2021
Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study
Xiao C, Beitler JJ, Peng G, Levine ME, Conneely KN, Zhao H, Felger JC, Wommack EC, Chico CE, Jeon S, Higgins KA, Shin DM, Saba NF, Burtness BA, Bruner DW, Miller AH. Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study. Cancer 2021, 127: 3361-3371. PMID: 34027995, DOI: 10.1002/cncr.33641.Peer-Reviewed Original ResearchConceptsC-reactive proteinIL-6 levelsEpigenetic age accelerationNeck cancerInterleukin-6Inflammatory markersHigher epigenetic age accelerationLower C-reactive proteinAge accelerationHigher C-reactive proteinMultidimensional Fatigue Inventory-20Poor functional outcomeBlood DNA methylationMonths postradiotherapyAdvanced diseaseConcurrent chemoradiationMost patientsDistant metastasisFunctional outcomeSevere fatigueTreatment completionRadiation therapyPatientsGreater fatigueInflammation
2020
Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions
Haghani A, Cacciottolo M, Doty KR, D'Agostino C, Thorwald M, Safi N, Levine ME, Sioutas C, Town TC, Forman HJ, Zhang H, Morgan TE, Finch CE. Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions. ELife 2020, 9: e54822. PMID: 32579111, PMCID: PMC7314548, DOI: 10.7554/elife.54822.Peer-Reviewed Original Research
2014
Not All Smokers Die Young: A Model for Hidden Heterogeneity within the Human Population
Levine M, Crimmins E. Not All Smokers Die Young: A Model for Hidden Heterogeneity within the Human Population. PLOS ONE 2014, 9: e87403. PMID: 24520332, PMCID: PMC3919713, DOI: 10.1371/journal.pone.0087403.Peer-Reviewed Original ResearchConceptsLung function levelsProportional hazards modelMost age groupsCurrent smokersSimilar inflammationNHANES IIIMortality riskSmokersAge 50Age 80Hazards modelExtreme old ageAge groupsMeans of biomarkersOlder ageResilient phenotypeHigh exposureFunction levelUnderstanding of heterogeneityDamaging factorsLongevity extensionAging processBiological advantagesSmokingInflammation
2012
Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation?
Levine ME, Crimmins EM. Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation? Current Gerontology And Geriatrics Research 2012, 2012: 826398. PMID: 22611388, PMCID: PMC3352243, DOI: 10.1155/2012/826398.Peer-Reviewed Original ResearchInsulin resistanceBody compositionAdults age 60Muscle massAge 60Non-obese older adultsCognitive functioningCognitive performanceOlder adultsSarcopenic nonobeseSarcopenic obeseHigh CRPSarcopenic obesityWorse cognitive functioningWaist circumferenceMultiple physiological systemsNHANES 1999Abdominal fatObesityMetabolic deregulationLower cognitionAdultsObeseSarcopeniaInflammation