2021
Polygenic Breast Cancer Risk for Women Veterans in the Million Veteran Program
Minnier J, Rajeevan N, Gao L, Park B, Pyarajan S, Spellman P, Haskell SG, Brandt CA, Luoh SW. Polygenic Breast Cancer Risk for Women Veterans in the Million Veteran Program. JCO Precision Oncology 2021, 5: 1178-1191. PMID: 34381935, PMCID: PMC8345920, DOI: 10.1200/po.20.00541.Peer-Reviewed Original ResearchConceptsBreast Cancer Risk Assessment ToolCancer Risk Assessment ToolIncident breast cancerAbsolute lifetime riskAA womenRisk assessment toolIncident casesLifetime riskBreast cancerMillion Veteran ProgramAccurate breast cancer risk assessmentProstate Cancer Cohort ConsortiumBreast cancer risk assessmentPrior BC diagnosisBreast cancer riskClinical risk modelVeteran ProgramRisk prediction modelCancer risk assessmentAssessment toolIncident BCAfrican ancestryHazard ratioProspective cohortMultiracial cohort
2019
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nature Neuroscience 2019, 22: 1394-1401. PMID: 31358989, PMCID: PMC6953633, DOI: 10.1038/s41593-019-0447-7.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesHigh linkage disequilibrium regionLinkage disequilibrium regionWide association studyDisequilibrium regionBioinformatics analysisTranscriptomic profilesMillion Veteran ProgramChromosome 17Genetic risk factorsNew insightsUK Biobank dataReexperiencing of traumaStriatal medium spiny neuronsVeteran ProgramSignificant regionsCAMKVEuropean AmericansBiobank dataMedium spiny neuronsTCF4BiologyKANSL1African American cohort