Loneliness, eudaimonia, and the human conserved transcriptional response to adversity
Cole SW, Levine ME, Arevalo JM, Ma J, Weir DR, Crimmins EM. Loneliness, eudaimonia, and the human conserved transcriptional response to adversity. Psychoneuroendocrinology 2015, 62: 11-17. PMID: 26246388, PMCID: PMC4637182, DOI: 10.1016/j.psyneuen.2015.07.001.Peer-Reviewed Original ResearchConceptsRisk factorsBehavioral health risk factorsCommunity-dwelling older adultsPeripheral blood samplesPro-inflammatory genesHealth risk factorsSocial isolationMixed effect linear model analysesChronic social adversityCTRA gene expressionStrength of associationGene expressionPsychological resilience factorsResilience factorsAdversity factorsBlood samplesIncreased expressionMeasures of lonelinessOlder adultsSocial adversityAnxiety symptomsUS HealthLinear model analysisRetirement StudyHealth risksChildhood and later life stressors and increased inflammatory gene expression at older ages
Levine ME, Cole SW, Weir DR, Crimmins EM. Childhood and later life stressors and increased inflammatory gene expression at older ages. Social Science & Medicine 2015, 130: 16-22. PMID: 25658624, PMCID: PMC4394113, DOI: 10.1016/j.socscimed.2015.01.030.Peer-Reviewed Original ResearchConceptsChildhood traumaLow SESPro-inflammatory gene expressionProinflammatory gene expression levelsEarly lifeLater lifeLife health outcomesInflammatory gene expressionLater-life health outcomesHigh riskInflammatory genesAdulthood adversityChildhood healthHealth outcomesAdverse experiencesAdult traumaOlder ageTraumaLate-life stressorsGene expressionElevated levelsFuture healthComposite scoreLife stressorsChildhood