A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners
Cai D, Guo L, Cao J, Zhang L, Huang M, Hou J, Zhu L, Julia T, Zhong M, Goate A, Zhang B. A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054111.Peer-Reviewed Original ResearchMolecular mechanismsGene co-expression network analysisCo-expression network analysisPossible post-translational modificationsGene perturbation studiesDimorphic expression patternPost-translational modificationsSystems biology approachSpecific mannerRNA expression datasetsKey driver genesSex-biased differenceMulti-omics dataSex-specific contributionsMultiscale network analysisLDL receptor-related proteinUptake of apoEBiology approachGene candidatesRegulator geneExpression patternsNetwork analysisReceptor-related proteinDriver genesExpression datasets