Featured Publications
Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping
Xu ML, Yang B, Carcangiu ML, Hui P. Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping. Modern Pathology 2008, 22: 232-238. PMID: 18820674, DOI: 10.1038/modpathol.2008.165.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Squamous CellComparative Genomic HybridizationDiagnosis, DifferentialEndometrial NeoplasmsEpithelioid CellsFemaleGene Expression Regulation, NeoplasticGenetic TestingGenotypeGestational Trophoblastic DiseaseHumansItalyLung NeoplasmsMiddle AgedPregnancyUnited StatesUterine Cervical NeoplasmsConceptsEpithelioid trophoblastic tumorTrophoblastic tumorSquamous cell carcinomaUterine cervixComparative genomic hybridizationCommon squamous cell carcinomaChromosomal alterationsInvasive squamous cell carcinomaChorionic-type intermediate trophoblastGestational trophoblastic diseaseGenomic hybridizationDNA genotypingIntermediate trophoblastTrophoblastic diseaseAnatomic locationComparative genomic hybridization analysisTrophoblastic originTumorsGenomic hybridization analysisCervixNormal tissuesTrophoblastic natureConventional comparative genomic hybridizationCarcinomaChromosomal profile
2022
IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas
McQuaid DC, Katz SG, Xu ML. IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas. American Journal Of Clinical Pathology 2022, 158: 173-176. PMID: 35460405, PMCID: PMC10664184, DOI: 10.1093/ajcp/aqac044.Peer-Reviewed Original Research
2020
T-cell and NK-cell lymphomas in the lung
Pan Z, Xu ML. T-cell and NK-cell lymphomas in the lung. Seminars In Diagnostic Pathology 2020, 37: 273-282. PMID: 32448591, DOI: 10.1053/j.semdp.2020.04.003.Peer-Reviewed Original ResearchConceptsT-cell lymphomaWorld Health Organization classificationNK-cell lymphomasAdequate antibiotic therapyTypical radiologic featuresPrinciples of treatmentDifferent histologic typesPrecise pathologic diagnosisHilar adenopathyEmpirical antibioticsSystemic lymphomaWedge biopsyAntibiotic therapyLymphomas accountRadiologic featuresRadiologic findingsBronchoscopic examinationHistologic typePleural effusionClinical symptomsRecurrent infectionsCystic changesOrganization classificationPathologic diagnosisPulmonary opacities
2019
EBV-Positive Primary Large B-Cell Lymphoma: The Role of Immunohistochemistry and XPO1 in the Diagnosis of Mediastinal Lymphomas
Maracaja DLV, Puthenpura V, Pels SG, O’Malley D, Sklar JL, Finberg KE, Xu ML. EBV-Positive Primary Large B-Cell Lymphoma: The Role of Immunohistochemistry and XPO1 in the Diagnosis of Mediastinal Lymphomas. Applied Immunohistochemistry & Molecular Morphology 2019, 28: 725-730. PMID: 31789821, DOI: 10.1097/pai.0000000000000820.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkers, TumorDiagnosis, DifferentialEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumansImmunohistochemistryImmunophenotypingKaryopherinsLymphoma, Large B-Cell, DiffuseMaleMediastinal NeoplasmsMutationReceptors, Cytoplasmic and NuclearThymus NeoplasmsYoung AdultConceptsPrimary mediastinal large B-cell lymphomaEpstein-Barr virusLarge B-cell lymphomaB-cell lymphomaEBV positivityMediastinal lymphomaMediastinal large B-cell lymphomaMediastinal gray zone lymphomaGray zone lymphomaRole of immunohistochemistryClassical Hodgkin lymphomaEBV expressionMediastinal massTherapeutic optionsHodgkin's lymphomaClassic immunophenotypeLymphomaXPO1 mutationsMutational profilingPositivityNext-generation sequencingImmunophenotypeSomatic mutationsK mutationTumorsALCL by any other name: the many facets of anaplastic large cell lymphoma
Irshaid L, Xu ML. ALCL by any other name: the many facets of anaplastic large cell lymphoma. Pathology 2019, 52: 100-110. PMID: 31706671, DOI: 10.1016/j.pathol.2019.09.007.Peer-Reviewed Original ResearchMeSH KeywordsDiagnosis, DifferentialGene RearrangementHumansLymphoma, Large-Cell, AnaplasticPhenotypePrognosisReceptor Protein-Tyrosine KinasesConceptsAnaplastic large cell lymphomaAnaplastic lymphoma kinaseALK gene translocationALK(-) ALCLLarge cell lymphomaALK gene rearrangementVariable prognosisFavorable prognosisCell lymphomaGene rearrangementsNon-Hodgkin T-cell lymphomaExtent of diseaseLarge lymphoma cellsT-cell lymphomaGene translocationSpecific gene rearrangementsPatient demographicsIntermediate prognosisDismal prognosisImmunohistochemical phenotypeClinical behaviorFavorable outcomeDifferential diagnosisImplant placementSkin lesionsPhiladelphia chromosome‐negative acute leukemia in patients with chronic myeloid leukemia
Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S. Philadelphia chromosome‐negative acute leukemia in patients with chronic myeloid leukemia. American Journal Of Hematology 2019, 94: e256-e259. PMID: 31273842, DOI: 10.1002/ajh.25571.Peer-Reviewed Original ResearchAbnormal KaryotypeAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBlast CrisisBone MarrowChromosome AberrationsDiagnosis, DifferentialDiagnostic ErrorsFemaleFollow-Up StudiesHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteMaleMiddle AgedMyelodysplastic SyndromesNeoplasms, Second PrimaryPhiladelphia ChromosomeRetrospective StudiesYoung AdultHistiocytic and Dendritic Cell Neoplasms
Pan Z, Xu ML. Histiocytic and Dendritic Cell Neoplasms. Surgical Pathology Clinics 2019, 12: 805-829. PMID: 31352989, DOI: 10.1016/j.path.2019.03.013.Peer-Reviewed Original ResearchConceptsDendritic cell neoplasm
2018
Be careful of the masquerades: differentiating secondary myelodysplasia from myelodysplastic syndromes in clinical practice
Shallis RM, Xu ML, Podoltsev NA, Curtis SA, Considine BT, Khanna SR, Siddon AJ, Zeidan AM. Be careful of the masquerades: differentiating secondary myelodysplasia from myelodysplastic syndromes in clinical practice. Annals Of Hematology 2018, 97: 2333-2343. PMID: 30109425, DOI: 10.1007/s00277-018-3474-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultDiagnosis, DifferentialFemaleHematologic NeoplasmsHumansMaleMiddle AgedMyelodysplastic SyndromesConceptsMyelodysplastic syndromeSecondary myelodysplasiaSecondary causesAllogeneic hematopoietic cell transplantationDiagnosis of MDSRepresentative case seriesUnderlying myelodysplastic syndromeHematopoietic cell transplantationLack of efficacyHematologists/oncologistsMeticulous exclusionResultant cytopeniasIntensive chemotherapyCase seriesMorphologic reviewCell transplantationDiagnostic dilemmaSuch therapyMalignant processExpert hematopathologistsClinical practiceMyelodysplasiaCytogenetic abnormalitiesPatientsSpecialized physicians
2017
Lymph node stromal and vascular proliferations
Xu ML, O’Malley D. Lymph node stromal and vascular proliferations. Seminars In Diagnostic Pathology 2017, 35: 67-75. PMID: 29173940, DOI: 10.1053/j.semdp.2017.11.004.Peer-Reviewed Original Research
2014
Institutional Review of Primary Non-Hodgkin Lymphoma of the Female Genital Tract
Ahmad AK, Hui P, Litkouhi B, Azodi M, Rutherford T, McCarthy S, Xu ML, Schwartz PE, Ratner E. Institutional Review of Primary Non-Hodgkin Lymphoma of the Female Genital Tract. International Journal Of Gynecological Cancer 2014, 24: 1250-1255. PMID: 25010039, PMCID: PMC8139417, DOI: 10.1097/igc.0000000000000201.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBleomycinCombined Modality TherapyCyclophosphamideCytarabineDiagnosis, DifferentialDoxorubicinFemaleGenital Neoplasms, FemaleGynecologic Surgical ProceduresHumansLymphoma, Non-HodgkinMiddle AgedPrednisolonePrednisonePregnancyPregnancy Complications, NeoplasticRetrospective StudiesSurvival AnalysisTeniposideVincristineYoung AdultConceptsNon-Hodgkin lymphomaFemale genital tractGenital tractGynecologic malignanciesPara-aortic lymph nodesPrimary non-Hodgkin lymphomaDiffuse large B-cell lymphomaYale-New Haven HospitalLarge B-cell lymphomaConcomitant radiation therapyRadical gynecologic surgeryCommon histologic typeOverall median survivalSingle institution experienceStem cell transplantationRare gynecologic malignancyDiagnosis of lymphomaAnn Arbor systemB-cell lymphomaWorld Health OrganizationMedian survivalRecurrent diseaseCombination chemotherapyMedian ageUterine corpus
2013
Venting the Spleen
Varughese N, Duong A, Emre S, Xu M, Lee AI. Venting the Spleen. New England Journal Of Medicine 2013, 369: 1357-1363. PMID: 24088096, DOI: 10.1056/nejmcps1210943.Peer-Reviewed Original Research