Identification of a Cereblon-Independent Protein Degradation Pathway in Residual Myeloma Cells Treated with Immunomodulatory Drugs
Verma R, Mai Z, Xu M, Zhang L, Dhodapkar K, Dhodapkar M. Identification of a Cereblon-Independent Protein Degradation Pathway in Residual Myeloma Cells Treated with Immunomodulatory Drugs. Blood 2015, 126: 913. DOI: 10.1182/blood.v126.23.913.913.Peer-Reviewed Original ResearchResidual MM cellsDegradation of IKZF1MM cellsClonogenic growthRNAi-mediated inhibitionHDAC inhibitorsMyeloma cellsResidual myeloma cellsSynergistic anti-tumor effectImmune-modulatory drugsHuman MM cellsPrimary MM cellsAnti-myeloma effectTrichostatin AMM plasma cellsAnti-tumor effectsMM cell linesAnti-proliferative effectsConcurrent therapyImmunomodulatory drugsResidual diseaseModulatory drugsPlasma cellsT cellsRecent studies