedicaid insuranceCancer careAdult patientsSkin cancerComprehensive community cancer programsMultivariable logistic regression modelMedicaid acceptanceCancer-accredited facilitiesCancer diagnosisCommunity cancer programsBreast cancer carePopulation of patientsState Medicaid expansion statusCancer care servicesFacility-level factorsAbility of patientsAmerican Hospital Association Annual SurveyMedicaid expansion statusHigh-quality careLogistic regression modelsCancer HospitalCommon cancerFindings highlight gapsCancer programs
2017
Active Surveillance in Younger Men With Prostate Cancer
Leapman MS, Cowan JE, Nguyen HG, Shinohara KK, Perez N, Cooperberg MR, Catalona WJ, Carroll PR. Active Surveillance in Younger Men With Prostate Cancer. Journal Of Clinical Oncology 2017, 35: jco.2016.68.005. PMID: 28346806, PMCID: PMC5466007, DOI: 10.1200/jco.2016.68.0058.Peer-Reviewed Original ResearchConceptsBiopsy-based Gleason scoreActive surveillanceAssociation of ageProstate cancerDefinitive treatmentRadical prostatectomyYounger patientsGleason scoreMultivariable Cox proportional hazards regressionYounger ageLow-risk prostate cancerCox proportional hazards regressionGleason score upgradeInitial active surveillanceRelated end pointsCox regression analysisKaplan-Meier methodYounger patient ageProportional hazards regressionPrimary study objectiveInitial biopsyMedian agePatient ageHazards regressionBiochemical outcomes
2016
Pathological and Biochemical Outcomes among African-American and Caucasian Men with Low Risk Prostate Cancer in the SEARCH Database: Implications for Active Surveillance Candidacy
Leapman MS, Freedland SJ, Aronson WJ, Kane CJ, Terris MK, Walker K, Amling CL, Carroll PR, Cooperberg MR. Pathological and Biochemical Outcomes among African-American and Caucasian Men with Low Risk Prostate Cancer in the SEARCH Database: Implications for Active Surveillance Candidacy. Journal Of Urology 2016, 196: 1408-1414. PMID: 27352635, PMCID: PMC5542578, DOI: 10.1016/j.juro.2016.06.086.Peer-Reviewed Original ResearchConceptsAfrican American raceLow-risk prostate cancerAfrican American menRisk prostate cancerCaucasian manProstate cancerPathological upgradingBiochemical recurrenceFive-year recurrence-free survival ratesClinical low‐risk prostate cancerClinical low-risk diseaseRecurrence-free survival ratesCox proportional hazards analysisBiochemical recurrence outcomesEqual-access health systemLow-risk diseaseCohort of patientsLow-risk tumorsPositive surgical marginsProportional hazards analysisSearch databasesSEARCH cohortRecurrence outcomesRisk diseaseRisk tumors