2014
Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes
Amaya MJ, Oliveira AG, Schroeder LK, Allgeyer ES, Bewersdorf J, Nathanson MH. Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes. PLOS ONE 2014, 9: e114043. PMID: 25437447, PMCID: PMC4250053, DOI: 10.1371/journal.pone.0114043.Peer-Reviewed Original Research
2013
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver
Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 2013, 59: 274-283. PMID: 23839970, PMCID: PMC3823683, DOI: 10.1002/hep.26609.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium SignalingCell NucleusCell ProliferationInositol 1,4,5-TrisphosphateInsulinLiver RegenerationMaleRatsRats, Sprague-DawleyReceptor, InsulinConceptsInsulin's metabolic effectsInsulin's mitogenic effectsInsulin receptorCell proliferationMitogenic effectMetabolic effectsInsulin-induced increaseFormation of inositolHepatic glucose metabolismInsulin's abilityFormation of InsP3Potential targetPathwayTherapeutic modulationGlucose metabolismProliferationInsP3Partial hepatectomyHepatic mitogenLiver growthLiver regenerationNucleusClathrinReceptorsLiver
2003
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum
Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology 2003, 5: 440-446. PMID: 12717445, PMCID: PMC3572851, DOI: 10.1038/ncb980.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusCalciumCalcium ChannelsCalcium SignalingCell MembraneCell Nucleus StructuresCytosolEndoplasmic ReticulumEukaryotic CellsHumansInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMicroscopy, ConfocalNuclear EnvelopePhotochemistryProtein Kinase CProtein TransportReceptors, Cytoplasmic and NuclearTumor Cells, CulturedConceptsProtein kinase CNucleoplasmic reticulumCalcium signalsNuclear envelopeNuclear protein kinase CNuclear calcium signalsCytosolic protein kinase CGene transcriptionInduces translocationNuclear calcium storesPlasma membraneCytosolic calcium signalsSubnuclear regionsEndoplasmic reticulumSecond messengerKinase CTrisphosphate receptorCell growthReticulumNuclear componentsReticular networkPotential mechanismsCalcium storesRelease of calciumNucleus
1998
Type III InsP3 receptor channel stays open in the presence of increased calcium
Hagar R, Burgstahler A, Nathanson M, Ehrlich B. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998, 396: 81-84. PMID: 9817204, PMCID: PMC2825878, DOI: 10.1038/23954.Peer-Reviewed Original ResearchCoordination of calcium waves among hepatocytes: Teamwork gets the job done
Burgstahler A, Nathanson M. Coordination of calcium waves among hepatocytes: Teamwork gets the job done. Hepatology 1998, 27: 634-635. PMID: 9462668, DOI: 10.1002/hep.510270244.Peer-Reviewed Original ResearchAnimalsCalciumCell CommunicationGap JunctionsInositol 1,4,5-TrisphosphateLiverNorepinephrineRatsSignal Transduction
1993
Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes
Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCytosolGlucoseIn Vitro TechniquesInositol 1,4,5-TrisphosphateLiverMaleRatsRats, Sprague-DawleySignal TransductionTaurochenodeoxycholic AcidConceptsEffect of TUDCATauroursodeoxycholic acidAdministration of TUDCAIP3-independent mechanismCytosolic free calciumIP3-sensitive Ca2Trihydroxy bile acidsCholestatic disordersHepatocyte secretionTreatment periodExtracellular Ca2Bile acidsTaurolithocholic acidMumol/Rat hepatocytesFree calciumBasal levelsTransient increaseCytosolic Ca2Levels of inositolFree mediumPhysiological concentrationsIsolated rat hepatocytesHepatocytesFourfold increase