A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans
Levine ME, Crimmins EM. A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans. The Journals Of Gerontology Series A 2015, 71: 703-712. PMID: 26355015, PMCID: PMC4888382, DOI: 10.1093/gerona/glv141.Peer-Reviewed Original ResearchConceptsFunctional interaction networkSingle nucleotide polymorphismsStress resistanceNucleotide polymorphismsInteraction networksGenome-wide association studiesPathway analysisAssociation studiesPolygenic risk scoresNetworks AssociatedBiological networksHuman longevityUnique phenotypeHuman agingGenesPolymorphismLongevityPhenotypeInnate resilienceRisk scoreAge 52Threefold increasePathwayWeighted polygenic risk scoreResistanceQuantification of biological aging in young adults
Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE. Quantification of biological aging in young adults. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4104-e4110. PMID: 26150497, PMCID: PMC4522793, DOI: 10.1073/pnas.1506264112.Peer-Reviewed Original ResearchConceptsYoung adultsYoung humansSame chronological ageSelf-reported bad healthCognitive declineOlder adultsBiological agingYoung individualsChronological ageMultiple organ systemsBrain agingLongitudinal measuresAge-related diseasesChronic diseasesAdultsFourth decadeBirth cohortOrgan systemsWorse healthIndividualsRejuvenation therapyTime pointsHuman agingMultiple biomarkersTherapy