2021
Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants
Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME. Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants. The Journals Of Gerontology Series A 2021, 76: e133-e141. PMID: 33684206, PMCID: PMC7989601, DOI: 10.1093/gerona/glab060.Peer-Reviewed Original ResearchConceptsCOVID-19 severity outcomeCOVID-19 severityDiseases/conditionsAge-related comorbid conditionsCOVID-19-related mortalityPrevalent chronic diseasesCOVID-19 infectionBiggest risk factorCOVID-19Severity outcomesUK Biobank participantsLogistic regression modelsComorbid conditionsTest positivityRisk factorsChronic diseasesInpatient settingFurther adjustmentSymptom severityEarly pandemicBiobank participantsDisease prevalenceAgeSeverityCOVID-19 pandemic
2014
A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults
Levine ME, Crimmins EM, Prescott CA, Phillips D, Arpawong TE, Lee J. A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults. Biodemography And Social Biology 2014, 60: 199-211. PMID: 25343367, PMCID: PMC4298361, DOI: 10.1080/19485565.2014.952705.Peer-Reviewed Original ResearchConceptsHigher CESD scoresPolygenic risk scoresCESD scoresDepressive symptomsEpidemiological Studies Depression Scale scoreWeighted polygenic risk scoreLogistic regression modelsReplication sampleMultinomial logistic regression modelsRisk scoreScale scoreDiscovery setIndividual susceptibilitySymptomsOlder adultsAnalytic sampleGenetic riskSingle nucleotide polymorphismsScoresRetirement StudyRegression modelsDepressionPercent increaseAssociationHigh levels