2024
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
Ferrer J, Dimitrova N. Transcription regulation by long non-coding RNAs: mechanisms and disease relevance. Nature Reviews Molecular Cell Biology 2024, 25: 396-415. PMID: 38242953, PMCID: PMC11045326, DOI: 10.1038/s41580-023-00694-9.Peer-Reviewed Original ResearchCis-regulatory functionLong non-coding RNAsGene transcriptionNon-coding RNAsTranscription factorsControl of gene transcriptionProtein-coding transcriptsActivation of gene transcriptionDosage-sensitive genesEncode transcription factorsX-chromosome inactivationTranscription unitTranscription elongationGenetic experimentsTranscriptional regulationTranscript stabilityCharacterized lncRNATranscriptionHuman diseasesFindings of lncRNAsImprinted lncRNAsLncRNA involvementLincRNA-p21Severe phenotypeLncRNAs
2020
p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis
Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Molecular Cell 2020, 77: 761-774.e8. PMID: 31973890, PMCID: PMC7184554, DOI: 10.1016/j.molcel.2019.12.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinogenesisCell LineCell ProliferationCells, CulturedChromatinEnhancer Elements, GeneticGene Expression RegulationHumansLung NeoplasmsMiceMice, Inbred C57BLPromoter Regions, GeneticProto-Oncogene MasProto-Oncogene Proteins c-mycRNA, Long NoncodingStress, PhysiologicalTumor Suppressor Protein p53ConceptsMYC transcriptional networkLong noncoding RNA PVT1Cellular proliferationTumor suppressor p53Chromatin organizationTranscriptional networksTarget genesMYC transcriptionTranscriptional activityKb downstreamMYC levelsOncogenic signalingSuppressor p53Suppress tumorigenesisDNA damageRNA PVT1Autochthonous mouse modelMYCTranscriptionP53Anti-proliferative activityTumor progressionTumor growthLung cancerMouse model