2017
Biological Age, Not Chronological Age, Is Associated with Late-Life Depression
Brown PJ, Wall MM, Chen C, Levine ME, Yaffe K, Roose SP, Rutherford BR. Biological Age, Not Chronological Age, Is Associated with Late-Life Depression. The Journals Of Gerontology Series A 2017, 73: 1370-1376. PMID: 28958059, PMCID: PMC6132120, DOI: 10.1093/gerona/glx162.Peer-Reviewed Original ResearchConceptsLate-life depressionCES-D scoresDepressive symptomsBaseline CES-D scoreBiological ageChronological ageCovariate-adjusted regression modelsOlder biological ageEpidemiologic Studies Depression ScaleSignificant depressive symptomsBody Composition StudyMean chronological ageAge-associated changesNumerous physiological systemsAge-related processesKidney functioningLife depressionDepression ScaleDepression groupBrain disordersHealth AgingLongitudinal associationsSymptomsAgeRegression models
2015
Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older
Arpawong TE, Lee J, Phillips DF, Crimmins EM, Levine ME, Prescott CA. Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. Behavior Genetics 2015, 46: 72-88. PMID: 26330209, PMCID: PMC4720538, DOI: 10.1007/s10519-015-9740-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesDepressionDepressive DisorderEthnicityFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansLife Change EventsMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalConceptsDepressive symptomsU.S. population-based studyRecent stressOlder adultsStress-diathesis hypothesisPopulation-based studySerotonin transporter gene promoter regionSingle nucleotide polymorphismsDepressive symptom levelsPopulation-based sampleAdults age 50Race/ethnicityAge 50Repeated-measures designSerotonin transporter polymorphismDepressive symptomatologySymptomsOlder individualsSymptom levelsReverse causationTransporter polymorphismMeasures studyDifferential effectsShort alleleStressful events
2014
A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults
Levine ME, Crimmins EM, Prescott CA, Phillips D, Arpawong TE, Lee J. A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults. Biodemography And Social Biology 2014, 60: 199-211. PMID: 25343367, PMCID: PMC4298361, DOI: 10.1080/19485565.2014.952705.Peer-Reviewed Original ResearchConceptsHigher CESD scoresPolygenic risk scoresCESD scoresDepressive symptomsEpidemiological Studies Depression Scale scoreWeighted polygenic risk scoreLogistic regression modelsReplication sampleMultinomial logistic regression modelsRisk scoreScale scoreDiscovery setIndividual susceptibilitySymptomsOlder adultsAnalytic sampleGenetic riskSingle nucleotide polymorphismsScoresRetirement StudyRegression modelsDepressionPercent increaseAssociationHigh levels