2022
Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock
Minteer C, Morselli M, Meer M, Cao J, Higgins‐Chen A, Lang SM, Pellegrini M, Yan Q, Levine ME. Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock. Aging Cell 2022, 21: e13553. PMID: 35104377, PMCID: PMC8844113, DOI: 10.1111/acel.13553.Peer-Reviewed Original ResearchConceptsMouse embryonic fibroblastsDNA methylationEpigenetic agingImportant chromatin regulatorsPolycomb group (PcG) factorsAnti-aging interventionsChromatin regulatorsEmbryonic fibroblastsCellular senescenceTissue agingCellular agingEpigenetic clocksMultiple tissuesMouse tissuesCaloric restrictionMechanistic insightsAging changesKidney fibroblastsReduced representationTime pointsPhysiological agingMouse culturesSuch alterationsTick-TockTissue
2015
Quantification of biological aging in young adults
Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE. Quantification of biological aging in young adults. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4104-e4110. PMID: 26150497, PMCID: PMC4522793, DOI: 10.1073/pnas.1506264112.Peer-Reviewed Original ResearchConceptsYoung adultsYoung humansSame chronological ageSelf-reported bad healthCognitive declineOlder adultsBiological agingYoung individualsChronological ageMultiple organ systemsBrain agingLongitudinal measuresAge-related diseasesChronic diseasesAdultsFourth decadeBirth cohortOrgan systemsWorse healthIndividualsRejuvenation therapyTime pointsHuman agingMultiple biomarkersTherapy