2003
Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells
Zhong M, Shen Y, Zheng Y, Joseph T, Jackson D, Foster D. Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Biochemical And Biophysical Research Communications 2003, 302: 615-619. PMID: 12615079, DOI: 10.1016/s0006-291x(03)00229-8.Peer-Reviewed Original ResearchConceptsHuman breast cancer cell linesSerum withdrawalBreast cancer cell linesMDA-MB-231 breast cancer cellsMDA-MB-231 cellsPLD activityBreast cancer cellsElevated PLD activityCancer cell linesTyrosine kinaseRat fibroblastsElevated expressionElevated levelsCancer cellsPhospholipase D activityCell linesWithdrawalApoptosisOncogenic signalsUndergo apoptosisD activityCellsFibroblastsApoptotic insultsPhospholipase D
2002
Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts
Zhong M, Joseph T, Jackson D, Beychenok S, Foster D. Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts. Biochemical And Biophysical Research Communications 2002, 298: 474-477. PMID: 12408976, DOI: 10.1016/s0006-291x(02)02495-6.Peer-Reviewed Original ResearchConceptsElevated PLD expressionPLD expressionPhospholipase DRat fibroblastsElevated expressionProtein kinase C deltaNormal rat fibroblastsElevated phospholipase D activityInducible expression systemCytochrome c releaseMitochondrial apoptosis pathwayADP-ribose polymerasePhospholipase D activityC deltaApoptotic insultsC releaseExpression systemTyrosine kinase expressionTransient transfectionTyrosine kinaseApoptosis pathwayCell transformationPLD activityAbsence of serumCaspase-3Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
Zhong M, Lu Z, Foster D. Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 2002, 21: 1071-1078. PMID: 11850824, DOI: 10.1038/sj.onc.1205165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCaspase 9CaspasesCell LineCell Line, TransformedCell SurvivalCulture Media, Serum-FreeCytochrome c GroupDown-RegulationIsoenzymesPhosphatidylinositol 3-KinasesProtein Kinase CProtein Kinase C-deltaProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins pp60(c-src)RatsSignal TransductionTetradecanoylphorbol AcetateConceptsSurvival signalsSerum withdrawalPKC δApoptotic signalsTyrosine kinase c-SrcProtein kinase C δC-Src overexpressionKinase c-SrcCaspase-9 pathwayV-SrcRenders cellsApoptotic phenotypeApoptotic stressC-SrcSurvival pathwaysRat fibroblastsDownregulationApoptosisCellsPathwayOverexpressionPhenotypeFibroblastsSignals