2023
Above the legal limit: Alcohol brings ER and mitochondria too close together
Guerra M, Nathanson M. Above the legal limit: Alcohol brings ER and mitochondria too close together. Cell Calcium 2023, 113: 102763. PMID: 37235972, PMCID: PMC10726477, DOI: 10.1016/j.ceca.2023.102763.Commentaries, Editorials and LettersMeSH KeywordsCalcium SignalingEndoplasmic ReticulumEndoplasmic Reticulum StressMitochondriaMitochondrial Membranes
2015
Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes
Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH. Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology 2015, 149: 211-222.e10. PMID: 25796361, PMCID: PMC4478166, DOI: 10.1053/j.gastro.2015.03.014.Peer-Reviewed Original ResearchConceptsBile ductBile duct unitsCholestatic disordersOxidative stressCalcium signalingNuclear factorMouse cholangiocytesDuct unitsReduced calcium signalingIntrahepatic bile ductsLevels of Nrf2Cholangiocyte cellsKnockdown of Nrf2Activation of Nrf2Intracellular calcium release channelsTranscription factor Nrf2Binding of Nrf2Calcium release channelPolymerase chain reaction analysisBiliary diseaseTrisphosphate receptorControl ratsLiver disordersBicarbonate secretionChain reaction analysis
2014
Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes
Amaya MJ, Oliveira AG, Schroeder LK, Allgeyer ES, Bewersdorf J, Nathanson MH. Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes. PLOS ONE 2014, 9: e114043. PMID: 25437447, PMCID: PMC4250053, DOI: 10.1371/journal.pone.0114043.Peer-Reviewed Original ResearchPost-translational Regulation of the Type III Inositol 1,4,5-Trisphosphate Receptor by miRNA-506*
Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. Post-translational Regulation of the Type III Inositol 1,4,5-Trisphosphate Receptor by miRNA-506*. Journal Of Biological Chemistry 2014, 290: 184-196. PMID: 25378392, PMCID: PMC4281721, DOI: 10.1074/jbc.m114.587030.Peer-Reviewed Original ResearchConceptsReporter activityMiR-506Trisphosphate receptorPost-translational regulationMiR-506 mimicsCell linesMiR-506 inhibitorEpigenetic regulationMiRNA regulationType III inositolFibrotic signatureMiR-506 expressionType III isoformCholangiocyte cell lineHEK293 cellsSitu hybridizationProtein levelsControl cellsInsP3R3H69 cellsRegulationSignalingExpressionCellsInositol
2013
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver
Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 2013, 59: 274-283. PMID: 23839970, PMCID: PMC3823683, DOI: 10.1002/hep.26609.Peer-Reviewed Original ResearchConceptsInsulin's metabolic effectsInsulin's mitogenic effectsInsulin receptorCell proliferationMitogenic effectMetabolic effectsInsulin-induced increaseFormation of inositolHepatic glucose metabolismInsulin's abilityFormation of InsP3Potential targetPathwayTherapeutic modulationGlucose metabolismProliferationInsP3Partial hepatectomyHepatic mitogenLiver growthLiver regenerationNucleusClathrinReceptorsLiver
2007
c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦
Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦. Journal Of Biological Chemistry 2007, 283: 4344-4351. PMID: 18073207, PMCID: PMC2825875, DOI: 10.1074/jbc.m706550200.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorC-MetAdaptor protein Gab1Protein Gab1C-Met signalingImportin beta1Plasma membraneReceptor c-MetBisphosphate hydrolysisCell proliferationCalcium signalsPathwayTrisphosphate formationGrowth factorCytoplasmTranslocationNucleusGab1PhosphatidylinositolSignalingInositolDifferentiationProliferationMembraneBeta1
2003
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum
Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology 2003, 5: 440-446. PMID: 12717445, PMCID: PMC3572851, DOI: 10.1038/ncb980.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusCalciumCalcium ChannelsCalcium SignalingCell MembraneCell Nucleus StructuresCytosolEndoplasmic ReticulumEukaryotic CellsHumansInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMicroscopy, ConfocalNuclear EnvelopePhotochemistryProtein Kinase CProtein TransportReceptors, Cytoplasmic and NuclearTumor Cells, CulturedConceptsProtein kinase CNucleoplasmic reticulumCalcium signalsNuclear envelopeNuclear protein kinase CNuclear calcium signalsCytosolic protein kinase CGene transcriptionInduces translocationNuclear calcium storesPlasma membraneCytosolic calcium signalsSubnuclear regionsEndoplasmic reticulumSecond messengerKinase CTrisphosphate receptorCell growthReticulumNuclear componentsReticular networkPotential mechanismsCalcium storesRelease of calciumNucleus
1998
Type III InsP3 receptor channel stays open in the presence of increased calcium
Hagar R, Burgstahler A, Nathanson M, Ehrlich B. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998, 396: 81-84. PMID: 9817204, PMCID: PMC2825878, DOI: 10.1038/23954.Peer-Reviewed Original Research