Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells
Parmigiani E, Ivanek R, Rolando C, Hafen K, Turchinovich G, Lehmann FM, Gerber A, Brkic S, Frank S, Meyer SC, Wakimoto H, Günel M, Louvi A, Mariani L, Finke D, Holländer G, Hutter G, Tussiwand R, Taylor V, Giachino C. Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells. Developmental Cell 2022, 57: 1847-1865.e9. PMID: 35803280, DOI: 10.1016/j.devcel.2022.06.006.Peer-Reviewed Original ResearchConceptsTumor-associated microglia/macrophagesGlioma cellsImmune surveillanceMicroglia/macrophagesImmune cell populationsBrain tumor cellsMouse glioma cellsCytokine expressionImmune attackImmune cellsMouse modelImmune evasionSuppression of NotchTumor cellsNotch inhibitionTumor initiationUpregulation of oncogenesNotch activityCell populationsGliomasCellsSurveillanceLow Notch activityNiche controlTherapy