2017
Genetic architecture of epigenetic and neuronal ageing rates in human brain regions
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S. Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nature Communications 2017, 8: 15353. PMID: 28516910, PMCID: PMC5454371, DOI: 10.1038/ncomms15353.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingBrainBrain MappingCalcium-Binding ProteinsChildChild, PreschoolCognitive DysfunctionDNA MethylationEpigenesis, GeneticFemaleGenome, HumanGenome-Wide Association StudyHumansInfantMaleMiddle AgedNerve Tissue ProteinsNeurodegenerative DiseasesNeuronsQuantitative Trait LociConceptsGenome-wide association studiesCis-expression quantitative trait lociGenome-wide significant lociProportion of neuronsQuantitative trait lociEpigenetic aging ratesDNA methylation-based biomarkersEpigenetic agingMethylation-based biomarkersGenetic architectureTrait lociSignificant lociAssociation studiesBrain regionsAge-related macular degenerationType 2 diabetesAging rateGenesLociHuman brain regionsUlcerative colitisWaist circumferenceMacular degenerationParkinson's diseaseBrain samples
2012
Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation?
Levine ME, Crimmins EM. Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation? Current Gerontology And Geriatrics Research 2012, 2012: 826398. PMID: 22611388, PMCID: PMC3352243, DOI: 10.1155/2012/826398.Peer-Reviewed Original ResearchInsulin resistanceBody compositionAdults age 60Muscle massAge 60Non-obese older adultsCognitive functioningCognitive performanceOlder adultsSarcopenic nonobeseSarcopenic obeseHigh CRPSarcopenic obesityWorse cognitive functioningWaist circumferenceMultiple physiological systemsNHANES 1999Abdominal fatObesityMetabolic deregulationLower cognitionAdultsObeseSarcopeniaInflammation