2002
Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
Zhong M, Lu Z, Foster D. Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 2002, 21: 1071-1078. PMID: 11850824, DOI: 10.1038/sj.onc.1205165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCaspase 9CaspasesCell LineCell Line, TransformedCell SurvivalCulture Media, Serum-FreeCytochrome c GroupDown-RegulationIsoenzymesPhosphatidylinositol 3-KinasesProtein Kinase CProtein Kinase C-deltaProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins pp60(c-src)RatsSignal TransductionTetradecanoylphorbol AcetateConceptsSurvival signalsSerum withdrawalPKC δApoptotic signalsTyrosine kinase c-SrcProtein kinase C δC-Src overexpressionKinase c-SrcCaspase-9 pathwayV-SrcRenders cellsApoptotic phenotypeApoptotic stressC-SrcSurvival pathwaysRat fibroblastsDownregulationApoptosisCellsPathwayOverexpressionPhenotypeFibroblastsSignals
2001
Novel tumor-promoting property of tamoxifen.
Zhong M, Lu Z, Abbas T, Hornia A, Chatakondu K, Barile N, Kaplan P, Foster D. Novel tumor-promoting property of tamoxifen. Molecular Cancer Research 2001, 12: 187-92. PMID: 11331247.Peer-Reviewed Original ResearchConceptsTumor-promoting capabilitiesEstrogen antagonist propertiesEstrogen-mimetic effectsEffect of tamoxifenBreast cancer patientsYears of treatmentTumor-promoting phorbol ester TPATumor-promoting propertiesC-Src overexpressionEndometrial cancerCancer patientsRat fibroblastsTamoxifenPhorbol ester TPA