2019
Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Liu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME. Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study. PLOS Medicine 2019, 16: e1002827. PMID: 31211779, PMCID: PMC6581243, DOI: 10.1371/journal.pmed.1002827.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingFemaleGene-Environment InteractionHealth BehaviorHealthy AgingHumansLife Change EventsMaleMiddle AgedPhenotypeRetirementConceptsCoronary artery diseaseArtery diseasePhenotypic agingUS older adultsSelf-reported circumstancesRetirement StudyLife course circumstancesAssociation of geneticMorbidity riskMultivariable associationsPotential policy targetsRetrospective natureAdulthood circumstancesPhenotypic AgeAdulthood adversityGenetic predispositionHealth behaviorsSocioenvironmental circumstancesUS populationOlder adultsPotential interventionsDisadvantaged subpopulationsGenetic riskGenetic scoreUS Health
2015
Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older
Arpawong TE, Lee J, Phillips DF, Crimmins EM, Levine ME, Prescott CA. Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. Behavior Genetics 2015, 46: 72-88. PMID: 26330209, PMCID: PMC4720538, DOI: 10.1007/s10519-015-9740-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesDepressionDepressive DisorderEthnicityFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansLife Change EventsMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalConceptsDepressive symptomsU.S. population-based studyRecent stressOlder adultsStress-diathesis hypothesisPopulation-based studySerotonin transporter gene promoter regionSingle nucleotide polymorphismsDepressive symptom levelsPopulation-based sampleAdults age 50Race/ethnicityAge 50Repeated-measures designSerotonin transporter polymorphismDepressive symptomatologySymptomsOlder individualsSymptom levelsReverse causationTransporter polymorphismMeasures studyDifferential effectsShort alleleStressful events