2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2021
The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts
Clark M, Jembere N, Kupets R. The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts. Preventive Medicine 2021, 150: 106641. PMID: 34048822, DOI: 10.1016/j.ypmed.2021.106641.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCondylomata AcuminataFemaleGenitaliaHumansOntarioPapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesUterine Cervical NeoplasmsVaccinationYoung AdultConceptsSchool-based human papillomavirus (HPV) vaccination programLower genital tract dysplasiaPre-invasive diseaseTreatment of HPVVaccination programGenital wartsCervical dysplasiaCytologic abnormalitiesRelative riskHuman papilloma virus vaccination programmesLow-grade cytologic abnormalitiesHuman papillomavirus vaccination programmeLower genital tractHigh-grade abnormalitiesRelative risk ratiosCervical conizationUnvaccinated womenVaccinated womenHPV vaccineColposcopy servicesUnvaccinated groupVaccinated groupRisk ratioCytology resultsAdministrative databasesSurvival of Older Women With Cervical Cancer Based on Screening History.
Clark M, Jembere N, Wang L, Kupets R. Survival of Older Women With Cervical Cancer Based on Screening History. Journal Of Lower Genital Tract Disease 2021, 25: 9-14. PMID: 33347044, DOI: 10.1097/lgt.0000000000000582.Peer-Reviewed Original ResearchMeSH KeywordsAgedEarly Detection of CancerFemaleHumansMiddle AgedNeoplasm StagingOntarioRegistriesRetrospective StudiesSurvival AnalysisUterine Cervical NeoplasmsVaginal SmearsConceptsInvasive cervical cancerWomen 50 yearsPrimary care physiciansCervical cancerOverall survivalScreening historyCare physiciansPopulation-level retrospective cohort studyMultivariate analysisHealth care administrative databasesFour-year OSRetrospective cohort studyCervical screening historyUnscreened womenAdvanced diseaseCohort studyScreened groupSurvival benefitImproved survivalCervical screeningKaplan-MeierUnivariate analysisAdministrative databasesOlder womenAge groups
2019
Limitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing?
Clark M, Lee A, Kupets R. Limitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing? Journal Of Obstetrics And Gynaecology Canada 2019, 41: 1410-1415. PMID: 30803876, DOI: 10.1016/j.jogc.2018.11.034.Peer-Reviewed Original ResearchConceptsPrimary care physiciansCare physiciansHealth care encountersCervical cancerCare encountersMore health care encountersRetrospective observational studyCervical cancer screeningHealth care servicesBasis of ageEligible womenCancer screeningAdministrative databasesObservational studyScreening programCare servicesHealth servicesPhysiciansCorrespondence programWomenFurther riskOutreach methodsCancerMailingInfrequent users