2020
Chapter 6 Molecular genetics of meningiomas
Youngblood MW, Günel M. Chapter 6 Molecular genetics of meningiomas. Handbook Of Clinical Neurology 2020, 169: 101-119. PMID: 32553282, DOI: 10.1016/b978-0-12-804280-9.00006-8.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionGenomicsHumansMeningeal NeoplasmsMeningiomaMolecular BiologyMutationPrecision MedicineConceptsMolecular mechanismsNext-generation sequencing techniquesComprehensive genomic studiesRecent genomic findingsGenomic studiesPotential molecular therapyMolecular geneticsSequencing techniquesGenomic pathwayOncogenic pathwaysNumber eventsGenomic findingsDriver mutationsMutationsBasic science investigatorsPathwayMolecular therapyImportant insightsEmbryological originCommon brain tumorMolecular subgroupsGeneticsTumorigenesisMechanismProgression
2006
Molecular Genetic Analysis of Two Large Kindreds With Intracranial Aneurysms Demonstrates Linkage to 11q24-25 and 14q23-31
Ozturk AK, Nahed BV, Bydon M, Bilguvar K, Goksu E, Bademci G, Guclu B, Johnson MH, Amar A, Lifton RP, Gunel M. Molecular Genetic Analysis of Two Large Kindreds With Intracranial Aneurysms Demonstrates Linkage to 11q24-25 and 14q23-31. Stroke 2006, 37: 1021-1027. PMID: 16497978, DOI: 10.1161/01.str.0000206153.92675.b9.Peer-Reviewed Original ResearchConceptsGenome-wide linkage analysisMolecular genetic analysisGenetic analysisSusceptibility genesLinkage analysisSimple Mendelian traitPolymorphic microsatellite markersSignificant LOD scoreGenomic regionsMendelian traitsMicrosatellite markersCandidate lociGene chipOutlier approachOdds (LOD) scoreGenesChromosome 11q24Chromosome 11qAvailable family membersLOD scoreGenetic heterogeneityIa geneLociSib pairsGenetic factors