2006
Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 1936-1940. PMID: 16449385, PMCID: PMC1413666, DOI: 10.1073/pnas.0510710103.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkOverexpression of PLD1Mutant neuronsPhospholipase D1Beta-amyloid precursor proteinIntracellular traffickingPS1-deficient cellsPLD enzymatic activityTherapeutic targetNeuronal functionPS1 mutationsOverexpression of WTBetaAPPPrecursor proteinMutant cellsSubcellular localizationNeurite outgrowthPLD1 activitySurface deliveryNeuronsOutgrowth capacityCellsTraffickingEnzymatic activityOverexpression
2003
Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells
Zhong M, Shen Y, Zheng Y, Joseph T, Jackson D, Foster D. Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Biochemical And Biophysical Research Communications 2003, 302: 615-619. PMID: 12615079, DOI: 10.1016/s0006-291x(03)00229-8.Peer-Reviewed Original ResearchConceptsHuman breast cancer cell linesSerum withdrawalBreast cancer cell linesMDA-MB-231 breast cancer cellsMDA-MB-231 cellsPLD activityBreast cancer cellsElevated PLD activityCancer cell linesTyrosine kinaseRat fibroblastsElevated expressionElevated levelsCancer cellsPhospholipase D activityCell linesWithdrawalApoptosisOncogenic signalsUndergo apoptosisD activityCellsFibroblastsApoptotic insultsPhospholipase D
2002
Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
Zhong M, Lu Z, Foster D. Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 2002, 21: 1071-1078. PMID: 11850824, DOI: 10.1038/sj.onc.1205165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCaspase 9CaspasesCell LineCell Line, TransformedCell SurvivalCulture Media, Serum-FreeCytochrome c GroupDown-RegulationIsoenzymesPhosphatidylinositol 3-KinasesProtein Kinase CProtein Kinase C-deltaProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins pp60(c-src)RatsSignal TransductionTetradecanoylphorbol AcetateConceptsSurvival signalsSerum withdrawalPKC δApoptotic signalsTyrosine kinase c-SrcProtein kinase C δC-Src overexpressionKinase c-SrcCaspase-9 pathwayV-SrcRenders cellsApoptotic phenotypeApoptotic stressC-SrcSurvival pathwaysRat fibroblastsDownregulationApoptosisCellsPathwayOverexpressionPhenotypeFibroblastsSignals