2023
Late Mortality After COVID-19 Infection Among US Veterans vs Risk-Matched Comparators
Iwashyna T, Seelye S, Berkowitz T, Pura J, Bohnert A, Bowling C, Boyko E, Hynes D, Ioannou G, Maciejewski M, O’Hare A, Viglianti E, Womer J, Prescott H, Smith V, Admon A, Akgun K, Anderson S, Aslan M, Au D, Backus L, Bajema K, Baraff A, Batten L, Berkowitz T, Bernstein T, Berry Wyatt K, Bogdan J, Bosworth H, Boucher N, Burwick N, Cabrales A, Cano J, Chai W, Chen J, Cheung K, Crothers K, Curtis J, Davis M, Del Monico E, Dobalian A, Doll J, Dominitz J, Eastment M, Fan V, Ferguson J, Floyd B, Fox A, Goetz M, Govier D, Green P, Hastings S, Hauschildt K, Hawkins E, Hebert P, Helfand M, Hickok A, Horowitz D, Hough C, Hu E, Ikuta K, Jones B, Jones M, Kamphuis L, Kaufman B, Knight S, Korpak A, Korpela P, Kumbier K, Langa K, Laundry R, Lavin S, Li Y, Linquist J, McCready H, Michel M, Miles A, Milne J, Monahan M, Morelli D, Mutalik P, Naylor J, Neiderhausen M, Newell S, Nugent S, Ong M, Osborne T, Peterson M, Peterson A, Rajeevan N, Reddy A, Rouse M, Rowneki M, Saha S, Saini S, Shah J, Shahoumian T, Shaukat A, Shepherd-Banigan M, Showalter W, Slatore C, Smith N, Smith B, Suri P, Sussman J, Takata Y, Teo A, Thomas E, Thomas L, Tuepker A, Veigulis Z, Vig E, Vranas K, Wang X, Wicks K, Winchell K, Wong E, Woods C, Wysham K, Yan L, Zulman D. Late Mortality After COVID-19 Infection Among US Veterans vs Risk-Matched Comparators. JAMA Internal Medicine 2023, 183: 1111-1119. PMID: 37603339, PMCID: PMC10442778, DOI: 10.1001/jamainternmed.2023.3587.Peer-Reviewed Original ResearchCOVID-19 infectionAdjusted hazard ratioRetrospective cohort studyUninfected comparatorsLate mortalityCohort studyHazard ratioMortality riskCOVID-19Acute COVID-19Excess mortality riskUnadjusted mortality ratesVeterans Affairs hospitalCOVID-19 persistHealth record dataCause mortalityCox regressionUS veteransExcess mortalityDay 180Mortality rateUninfected individualsPrimary analysisDay 91Excess deathsAnti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023
Yan L, Streja E, Li Y, Rajeevan N, Rowneki M, Berry K, Hynes D, Cunningham F, Huang G, Aslan M, Ioannou G, Bajema K. Anti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023. JAMA Network Open 2023, 6: e2331249. PMID: 37651140, PMCID: PMC10472184, DOI: 10.1001/jamanetworkopen.2023.31249.Peer-Reviewed Original ResearchConceptsCOVID-19 pharmacotherapyVeterans Health AdministrationVeterans Integrated Service NetworkSARS-CoV-2Higher Charlson Comorbidity Index scoresCharlson Comorbidity Index scoreNon-Hispanic veteransComorbidity Index scoreProportion of patientsSymptomatic COVID-19Multivariable logistic regressionCOVID-19 vaccinationCohort studyMedicare databaseVHA careUS veteransMAIN OUTCOMEMedical conditionsHispanic veteransPharmacotherapyHealth AdministrationIndex scoreCommunity careNonhospitalized personsWhite veterans
2022
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System
Bigdeli TB, Voloudakis G, Barr PB, Gorman BR, Genovese G, Peterson RE, Burstein DE, Velicu VI, Li Y, Gupta R, Mattheisen M, Tomasi S, Rajeevan N, Sayward F, Radhakrishnan K, Natarajan S, Malhotra AK, Shi Y, Zhao H, Kosten TR, Concato J, O’Leary T, Przygodzki R, Gleason T, Pyarajan S, Brophy M, Huang GD, Muralidhar S, Gaziano JM, Aslan M, Fanous AH, Harvey PD, Roussos P, Aslan M, Antonelli M, de Asis M, Bauer M, Brophy M, Concato J, Cunningham F, Freedman R, Gaziano M, Gleason T, Harvey P, Huang G, Kelsoe J, Kosten T, Lehner T, Lohr J, Marder S, Miller P, O Leary T, Patterson T, Peduzzi P, Przygodski R, Siever L, Sklar P, Strakowski S, Zhao H, Fanous A, Farwell W, Malhorta A, Mane S, Palacios P, Bigdeli T, Corsey M, Zaluda L, Johnson J, Sueiro M, Cavaliere D, Jeanpaul V, Maffucci A, Mancini L, Deen J, Muldoon G, Whitbourne S, Canive J, Adamson L, Calais L, Fuldauer G, Kushner R, Toney G, Lackey M, Mank A, Mahdavi N, Villarreal G, Muly E, Amin F, Dent M, Wold J, Fischer B, Elliott A, Felix C, Gill G, Parker P, Logan C, McAlpine J, DeLisi L, Reece S, Hammer M, Agbor-Tabie D, Goodson W, Aslam M, Grainger M, Richtand N, Rybalsky A, Al Jurdi R, Boeckman E, Natividad T, Smith D, Stewart M, Torres S, Zhao Z, Mayeda A, Green A, Hofstetter J, Ngombu S, Scott M, Strasburger A, Sumner J, Paschall G, Mucciarelli J, Owen R, Theus S, Tompkins D, Potkin S, Reist C, Novin M, Khalaghizadeh S, Douyon R, Kumar N, Martinez B, Sponheim S, Bender T, Lucas H, Lyon A, Marggraf M, Sorensen L, Surerus C, Sison C, Amato J, Johnson D, Pagan-Howard N, Adler L, Alerpin S, Leon T, Mattocks K, Araeva N, Sullivan J, Suppes T, Bratcher K, Drag L, Fischer E, Fujitani L, Gill S, Grimm D, Hoblyn J, Nguyen T, Nikolaev E, Shere L, Relova R, Vicencio A, Yip M, Hurford I, Acheampong S, Carfagno G, Haas G, Appelt C, Brown E, Chakraborty B, Kelly E, Klima G, Steinhauer S, Hurley R, Belle R, Eknoyan D, Johnson K, Lamotte J, Granholm E, Bradshaw K, Holden J, Jones R, Le T, Molina I, Peyton M, Ruiz I, Sally L, Tapp A, Devroy S, Jain V, Kilzieh N, Maus L, Miller K, Pope H, Wood A, Meyer E, Givens P, Hicks P, Justice S, McNair K, Pena J, Tharp D, Davis L, Ban M, Cheatum L, Darr P, Grayson W, Munford J, Whitfield B, Wilson E, Melnikoff S, Schwartz B, Tureson M, D Souza D, Forselius K, Ranganathan M, Rispoli L, Sather M, Colling C, Haakenson C, Kruegar D, Muralidhar S, Ramoni R, Breeling J, Chang K, O Donnell C, Tsao P, Moser J, Brewer J, Warren S, Argyres D, Stevens B, Humphries D, Do N, Shayan S, Nguyen X, Pyarajan S, Cho K, Hauser E, Sun Y, Wilson P, McArdle R, Dellitalia L, Harley J, Whittle J. Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System. JAMA Psychiatry 2022, 79: 1092-1101. PMID: 36103194, PMCID: PMC9475441, DOI: 10.1001/jamapsychiatry.2022.2742.Peer-Reviewed Original ResearchDiagnosis of schizophreniaPolygenic risk scoresBipolar disorderHealth care systemElectronic health recordsBilling codesRisk scoreUS Veterans Affairs Health Care SystemClinical InterviewVeterans Health Administration health care systemVeterans Affairs Health Care SystemDisorder-specific genetic factorsVeterans Health Administration electronic health recordsCare systemICD-9/10 codesMajor depression polygenic risk scoresSerious mental illnessEuropean ancestryDepression polygenic risk scoresPhysical health problemsAfrican ancestryUS veteransMajor depressionMillion Veteran ProgramMAIN OUTCOME
2020
Suicidal ideation, behavior, and mortality in male and female US veterans with severe mental illness
Aslan M, Radhakrishnan K, Rajeevan N, Sueiro M, Goulet JL, Li Y, Depp C, Concato J, Harvey PD. Suicidal ideation, behavior, and mortality in male and female US veterans with severe mental illness. Journal Of Affective Disorders 2020, 267: 144-152. PMID: 32063566, DOI: 10.1016/j.jad.2020.02.022.Peer-Reviewed Original ResearchConceptsSuicidal ideationCause mortalityBipolar disorderFemale veteransSuicide attemptsMore lifetime suicide attemptsMedical-psychiatric comorbidityLower overall mortalitySevere mental illnessPutative risk factorsLifetime suicidal ideationSelf-reported suicidal ideationLifetime suicide attemptsSuicide-specific mortalityClinical characteristicsOverall mortalityCox regressionPsychiatric comorbidityRisk factorsUS veteransCrude rateHigh riskSame diagnosisGeneral populationMale veterans
2018
Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder
Harvey PD, Posner K, Rajeevan N, Yershova KV, Aslan M, Concato J. Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder. Journal Of Psychiatric Research 2018, 102: 216-222. PMID: 29698922, DOI: 10.1016/j.jpsychires.2018.04.014.Peer-Reviewed Original ResearchConceptsSevere mental illnessSuicidal ideationPsychiatric comorbidityUS veteransHigh riskVeteran populationGreater clinical focusPopulation of patientsVeterans Affairs studyMultiple psychiatric comorbiditiesStudy of veteransLifetime suicidal ideationHigh suicide riskDemographic factorsBetter risk predictionMajority of veteransClinical factorsFunctional statusLifetime riskRisk factorsMajor depressionMultinomial logistic regressionLower riskSCZ patientsClinical attributes