2019
Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma
Xu K, Budhai A, Pattarkine R, Zhong M. Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma. American Journal Of Clinical Pathology 2019, 152: s72-s73. DOI: 10.1093/ajcp/aqz113.087.Peer-Reviewed Original ResearchIHC stainsProstate cancerProstatic adenocarcinomaERG fusionNext-generation sequencingProstate adenocarcinoma casesTMA slidesE26 transformation-specific familyCommon genetic alterationsTissue microarray constructionAdenocarcinoma casesIHC stainingImmunohistochemistry stainsPositive casesMRNA level increasesTumor cellsNuclear stainingTCGA dataGenetic alterationsNontumor cellsSection slidesAdenocarcinomaCancerSurrogate testStain
2001
Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2
Joseph T, Wooden R, Bryant A, Zhong M, Lu Z, Foster D. Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2. Biochemical And Biophysical Research Communications 2001, 289: 1019-1024. PMID: 11741292, DOI: 10.1006/bbrc.2001.6118.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorTransformation of cellsTyrosine kinaseElevated tyrosine kinase activityElevated expressionTyrosine kinase activityGTPase cascadeMembrane microdomainsPhospholipase D activityTransform cellsPLD genesGrowth factor receptorC-SrcMitogenic signalsGene productsDownstream targetsKinase activityOncogenic signalingPhospholipase D1PLD2Common genetic alterationsHuman cancersKinaseMalignant phenotypeGenetic alterations