2024
Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy
Wang Y, Zhang M, Wang R, Lin J, Ma Q, Guo H, Huang H, Liang Z, Cao Y, Zhang X, Lu Y, Liu J, Xiao F, Yan H, Dimitrova N, Huang Z, Mably J, Pu W, Wang D. Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy. Circulation Research 2024, 135: 434-449. PMID: 38864216, PMCID: PMC11257812, DOI: 10.1161/circresaha.123.323356.Peer-Reviewed Original ResearchCardiac hypertrophyHeart failureGenome-wide transcriptome analysisCardiac functionDeterioration of cardiac functionResponse to pressure overloadAssociated heart failureTherapeutic potentialLoss-of-function miceDilated cardiomyopathy patientsPressure-overload conditionsInhibit cardiac hypertrophyTranscriptome analysisCardiac-specific knockoutMaladaptive cardiac remodelingLong noncoding RNAsVentricular wall thickeningNoncoding RNAsTranscriptional network analysisCardiomyopathy patientsMarker elevationPressure overloadCardiac remodelingPathological hypertrophyAdverse remodeling
2018
Chapter 16 Genetic Variations of Long Noncoding RNAs in Cancer
Dimitrova N. Chapter 16 Genetic Variations of Long Noncoding RNAs in Cancer. 2018, 289-308. DOI: 10.1016/b978-0-12-811022-5.00016-4.Peer-Reviewed Original ResearchComprehensive genome analysisFunction of lncRNAsLong noncoding RNALncRNA lociCancer susceptibility variantsGenome analysisGenetic variationRegulatory regionsNoncoding RNAsGenomic dataSomatic variationExpression patternsFocal amplificationCancer predispositionPhysiological roleLncRNAsFunctional consequencesHuman cancersNucleotide polymorphismsExpression levelsRNAMechanism of actionNovel classIntriguing associationStrong linkage