2020
A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression
Cai D, Huang M, Cao J, Hou J, Zhu L, Zhang L, Pero A, Guo L, Julia T, Zhong M, Goate A, Zhang B, Yan R. A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043247.Peer-Reviewed Original ResearchSynaptic functionAPOE genotypeEndo-lysosomal traffickingReticulon 3Strongest genetic risk factorWhole brain lysateNon-demented subjectsPostmortem brain samplesGenetic risk factorsAMP-AD consortiumDifferent brain regionsHuman postmortem brain samplesLOAD patientsRisk factorsAD pathogenesisMolecular signaling mechanismsSporadic ADDisease pathogenesisSynaptosomal fractionBrain samplesMouse brainApoE4Brain regionsCognitive functionSynaptojanin 1
2013
Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model*
Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight E, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich M, Robakis N, Gandy S, Cai D. Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model*. Journal Of Biological Chemistry 2013, 288: 32050-32063. PMID: 24052255, PMCID: PMC3814799, DOI: 10.1074/jbc.m113.504365.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsCell Line, TumorDisease Models, AnimalDown-RegulationGene Knockdown TechniquesHippocampusHumansLysosomesMiceMice, TransgenicMutationPeptide FragmentsPhosphatidylinositol 4,5-DiphosphatePhosphoric Monoester HydrolasesPresenilin-1ConceptsAmyloid precursor proteinNovel mechanismSwedish mutant amyloid precursor proteinSynaptojanin 1Aβ clearanceC-terminal fragmentΓ-secretase cleavageMouse modelIntracellular Aβ levelsCellular degradationAlzheimer's Disease Transgenic Mouse ModelFull-length amyloid precursor proteinSYNJ1Cellular clearanceMutant amyloid precursor proteinN2a cellsAlzheimer mouse modelPrecursor proteinTransgenic mouse modelReduced expressionPlaque loadAβ42 levelsAβ levelsTransgenic miceCognitive deterioration