2021
Extending human healthspan and longevity: a symposium report
DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Annals Of The New York Academy Of Sciences 2021, 1507: 70-83. PMID: 34498278, PMCID: PMC10231756, DOI: 10.1111/nyas.14681.Peer-Reviewed Original ResearchConceptsAge-related diseasesEarly-stage clinical trialsField of geroscienceReduction of morbidityBiological agingEnd of lifeClinical trialsNovel agentsClinical developmentGeroscience hypothesisFDA approvalDrug evaluationMultiple disordersTherapyDiseaseSymposium reportConcept studyHuman healthspanHealthspanAging processSignificant barriersMorbidityDysfunctionAgingTrials
2015
Quantification of biological aging in young adults
Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE. Quantification of biological aging in young adults. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4104-e4110. PMID: 26150497, PMCID: PMC4522793, DOI: 10.1073/pnas.1506264112.Peer-Reviewed Original ResearchConceptsYoung adultsYoung humansSame chronological ageSelf-reported bad healthCognitive declineOlder adultsBiological agingYoung individualsChronological ageMultiple organ systemsBrain agingLongitudinal measuresAge-related diseasesChronic diseasesAdultsFourth decadeBirth cohortOrgan systemsWorse healthIndividualsRejuvenation therapyTime pointsHuman agingMultiple biomarkersTherapy