2024
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis
Ogino N, Leite M, Guerra M, Kruglov E, Asashima H, Hafler D, Ito T, Pereira J, Peiffer B, Sun Z, Ehrlich B, Nathanson M. Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Journal Of Clinical Investigation 2024, 134: e171691. PMID: 38916955, PMCID: PMC11324315, DOI: 10.1172/jci171691.Peer-Reviewed Original ResearchAlcohol-associated hepatitisReduced cell proliferationCalcium channel expressionCalcium signaling mechanismsIntracellular calcium channelsCell proliferationRegulate calcium signalingNeutrophil extracellular trapsChannel expressionNeutrophil granule proteinsCalcium channelsNeutrophil infiltrationPatient specimensGranule proteasesMouse modelHealthy subjectsLiver diseaseExtracellular trapsCalcium signalingSerpin E2NeutrophilsElastase activityHepatitisTissue remodelingSignaling mechanisms
2013
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver
Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 2013, 59: 274-283. PMID: 23839970, PMCID: PMC3823683, DOI: 10.1002/hep.26609.Peer-Reviewed Original ResearchConceptsInsulin's metabolic effectsInsulin's mitogenic effectsInsulin receptorCell proliferationMitogenic effectMetabolic effectsInsulin-induced increaseFormation of inositolHepatic glucose metabolismInsulin's abilityFormation of InsP3Potential targetPathwayTherapeutic modulationGlucose metabolismProliferationInsP3Partial hepatectomyHepatic mitogenLiver growthLiver regenerationNucleusClathrinReceptorsLiver
2007
c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦
Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦. Journal Of Biological Chemistry 2007, 283: 4344-4351. PMID: 18073207, PMCID: PMC2825875, DOI: 10.1074/jbc.m706550200.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorC-MetAdaptor protein Gab1Protein Gab1C-Met signalingImportin beta1Plasma membraneReceptor c-MetBisphosphate hydrolysisCell proliferationCalcium signalsPathwayTrisphosphate formationGrowth factorCytoplasmTranslocationNucleusGab1PhosphatidylinositolSignalingInositolDifferentiationProliferationMembraneBeta1