Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model*
Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight E, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich M, Robakis N, Gandy S, Cai D. Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model*. Journal Of Biological Chemistry 2013, 288: 32050-32063. PMID: 24052255, PMCID: PMC3814799, DOI: 10.1074/jbc.m113.504365.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsCell Line, TumorDisease Models, AnimalDown-RegulationGene Knockdown TechniquesHippocampusHumansLysosomesMiceMice, TransgenicMutationPeptide FragmentsPhosphatidylinositol 4,5-DiphosphatePhosphoric Monoester HydrolasesPresenilin-1ConceptsAmyloid precursor proteinNovel mechanismSwedish mutant amyloid precursor proteinSynaptojanin 1Aβ clearanceC-terminal fragmentΓ-secretase cleavageMouse modelIntracellular Aβ levelsCellular degradationAlzheimer's Disease Transgenic Mouse ModelFull-length amyloid precursor proteinSYNJ1Cellular clearanceMutant amyloid precursor proteinN2a cellsAlzheimer mouse modelPrecursor proteinTransgenic mouse modelReduced expressionPlaque loadAβ42 levelsAβ levelsTransgenic miceCognitive deterioration