2022
DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation
Jawad M, Afkhami M, Ding Y, Zhang X, Li P, Young K, Xu ML, Cui W, Zhao Y, Halene S, Al-Kali A, Viswanatha D, Chen D, He R, Zheng G. DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation. Frontiers In Oncology 2022, 12: 849376. PMID: 35296003, PMCID: PMC8918526, DOI: 10.3389/fonc.2022.849376.Peer-Reviewed Original ResearchWorse progression-free survivalProgression-free survivalMyelodysplastic syndromeAML transformationMyeloid neoplasmsMDS casesHigh riskR882 mutationsClonal hematopoiesisIndependent risk factorUnique clinicopathologic featuresTertiary medical institutionsDifferent treatment approachesUnique clinicopathologicExcess blastsSevere leukopeniaClinicopathologic featuresMutant patientsRisk factorsLarge cohortTherapeutic implicationsTreatment approachesClinical implicationsClinical-genomic databaseNeoplasms
2020
Cutaneous Involvement in Plasma Cell Myeloma
Panse G, Subtil A, McNiff JM, Glusac EJ, Ko CJ, Galan A, Myung P, Xu ML. Cutaneous Involvement in Plasma Cell Myeloma. American Journal Of Clinical Pathology 2020, 155: 106-116. PMID: 32885235, DOI: 10.1093/ajcp/aqaa122.Peer-Reviewed Original ResearchConceptsPlasma cell myelomaCutaneous involvementSquamous cell carcinomaAmyloid depositionCell carcinomaCell myelomaCases of PCMBone marrow involvementCyclin D1 immunoreactivityDisease-related deathLight chain restrictionCCND1 gene rearrangementMarrow involvementSkin involvementClinicopathologic featuresCytomorphologic spectrumCutaneous lesionsPoor outcomeCommon immunophenotypeChain restrictionClinical dataCytogenetic findingsOlder individualsGene rearrangementsMyeloma
2018
Small Cell Variant of Intravascular Large B‐Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis
Rahmani M, Halene S, Xu ML. Small Cell Variant of Intravascular Large B‐Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis. BioMed Research International 2018, 2018: 9413015. PMID: 29850589, PMCID: PMC5903319, DOI: 10.1155/2018/9413015.Peer-Reviewed Case Reports and Technical NotesConceptsIntravascular large B-cell lymphomaB-cell lymphomaLarge B-cell lymphomaSmall cell morphologySmall cell variantCases of IVLBCLCell variantHodgkin's B-cell lymphomaRandom skin biopsySmall bowel biopsyHigh clinical suspicionLarge atypical cellsSmall cell lymphomaSmall blood vesselsBowel biopsyClinical suspicionLymph nodesRetrospective reviewClinicopathologic featuresSmall bowelPoor prognosisAtypical cellsFallopian tubeSkin biopsiesDifferential diagnosis