2017
Identification of distinctive patterns in cell signaling pathways in glioblastoma multiforme subtypes using gene expression TCGA data sets.
Volyanskyy K, Zhong M, Keswarpu P, Fallon J, Fanucchi M, Dimitrova N. Identification of distinctive patterns in cell signaling pathways in glioblastoma multiforme subtypes using gene expression TCGA data sets. Journal Of Clinical Oncology 2017, 35: e23162-e23162. DOI: 10.1200/jco.2017.35.15_suppl.e23162.Peer-Reviewed Original ResearchGene expression profilesPredictive genesCancer Genome AtlasG-CIMPTranscriptomic patternsRNAseq dataJAK-STATExpression profilesPathway interactionsBiological pathwaysNormal tissuesPI3K-AktCalcium signalingGenesGBM subtypesGene selectionGenome AtlasPotential therapeutic targetTCGA data setsPathwayPathway involvementTumor progressionTherapeutic targetDetected interactionsSubtype differentiation
2002
Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
Zhong M, Lu Z, Foster D. Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 2002, 21: 1071-1078. PMID: 11850824, DOI: 10.1038/sj.onc.1205165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCaspase 9CaspasesCell LineCell Line, TransformedCell SurvivalCulture Media, Serum-FreeCytochrome c GroupDown-RegulationIsoenzymesPhosphatidylinositol 3-KinasesProtein Kinase CProtein Kinase C-deltaProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins pp60(c-src)RatsSignal TransductionTetradecanoylphorbol AcetateConceptsSurvival signalsSerum withdrawalPKC δApoptotic signalsTyrosine kinase c-SrcProtein kinase C δC-Src overexpressionKinase c-SrcCaspase-9 pathwayV-SrcRenders cellsApoptotic phenotypeApoptotic stressC-SrcSurvival pathwaysRat fibroblastsDownregulationApoptosisCellsPathwayOverexpressionPhenotypeFibroblastsSignals