2018
A Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction
Lee H, Sade I, Gilani S, Zhong M, Lombardo G. A Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction. The American Surgeon 2018, 84: 210-211. PMID: 30401014, DOI: 10.1177/000313481808400701.Peer-Reviewed Original Research
2016
Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma
Khani F, Diolombi M, Khattar P, Huang W, Fallon J, Epstein J, Zhong M. Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma. The American Journal Of Surgical Pathology 2016, 40: 1291-1295. PMID: 27299795, DOI: 10.1097/pas.0000000000000680.Peer-Reviewed Original ResearchConceptsTERT promoter mutationsTransitional cell differentiationMalignant Brenner tumorBrenner tumorUrothelial carcinomaPromoter mutationsMetastatic urothelial carcinomaTransitional cell metaplasiaParaffin-embedded tissue blocksUncommon ovarian neoplasmsPolymerase chain reaction sequencingDistinct pathogenesisCell metaplasiaOvarian neoplasmsPrognostic roleImmunophenotypical featuresFallopian tubeRare caseTransitional epitheliumCell differentiationDiagnostic utilityTumorsTissue blocksReaction sequencingMetaplasiaTFE3-Fusion Variant Analysis Defines Specific Clinicopathologic Associations Among Xp11 Translocation Cancers
Argani P, Zhong M, Reuter V, Fallon J, Epstein J, Netto G, Antonescu C. TFE3-Fusion Variant Analysis Defines Specific Clinicopathologic Associations Among Xp11 Translocation Cancers. The American Journal Of Surgical Pathology 2016, 40: 723-737. PMID: 26975036, PMCID: PMC4864095, DOI: 10.1097/pas.0000000000000631.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCarcinoma, Renal CellChildChild, PreschoolChromosomes, Artificial, BacterialChromosomes, Human, XFemaleHumansIn Situ Hybridization, FluorescenceKidney NeoplasmsMaleMelanomaMiddle AgedOncogene Proteins, FusionPerivascular Epithelioid Cell NeoplasmsTranslocation, GeneticYoung AdultConceptsRenal cell carcinomaGene fusionsMelanotic Xp11 translocation renal cancerXp11 translocation renal cell carcinomaTranslocation renal cell carcinomaBacterial artificial chromosome probesGene partnersClinicopathologic featuresClinicopathologic associationsRenal cancerFusion gene partnersClear cell papillary renal cell carcinomaPerivascular epithelioid cell tumorCathepsin KCellular contextPapillary renal cell carcinomaEpithelioid cell tumorRNA sequencingSpecific clinicopathologic featuresMesenchymal counterpartsIdentical gene fusionsOncogenic activationASPL-TFE3 gene fusionChromosome probesTFE3 gene fusions
2013
Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model*
Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight E, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich M, Robakis N, Gandy S, Cai D. Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model*. Journal Of Biological Chemistry 2013, 288: 32050-32063. PMID: 24052255, PMCID: PMC3814799, DOI: 10.1074/jbc.m113.504365.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsCell Line, TumorDisease Models, AnimalDown-RegulationGene Knockdown TechniquesHippocampusHumansLysosomesMiceMice, TransgenicMutationPeptide FragmentsPhosphatidylinositol 4,5-DiphosphatePhosphoric Monoester HydrolasesPresenilin-1ConceptsAmyloid precursor proteinNovel mechanismSwedish mutant amyloid precursor proteinSynaptojanin 1Aβ clearanceC-terminal fragmentΓ-secretase cleavageMouse modelIntracellular Aβ levelsCellular degradationAlzheimer's Disease Transgenic Mouse ModelFull-length amyloid precursor proteinSYNJ1Cellular clearanceMutant amyloid precursor proteinN2a cellsAlzheimer mouse modelPrecursor proteinTransgenic mouse modelReduced expressionPlaque loadAβ42 levelsAβ levelsTransgenic miceCognitive deteriorationB-Raf and the inhibitors: from bench to bedside
Huang T, Karsy M, Zhuge J, Zhong M, Liu D. B-Raf and the inhibitors: from bench to bedside. Journal Of Hematology & Oncology 2013, 6: 30. PMID: 23617957, PMCID: PMC3646677, DOI: 10.1186/1756-8722-6-30.Peer-Reviewed Original Research
2006
Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation
Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P. Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 1941-1946. PMID: 16449386, PMCID: PMC1413665, DOI: 10.1073/pnas.0510708103.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesCell LineEndopeptidasesGene Expression RegulationHumansMembrane ProteinsMiceMice, KnockoutPhospholipase DPresenilin-1Protein BindingProtein Processing, Post-TranslationalProtein TransportTrans-Golgi Network
2003
Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells
Zhong M, Shen Y, Zheng Y, Joseph T, Jackson D, Foster D. Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Biochemical And Biophysical Research Communications 2003, 302: 615-619. PMID: 12615079, DOI: 10.1016/s0006-291x(03)00229-8.Peer-Reviewed Original ResearchConceptsHuman breast cancer cell linesSerum withdrawalBreast cancer cell linesMDA-MB-231 breast cancer cellsMDA-MB-231 cellsPLD activityBreast cancer cellsElevated PLD activityCancer cell linesTyrosine kinaseRat fibroblastsElevated expressionElevated levelsCancer cellsPhospholipase D activityCell linesWithdrawalApoptosisOncogenic signalsUndergo apoptosisD activityCellsFibroblastsApoptotic insultsPhospholipase D
2001
Novel tumor-promoting property of tamoxifen.
Zhong M, Lu Z, Abbas T, Hornia A, Chatakondu K, Barile N, Kaplan P, Foster D. Novel tumor-promoting property of tamoxifen. Molecular Cancer Research 2001, 12: 187-92. PMID: 11331247.Peer-Reviewed Original ResearchConceptsTumor-promoting capabilitiesEstrogen antagonist propertiesEstrogen-mimetic effectsEffect of tamoxifenBreast cancer patientsYears of treatmentTumor-promoting phorbol ester TPATumor-promoting propertiesC-Src overexpressionEndometrial cancerCancer patientsRat fibroblastsTamoxifenPhorbol ester TPA